Sentences with phrase «control cell development»

Not exact matches

It is the central problem of development where collections of cells control the growth or genetic expression of individual cells.

The observation that loss - of - function mutations in DENND5A causes epileptic encephalopathy suggests that DENND5A protein controls membrane trafficking pathways critical for normal neuronal development and strengthens the argument that protein trafficking processes in cells are critical for normal neuronal development and function.

Cells have more than one trick up their sleeve for controlling certain genes that regulate fetal growth and development.

The brainlike structures created from cells taken from autistic children showed increased activity in genes that control brain - cell growth and development.

Several pint - size projects are in development, including gene chips, protein arrays, stem cell controls and electronic circuits.

The gene makes a protein that controls the quantities of other proteins a cell produces, and studies in roundworms suggest that the gene is involved in growth and development throughout life.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

Duke University biologist Pelin Volkan and colleagues have identified a set of genetic control switches that interact early in a fly's development to generate dozens of types of olfactory neurons, specialized nerve cells for smell.

These play a key role in controlling gene expression and, thereby help regulate the cell's development, growth and function.

Auxin controls a range of responses in plants, including cell and tissue growth and normal development.

Somehow, scientists know, the genes that control development — generally turned off in adult cells — get turned back on again by the oocyte, enabling the cell to take on the youthful potential of a newly fertilized egg.

«Regulator of chromosome structure crucial to healthy brain function and nerve development: Cohesin protein identified as key to control of chromosome structure underlying nerve cell network formation.»

The researchers» discovery of a control switch that acts on the UPR pathway, published March 25 in the online edition of EMBO Reports, opens new drug development avenues for treating a wide variety of diseases by modulating the UPR pathway to prevent excessive cell death.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

The study, «VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer» found that novel non-coding parts of the human genome known as vlincRNAs (very long intergenic, non-coding RNAs) triggered by ancient viruses, participate in the biology of stem cells, and in the development of cancer.

«The nematode has been able to employ a breakdown product of its own metabolism as a plant hormone to control the development of plant cells,» said lead author and research group leader Dr Shahid Siddique.

Cells that make AP2 - G enter sexual development, something that the groups are now able to control experimentally.

Fresh insights into how our cells control muscle development could aid understanding of muscular dystrophy and other inherited diseases.

«TGF - beta functions as an important time signal that controls when a stem cell should stop producing one type of nerve cell and instead start producing another, while also gradually limiting the stem cell's future development capacity,» says Johan Ericson, Professor of Developmental Biology, who led the study.

There is no question that ability to generate glucose - responsive, human beta cells through controlled differentiation of stem cells will accelerate the development of new therapeutics.

In this study, using a mouse transgenic approach, the scientists demonstrated that ILC2s express a checkpoint molecule, known as «PD - L1», that functions to control the expansion of allergy - inducing Th2 cells and the development of allergic pulmonary and gut tissue inflammation.

Inserting circuits of synthetic DNA into cells means we can control their development — and could allow us to create enhanced organs

«Molecular time signalling controls stem cells during brain's development.»

To understand the development of the human brain, the researchers looked to a much simpler animal, the fruit fly, in which they could control and observe cells more easily.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

Although the importance of stem cells in fuelling plant growth and development still many questions on their tight molecular control remain unanswered.

«Three rings stop cell division in plants: Development of a triarylmethane compound for possible control of plant growth.»

This pathway, the investigators report in Nature Medicine, is very similar to apoptosis (the controlled cell death program thought to exist only in multicellular organisms), but with subtle differences suggesting that it could be specifically targeted for anti-parasitic or - microbial drug development.

Epigenetic controls are molecular switches that turn genes on or off to orchestrate a cell's development from a generic cell to a specialized cell like a neuron.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

«The development of these cells is probably something we want to encourage since these cells control inflammation on the inner surface of the intestines,» Cervantes - Barragan said.

Wnt signals play a key role in directing stem cells during embryonic development, which led Geiger and colleagues to hypothesize that it might be helping to control stem cell growth and pluripotency in the gut later in life.

Ueda's group also discovered HOMEODOMAIN GLABROUS11 (HDG11) and HDG12, the factors derived from the egg cells, which are responsible for controlling the asymmetric division of the zygote and development of the embryo.

And this molecular switch controls how cells behave and interact with their neighbors during embryonic development.

They have generated excitement over the past few decades because scientists can study them in the laboratory to discover the genetic switches that control the development of specialized tissues in the embryo and fetus, and also because of their potential to replace body tissues that have broken down, such as pancreatic cells in those with diabetes or heart muscle cells in those with congestive heart failure.

This cell death bore the hallmarks of apoptosis, a controlled cell suicide that is needed for the normal development of an embryo, and to ensure that our immune system contains the correct array of cells.

This could be because the brains of mammals lack the pre cursor cells or the growth factors that control and support the development of projection neurons.

Thus, in discovering that NK cells control ATMS and consequently inflammation, the Joslin scientists have identified a new mechanism in the development of obesity - induced insulin resistance in mouse models.

He is co-director of the Jonsson Comprehensive Cancer Center Cell Biology Program Area and co-director for the UCLA Center for Cell Control, a NIH Roadmap Initiative Nanomedicine Development Center.

As described in the journal Genes & Development, the researchers identified a new pathway controlling heterochromatin organisation in mouse embryonic stem cells.

One is straightforward — during development, cells are assuming their identities and need precise control over protein production, so cells lacking a gene expression regulation mechanism are bound to have defects, particularly in the case of specialized cells like neurons.

For a long time it has been known that the protein TOR — Target of Rapamycin — controls cell growth and is involved in the development of diseases such as cancer and diabetes.

More importantly, Zhang and his team for the first time found that treating the pancreatic tumor cells with MIR506 induced autophagy, a process that occurs as a normal and controlled part of an organism's growth or development and that could promote cancer cell death.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

We focus more specifically on: (A) GMP translations of CTP production and Quality Control assay development to evaluate such production (in collaboration with Roslin Cells, UK).

With respect to technology development, the group is leveraging recent advances in nanotechnology and chemical biology to establish a host of core, cross-disciplinary platforms that will collectively enable them to extensively profile and precisely control cells and their interactions within the context of complex systems.

The development of extraordinary new technologies for genome editing, optogenetics (the use of light to control living cells) and the rapid creation of peptides (small chains of amino acids) for therapeutic compounds are just a few examples of the cutting edge research being conducted by the 2017 National Finalists in Life Sciences.

Of note today: non-exclusive breastfeeding increases the risk of HIV transmission via the alteration of gut microbiome / T - cell activation; Fasting altered the gut microbiome in beneficial ways but only in mice previously fed a high fat diet; An investigation into new species of the honey and bumblebee gut commensal genus Gilliamella; Catfish development shapes gut microbial community structure independent of diet; A metagenomic analysis of the skin microbiome of the frog, Craugastor fitzingeri; The microbiome is altered during the bioremediation of herbicide contaminated soil; The impact of urban density on the soil microbiome; A randomized placebo controlled clinical trial of a microbiota based drug for the prevention of Clostridium difficile Infection; and the virome of the Cuatro Ciénegas Basin of Mexico

Clearance of senescent cells has been advocated as a part of the SENS vision for the medical control of aging for more than a decade now, and it is very encouraging to see the research and development community at last coming round to this view and making tangible progress.

Fine tuning of IRF - 4 expression by SWAP - 70 controls the initiation of plasma cell development.