Sentences with phrase «control cellular function»

«Our work suggests that the apparent complexity of protein networks is deceiving, and that a circuit involving a small number of proteins might control each cellular function,» said senior author Shohei Koide, PhD, professor of biochemistry & molecular biophysics at the University of Chicago.

This is the first time scientists have combined heat and nanomagnetic particles to control cellular function, and the new technique, published online June 27 in Nature Nanotechnology, offers certain advantages over earlier and alternative methods of ion - channel manipulation.

Not exact matches

Some autopsy data shows that infants of smokers have signs of established hypoxic - ischemic cellular injury in the brain and the heart which probably occurred in antenatal life, may have been caused by suboptimal placental function and may have been sub-clinical, but if the baby continues to be in a vulnerable environment exposed to post-natal passive smoking, this could affect autonomic nervous system function and lead to poor temperature control, and poor heart rate and respiration control.

However, the researchers found that a well - known cellular mechanism — one that controls how proteins acquire new functions — also plays a major role.

Optogenetic methods and tools have evolved fast, and in addition to be able to control cellular activity, researchers can now control the activity of gene function.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

These functions range from metabolism, maintenance and control of the cellular structure to the exchange of signals with other cells and the environment.

A unique feature of this DREADD system not found in other methods is that it is not limited to the control of neurons — activity levels of certain enzymes in almost every tissue type can be controlled to probe mechanisms of basic cellular function.

A third class transfers the SNOs to additional proteins that control numerous additional cellular functions, including growth, movement and metabolism, and also protect cells from injury.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

«Now that we have the cellular and molecular information, the future promises to be very exciting when this knowledge can be used to understand how this system is formed during gestation and how the different neuron types go about controlling the body's functions,» says study leader Patrik Ernfors, professor of tissue biology

These studies will provide new leads to understand the cellular pathways that control K2P function in other organisms.

Studying coral calcification with antagonists can provide further information and knowledge to better understand the role and function of genes that participate in the cellular control mechanism, and in the coral organic matrix.

Thus, size constraints suggest that distinct regions of the axon behave as de facto isolated subcellular compartments, and that neurons have evolved strategies to ensure tight spatial and temporal control of critical cellular functions.

The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.

Their crisscrossing paths and collective efforts have nonetheless led to a clear - eyed understanding of how neurons — the brain's cellular building blocks — form and function and how ion - conducting channels control the flow of electrical signals through the nervous system.

Post-transcriptional control processes regulate the rate and timing of protein production and are of central importance to proper cellular function.

Sirtuins are enzymes regulating the expression of genes that control the function of cells through key cellular signalling pathways.

Posttranscriptional control processes regulate the rate and timing of protein production and are of central importance to proper cellular function.

March 13, 2017 Parallel cellular pathways activate the process that controls organ growth A new study from the University of Chicago suggests that while proteins that control organ growth accumulate around the edges of cells, they actually function at a different cellular site.

That's because hormones are powerful messengers that direct and control every function in the body and influence cellular activity.

In youth, autophagy — controlled self - destruction, literally «self - eating» — removes and recycles cellular waste that would otherwise compromise cellular function and regeneration of replacement structures.

To accurately assess thyroid function, it must be understood that deiodinase enzymes are essential control points of cellular thyroid activity that determine intracellular activation and deactivation of thyroid hormones.

When incorporated into the cell membranes of the body, these omega - 3 and omega - 6 fatty acids function as precursors for eicosanoids that control a host of cellular functions and responses.

During these times we rely on the liver glycogen to keep our blood sugar from falling too low and to prevent a hypoglycemic state which is essential to support cellular metabolism, thyroid function, regulate blood sugar and keep your stress hormones under control.

While other electrolytes like Potassium, Calcium, Magnesium, etc. are all important components for cellular function and health, sodium is the principle electrolyte controlling blood volume particularly during exercise, thus maintaining adequate blood volume is crucial for both performance and health.

• Help regulate oxygen uses and energy production • Important in nerve, muscle and cellular functions • Play a vital role in cognitive function, including memory and mood • Involved in regulation of metabolism, body temperature, blood sugar and insulin control, thyroid function, carbohydrate metabolism and control over hormonal processes • Lubricate joints and improve mineralization of bones • Help transport cholesterol • Improve digestion of the gut • Build the immune system and regulate inflammatory response • Can help direct the processes that stimulate fat breakdown and utilization • Helps regulate blood pressure

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«The genotoxicity of mainstream smoke carcinogens manifests as mutations occurring in key cancer - related genes, i.e., proto - oncogenes or tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung tumors of active smokers.»