Sentences with phrase «control embryonic»
To achieve this result, the researchers studied the interactions between some molecules that control embryonic development.
https://www.sciencedaily.com/ Not exact matches
Look to birth control, gay marriage, abortion, and embryonic stem cell research if you need examples.
(i) a woman's right to an abortion; (iii) medical immunization of teen girls (and boys) against HPV; (iv) assisted suicide; (vi) gay marriage; (vii) my right to view art and theatre deemed «offensive,» «blasphemous» or «obscene» Catholics; (viii) basic $ ex education for older school children; (ix) treating drug abuse as principally a medical issue; (x) population control; (xi) buying alcohol on a Sunday in many places; (xii) use of condoms and other contraceptives; (xiii) embryonic stem cell research; (xiv) little 10 year - old boys joining organizations such as the Boy Scouts of America, regardless of the religious views of their parents; and (xv) gays being allowed to serve openly in the military.
MTHFR + / + or + / - pregnant mice on a control diet or folic acid - supplemented diet (20-fold higher than the recommended intake) were examined for embryonic loss, delay, and defects.
They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).
There have also been safety concerns confronting all hESC studies, including worries that the embryonic stem cells could proliferate out of control.
They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.
Lacin and Truman believe the insights from their study will now make it possible to investigate how molecular events, which occur from embryonic to adult stages, control the formation and function of the nervous system in fruit flies, with possible translation to humans.
«Genomic «dark matter» of embryonic lungs controls proper development of airways.»
This study provides experimental evidence which shows the important role of RNA levels in the controlling the fate of embryonic stem cells, and shows an understanding of RNA's ability to differentiate stem cells at the molecular level.
«In the longer term, we'd like to produce controlled heterogeneous embryonic bodies,» concludes Wei Sun.
Working with mouse embryonic stem cells (mESCs), scientists at the IBS Center for RNA Research have come one step closer to understand how to control induced pluripotent stem cells.
Sox2 control region - deleted cells have lost the typical appearance of embryonic stem cells (C) and do not express Sox2 (D).
Wnt signals play a key role in directing stem cells during embryonic development, which led Geiger and colleagues to hypothesize that it might be helping to control stem cell growth and pluripotency in the gut later in life.
And this molecular switch controls how cells behave and interact with their neighbors during embryonic development.
Early embryonic development of vertebrates is controlled by the genes and their «grammar.»
The Center for RNA Research at the Institute for Basic Science has succeeded in revealing, for the first time, the mechanism of how miRNAs, which control gene expression, are regulated in the early embryonic stage.
In previous experiments, Isacson and his colleagues had found that undifferentiated embryonic stem cells, when injected into animals, seemed eager to become neurons; the problem was they frequently grew out of control and formed tumorous growths.
Very soon after fertilization, the control of embryonic development shifts from pre-existing maternal gene products to the products of genes encoded by the early embryo (or zygote).
As described in the journal Genes & Development, the researchers identified a new pathway controlling heterochromatin organisation in mouse embryonic stem cells.
In addition, this is not the only case in which the regulatory circuits that control early embryonic development in humans show greater similarity to those employed in bovine embryos than to those that operate in the mouse system.
The goal of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine embryonic stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse line ② or from genetically modified mouse embryos with two aims:
This meant analysing pure embryonic stem cells to determine which genes are turned on or off, and how the genes are controlled.
Researchers investigating signaling pathways which control pluripotency highlight newly found interactions and redundancies in mouse embryonic stem cells
They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.
Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.
We are the home of the UK Stem Cell Bank which provides a world - leading resource of ethically - sourced, quality - controlled human embryonic and other stem cell lines for research applications.
Newly evolved genes can rapidly assume control over fundamental functions during early embryonic development, report scientists from the University of Chicago.
«Basically, this study shows that the genetic makeup of individual human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.
«Human Embryonic Stem Cell Lines Differ In Genes That Could Control Disease Susceptibility.»
Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal
The research team hypothesized that HARs instead acted as «enhancers,» controlling when and for how long certain genes were switched on during embryonic development.
Integrating this new information into computational models, my colleagues and I predicted that about 5 percent of HARs function as noncoding RNAs, while most are enhancers that control gene expression during embryonic development.9
By combining the use of magnetic tweezers with in vivo laser ablation, we locally control physiologically relevant deformations in wild - type Drosophila embryonic tissues.
The positioning of the cells controls their genetic program and their differentiation into embryonic or extra-embryonic tissues.
Human embryonic stem cells grown at the University of Wisconsin - Madison randomly changed into cell types found in the A) gut B) brain C) bone marrow D) cartilage E) muscle F) kidney Scientists haven't learned to control the development.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
The safety and efficacy of using embryonic and other stem cells for tissue regeneration will depend on harnessing and precisely controlling their proliferative capacity.
Wnt / b - catenin / Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4 / Arf locus.
Scientists are convinced that insulin - producing cells from embryonic pigs will eventually be transplanted into humans as one approach to controlling what has become a worldwide spike in diabetes.
The use of embryonic stem cells as therapeutics requires firm understanding of the mechanisms that control their proliferation and differentiation.
It has also been reported that Kap1 controls endogenous retroelements during early embryonic development and in embryonic stem cells but not in adult fibroblasts [45].
The study could provide clues to the genetic code that controls the expression of genes, and may also further our understanding of embryonic development and diseases such as cancer.
May 07, 2015 Genetic changes to basic developmental processes evolve more frequently than thought Newly evolved genes can rapidly assume control over fundamental functions during early embryonic development, report scientists from the University of Chicago.
And on the software side, currently embryonic HTML5 capabilities will be mainstream, which means that a «website» can do everything an ePub book does today — work offline, have slick touch controls, resizable fonts, whatever — plus a lot more.