Not exact matches
The two proteins that
control your
gut - lining
permeability — occludin and zonulin — also
control your blood - brain barrier
permeability, and when they are elevated, it can lead to both leaky
gut and leaky brain.
Healthy male volunteers (n = 7) participated in a randomized crossover trial comparing changes in
gut permeability (lactulose / rhamnose ratios) before and after 5 days of 50 mg of indomethacin three times daily (tds) per oral with colostrum (125 ml, tds) or whey protein (
control) co-administration.
A second study examined the effect of colostral and
control solutions (125 ml, tds for 7 days) on
gut permeability in patients (n = 15) taking a substantial, regular dose of an NSAID for clinical reasons.
In volunteers, indomethacin caused a 3-fold increase in
gut permeability in the
control arm (lactulose / rhamnose ratio 0.36 + / -0.07 prior to indomethacin and 1.17 + / -0.25 on day 5, P < 0.01), whereas no significant increase in
permeability was seen when colostrum was co-administered.
«This could manifest, behaviorally, via magnified antioxidant and anti-inflammatory activity, reduction of intestinal
permeability and the detrimental effects of LPS, improved glycemic
control, positive influence on nutritional status (and therefore neurotransmission and neuropeptide production), direct production of GABA, and other bioactive chemicals, as well as a direct role in
gut - to - brain communication via a beneficial shift in the intestinal microbiota itself.»