Sentences with phrase «control gene activity»

The researchers found that the ability to control gene activity allows Ikaros to act as a master regulator of the function of blood cells.

Methylations are chemical changes that control gene activity, that is, whether they are active or not.

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

The scientists found that, in general, the systems that are used to control gene activity have many similarities in mice and humans, and have been conserved, or continued, through evolutionary time.

Transcription factors are proteins that help control gene activity, usually turning it up a notch or two.

For more than a decade, the husband - and - wife team has been investigating how a large protein complex called SAGA, which helps control gene activity in organisms from yeast to humans, influences developmental processes.

Scientists have known for years that the genome is riddled with sequences that control gene activity and is not just made up of genes.

Just as engineers rearrange capacitors and resistors to create different electric circuits, researchers can arrange gene promoters and repressors — stretches of DNA that control gene activity — to create gene circuits with different properties.

Compared with living people, Neandertals and ancient Siberians known as Denisovans had slightly different patterns of DNA methylation — a chemical modification of DNA that doesn't change the information in genes but helps control gene activity.

The finding could reveal much about how cells control gene activity, and also illuminate cancer, multiple sclerosis, and other diseases spurred by faulty gene expression.

Now, Shannon Xu, together with Gantz and Bier, employ CRISPR / Cas9 to edit gene regulatory elements in their native genomic environments, revealing new fundamental mechanisms that control gene activity, as described Feb. 6 in eLife.

The switches that control gene activity are located here.

Far from being junk, it's where molecular switches that help control gene activity are located.

«The elephant results revealed noncoding sequences in the human genome that we predict may control gene activity and reduce the formation of mutations and cancer.»

They discovered that genetic variation influencing a person's risk for multiple sclerosis, rheumatoid arthritis, and type 1diabetes is more likely to control gene activity in T cells than in monocytes.

The new method may make some types of gene therapy easier and could be a boon for researchers hoping to control gene activity in animals, scientists say.

For my dissertation, I studied the fundamental mechanisms that control gene activity in plants.

The project uncovered 4 million spots in our DNA that act as switches controlling gene activity.

Though this study doesn't yet identify the mechanism that controls gene activity for generations after a famine, the findings build a foundation to do so, Baugh said.

In a pioneering study, he applied these tools to a genome - wide study of disease - related changes in the epigenome — the layer atop the genome that controls gene activity and is altered by the environment — of immune cells isolated from patients with asthma.

Not exact matches

They asked the question, What controls the activity of a single gene, turning it on or off?

But it is not actually the crucial question, which is, What controls the activity of the complex interacting set of genes, which produces a nerve cell or a muscle cell?

What all these have in common is that, without any central control, individual units (genes, cells neurons or workers) respond to simple, local information, in ways that allow the whole system (cells, brains, organisms or colonies) to function: the appropriate number of units performs each activity at the appropriate time.

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence.

The brainlike structures created from cells taken from autistic children showed increased activity in genes that control brain - cell growth and development.

Every genome contains many thousands of short bits of DNA called «enhancers,» whose role is to control the activity of genes.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

This bundling of DNA acts as a switchboard for controlling genes» activity and directs a cell's complex molecular machinery.

Other techniques exist for remotely controlling the activity of cells or the expression of genes in living animals.

Many of the additional 38 missing genes looked like they coded for proteins involved in controlling the activity of other genes.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

Within the duplicate regions, Carmona - Mora and her colleagues discovered many switches, known as enhancers, important for controlling activity of genes.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

Significantly, treatment with 6AN specifically decreased the activity of genes with malignant, cancer - spreading functions, like cell cycle control and DNA repair.

«Previous techniques that have been used to investigate DNA control sequences usually rely on sorting cells one by one and measuring gene activity in each of them,» says Dr Eva Yus, lead author of the paper.

Publishing their findings in the open - access journal Nature Communications, the researchers discovered DNA sequences for «control dials» that consistently produce very high levels of gene activity.

Optogenetic methods and tools have evolved fast, and in addition to be able to control cellular activity, researchers can now control the activity of gene function.

But as you said, as an individual eats a high - fat diet or is exposed to other types of environmental exposures, the ability of the liver to adapt involves turning on and turning off certain liver genes to control the liver's activity, and that's mediated through these epigenetic mechanisms that modify the activity of established liver genes.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

When these birds sing, the activity of a master gene called FoxP2 declines in a key region of the brain involved in vocal control known as Area X.

Nestler: It's, to a first level of approximation, it's simple and straightforward, that there are a set number of modifications that could be made to the DNA itself or to the proteins that bind to DNA and control its structure, and activity and that those small number of modifications either turn a gene on or off.

The pair of studies bring renewed focus to the epigenetics of T cells — the multilayered system of molecular switches, accelerators, and throttles that controls the activity of genes.

Scientists of the Transfaculty Research Platform «Molecular and Cognitive Neurosciences» (MCN) at the University of Basel and the Psychiatric University Clinics have now described a network of genes that controls fundamental properties of neurons and is related to working memory, brain activity and schizophrenia.

Basel scientists have now identified a network of genes that controls fundamental properties of neurons and is important for human brain activity, memory and the development of schizophrenia.

These Hox genes control the activity of a multitude of other genes that are responsible for the early development of an organism.

More analysis showed that altering Cdk5 activity changed the level of several groups of genes that were also affected by aging, including those that control immunity, energy, and antioxidant activity.

This result reflected earlier findings that ILC and T cell subclasses produce similar sets of cytokines, but also revealed differences in how the two cell types control the activities of these key immune response genes.

Many researchers think that it participates in controlling the activities of genes and in helping the 1 metre of DNA present in each cell to twist and pack itself into the cell's minute nucleus.

Blau's group found that the daily changes in Rho1 activity are controlled by rhythms in transcription of a gene very similar to human Puratrophin - 1.

Much media attention has focused on a company's ability to control all activities related to a patented gene.