Sentences with phrase «control gene transcription»

Not exact matches

The pilot project tested a dozen or so of the most commonly used gene promoters (regions of DNA that facilitate gene transcription) and segments of DNA that encode ribosome - binding sites (sequences of messenger RNA that control protein translation) to determine whether they behave consistently in different cellular contexts.

Aiolos is a member of a class of proteins called transcription factors — proteins that control which genes are turned on or off by binding to DNA and other proteins.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

Other proteins, called transcription factors, interact with the genes more directly: They bind to landing sites situated near the gene under their control.

Using an innovative crystallization technique for studying three - dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the «magic spot» — a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

Furthermore, they found that the Sp7 transcription factor directly controlled gene expression of the Fgf ligands.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

Based on previous work, the researchers had reason to think it was controlled by transcription factors — proteins that control the expression of certain genes by binding to DNA at specific locations to induce (or block) the transcription of information from DNA to RNA.

All of these genes code for transcription factors, which are proteins that control the expression of other genes.

Using the recently completed tomato genome sequence they then identified the gene as SlGLK2 — a so - called transcription factor, which controls when and where other genes are switched on or off.

Jones, 62, is an expert in transcription elongation, a process that controls the expression of HIV and cancer genes; she has been at the Salk since 1986.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

Blau's group found that the daily changes in Rho1 activity are controlled by rhythms in transcription of a gene very similar to human Puratrophin - 1.

These include proteins which control important processes in the cells, for example the transcription factors which activate genes for the production of new proteins.

The proteins in turn are the workhorses of biology, spurring chemical reactions inside cells and controlling the expression, transcription, and replication of the genes themselves.

The resulting papers published in Nature all tell similar stories of shared evolution between species — for instance, the commonalities of regulatory networks of genes and the transcription factors that control their activation.

Previous research found that Short - root activates other transcription factors as well, creating a cascade in which each gene - regulating protein controls the next in the root development pathway.

Transcription factors are proteins that help control gene activity, usually turning it up a notch or two.

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

In early work in Sweden, Jansson and his team investigated how distribution of sugars in plants could be controlled by a special protein called a transcription factor, which binds to certain genes and turns them on or off.

An analysis of all gene transcription in the cultured cell lines turned up a large gene complex in which gene expression differed conspicuously in cells from patients compared to controls.

While my husband was on call, and even when he wasn't, I buried myself in transcription factors that control developmental genes.

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

Since many of the genes containing «fragile» nucleosomes are controlled in a continuous manner by nutrient availability, modulation of promoter nucleosome stability may be a strategy used to coordinate growth - related transcription on a genome - wide level.

Transcription factors are expressed (or made) at different levels in different cell types, and control what genes are expressed in every cell, making sure, for example, that a liver cell remains a liver cell and does not become a neuron.

Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor required for liver development and the control of expression of liver - specific genes, and it is associated with several critical metabolic pathways [3].

Both genes turned out to be «transcription factors,» proteins that control how and when other genes are turned on or off.

PULLMAN — Researchers at Washington State University have identified a new class of DNA sequence variation in gene promoter regions that could help control the activity of genes.The novel variations, dubbed «multiple nucleotide length polymorphisms,» or MNLPs, altered transcription of the genes they were associated with as much as 11-fold.

Genes under LITE control showed a rise in transcription in as little as 30 minutes after light stimulation.

Using novel gene - array technology to measure the extent of gene expression in thousands of genes simultaneously, this study shows that as humans diverged from their ape ancestors in the last five million years, genes for transcription factors — which control the expression of other genes — were four times as likely to have changed their own expression patterns as the genes they regulate.

The Wnt target gene encoding the transcription factor Achaete scute - like 2 controls the fate of the intestinal stem cell (26).

Dr. Loftus» current research integrates the identification of these types of epigenetic modifications that mark the melanocyte regulatory genomic landscape with regulatory protein and transcription factor chromatin - binding domains, thus defining groups of non-coding DNA sequences utilized in the control of melanocyte gene expression.

In vivo studies have previously shown that Saccharomyces cerevisiae ribosomal protein (RP) gene expression is controlled by the transcription factor repressor activator protein 1 (Rap1p) in a

Transcription factors dictate what genes are turned on or off in a cell during embryo formation, thereby controlling the type of organ the cell will form.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Here, we identify three additional novel mutant alleles of the SHELL gene, which encode a type II MADS - box transcription factor, and determine oil yield via control of shell fruit form phenotype in a manner similar to two previously identified mutant SHELL alleles.

Once again, the genes that are subject to HAR2 regulation are still unclear, although GBX2, a transcription factor that controls proper expression of genes involved in embryo morphogenesis, is one promising candidate.

The bromodomain containing protein 9 (BRD9) has been reported as a component of the switch / sucrose non-fermentable (SWI / SNF) brahma - related gene 1 - associated factor (BAF) complex, which plays a key role in chromatin remodelling and transcription control [1] although the precise biological role is unknown.

In a developing embryo, for example, a researcher could determine whether or not newly synthesized or long - lived transcription factors control gross changes in gene expression as new body sections are formed.

The regulatory system of these cells consists basically of proteins called transcription factors that control the activity of many genes — which in turn comprise the molecular machinery that instructs cells to develop into their mature, functioning state.

Control of plastid gene expression: 3 ′ inverted repeats act as mRNA processing and stabilizing elements, but do not terminate transcription

Dmrt1 (Doublesex and mab - 3 related transcription factor 1) is a testis - specific gene and actin was used as a loading control.

DAXX associates with RelB, a transcription factor of the NF - κB family that directly controls the expression of numerous apoptosis - and autophagy - relevant genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].

FoxP2 is a transcription factor, thus the mechanism by which it exerts its function (s) is through control of downstream genes.

To gain insight into how mammalian gene expression is controlled by rapidly evolving regulatory elements, we jointly analysed promoter and enhancer activity with downstream transcription levels in liver samples from 15 species.