Sentences with phrase «control cell growth»

Hereditary cancer syndromes are caused by variants in genes that control cell growth in multiple tissue types.

The test measures the activity of genes that control cell growth, and others that indicate a likely response to hormone therapy treatment.

Tumor suppressor genes generally suppress tumor growth and control cell growth.

But sometimes the genes that control cell growth go out of whack, enabling cells to multiply out of control.

Again, prostaglandins are important because they appear to promote cancer by activating pathways that control cell growth and movement.

A truly multidisciplinary subject, tissue engineering requires the skills of chemists and materials engineers to design and build organ scaffolds, physicists and mathematicians to model tissue growth, and biologists to monitor and control cell growth.

The NCI defines recurrence as cancer that returns after a patient has had no signs of out - of - control cell growth for at least a year.

The problem is that when RAS genes get mutated, that switch just won't turn off, and that leads to out of control cell growth.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

CELLS GONE WILD Turning off the gene Apc in mouse intestinal cells in a culture dish spurs out - of - control cell growth (left panel, pink).

Baylin says certain genes that control cell growth get turned down periodically during certain stages of life, including embryogenesis, when organisms are growing and developing rapidly.

The most common mutations, occurring in five of the women, occurred in genes including ARID1A, PIK3CA, KRAS and PPP2R1A, all known for controlling cell growth, cell invasion and DNA damage repair.

Investigators focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.

Nicknamed the «guardian of the genome,» p53 controls cell growth and cell death.

The polarity site (yellow traces) is a sensor, processor and motor all in one — a multifunctional instrument that controls cell growth and movement.

For a long time it has been known that the protein TOR — Target of Rapamycin — controls cell growth and is involved in the development of diseases such as cancer and diabetes.

In tumour cells, the signals controlling cell growth and survival are dysfunctional, thus enabling the cells to grow in an uncontrolled manner.

It controls cell growth, the speed of your metabolism and how sensitive your body is to other hormones.

HGH, also called as Human Growth Hormone, is responsible in controlling cell growth and reproduction of humans.

Not exact matches

It is the central problem of development where collections of cells control the growth or genetic expression of individual cells.

Cells have more than one trick up their sleeve for controlling certain genes that regulate fetal growth and development.

New cell growth is stimulated as oil is brought under control and fine lines and wrinkles are smoothed away.

The brainlike structures created from cells taken from autistic children showed increased activity in genes that control brain - cell growth and development.

A protein called YAP1 was previously shown to contribute to the growth of lung cancer cells; however, it was unknown how YAP1 controls lung cancer growth and progression.

As might be expected of an autoimmune disease, where the immune system turns on healthy tissue, all the genes play a role in controlling the growth and multiplication of cells in the immune system.

The gene makes a protein that controls the quantities of other proteins a cell produces, and studies in roundworms suggest that the gene is involved in growth and development throughout life.

Vidaza, from Pharmion, was approved for myelodysplastic syndromes, a bone marrow disorder marked by rapidly dividing immature blood cells that no longer respond to growth - control mechanisms.

If we can boost the immune system and allow microglia to do their job and control brain tumor stem cells, it would be like removing the seed from the soil — stopping the tumor growth before it starts to get out of control.»

Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.

But the researchers also found that the new molecule intervened directly in the growth of the cancer itself, inhibiting a protein that controls the division and proliferation of malignant cells.

«Knee joint signals bones to grow: Researchers suggest neighboring cells in nearby joints help control bone growth in mice.»

They found numerous genes activated in the XYL regulon - controlled yeast that upregulated pathways involved in growth, such as cell wall maintenance, cell division, mitochondrial biogenesis and adenosine triphosphate (ATP) production.

«A general message from these studies is that cancer cells benefit from modulating epigenetic factors like SIRT6 by acquiring the ability to override normal cellular growth control patterns,» says Mostoslavsky, an associate professor of Medicine at Harvard Medical School and an associate member at the Broad Institute.

«In most cases we think the body's growth control mechanisms eventually stop the cells from proliferating further, but in occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the work.

By providing a woman's family history of these cancers, including the ages they were diagnosed, the programs calculate a probability that the patient carries a harmful mutation in BRCA1 or BRCA2 (genes involved in controlling malignant cell growth).

The tumors» recruitment of these inflammatory cells thus enabled them to resist what would otherwise have been a deadly dose of radiation, so that their growth slowed only modestly compared to control mice that had received no radiation.

Writing in the journal eLife, the authors suggest that bone growth is controlled not only from within the bone itself, but by neighboring cells situated in nearby joints.

These play a key role in controlling gene expression and, thereby help regulate the cell's development, growth and function.

In contrast, viruses that cause cancer, such as the human papillomavirus that is responsible for most cases of cervical cancer, disrupt a cell's genome, thereby triggering out - of - control growth.

Auxin controls a range of responses in plants, including cell and tissue growth and normal development.

The runaway replication of cancer cells can also traced to genetic causes — mutations that remove the normal controls on cell growth.

A drug approved by the Food and Drug Administration (FDA) for melanoma in combination with a common cholesterol - lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

In summary, JAK / STAT controls the three main cell signals responsible for the specification and growth of limbs, both in vertebrates and invertebrates.

«These cells will be a key tool for finding ways to stimulate and control human bone growth for regenerative medicine or bone repair,» Hsiao said.

It spurred the fastest growth of fibroblast cells, with 17 per cent more cells formed after six days as in a control culture.

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasis Lab.

Star - shaped brain cells called astrocytes, usually dismissed as support cells for the attention - grabbing neurons, now seem to control the growth of new neurons in adult brains.

Abnormal and uncontrolled production of this class of proteins, known as transcription factors, allow for cells to bypass growth control mechanisms and to develop characteristics necessary for invading surrounding tissues.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.