Sentences with phrase «control mechanisms of cancer»

Not exact matches

These results have important implications for the understanding of the mechanisms controlling tumour heterogeneity and the development of new strategies to block PIK3CA induced breast cancer.

One of the key questions in cancer biology is to understand the mechanisms that control tumor heterogeneity and to determine to which extend tumor heterogeneity influences clinical outcome.

«We are asking the body to override these existing control mechanisms,» says Mark Kelley of Vanderbilt - Ingram Cancer Center in Nashville, Tenn., who was involved with the failed Canvaxin studies.

Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME - ON (Genetic Associations and Mechanisms in Oncology) network, the team compared telomere lengths with the risk of developing breast, lung, colorectal, ovarian and prostate cancers, including subtypes.

«Next steps are to further explore this possibility in human trials in order to assess if it will help patients, but these two drugs make sense from a variety of studies and we find that they act together through multiple mechanisms to control cancer growth in the laboratory.»

Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer Metastasicancer cells to leave the latent state and even less is known in patients,» explains Roger Gomis, head of the Growth Control and Cancer MetastasiCancer Metastasis Lab.

In one of nature's mixed blessings, the mechanisms that work to heal cuts and wounds, rebuilding damaged cells, can also go out of control and cause cancer.

Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.

Jean - Christophe Larsimont and colleagues used state of the art genetic mouse models to dissect the functional role and molecular mechanisms by which Sox9 controls skin cancer initiation and invasion.

«Pin1 changes protein shape through proline - directed phosphorylation, which is a major control mechanism for disease,» explains co-senior author Kun Ping Lu, MD, PhD, Director of Translational Therapeutics in the Cancer Research Institute at BIDMC and Professor of Medicine at Harvard Medical School who co-discovered the enzyme in 1996.

These include, for example, the mechanisms behind stem - cell development and what happens when normal cellular growth spirals out of control, such as in cancer.

Published in the May 1 edition of Cancer Research, the study supports a critical role for IGF - 1R signaling in prostate - tumor development and identifies an important IGF - 1R - dependent growth control mechanism, according to the authors.

Over the years, Dr. Nimer has conducted extensive clinical and basic science research into the treatment and genetic basis of adult leukemia and bone marrow failure states, defining the regulatory mechanisms that control the production of blood cells and exploring ways to improve the treatment of blood based cancers.

Adrian R. Krainer Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases; alternative splicing; RNA - protein interactions; cancer

We are unraveling the mechanisms of this modulation in different solid and hematological malignancies and investigating ways to potentiate iNKT cell control of the tumor microenvironment for cancer immunotherapy.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

In tumors, the clockwork genetic mechanisms that control the life cycle of cells are entirely disrupted, a fact that may hold the key to defeating cancer.

The question of how cellular behavior is controlled is at the center of stem cell biology, and understanding the mechanisms of cell fate regulation is key for treating diseases that occur upon dysregulation, such as cancer or diabetes.

Ultimately, the reeducation of stromal cells to recover the control mechanisms responsible for normal tissue homeostasis might be an innovative strategy to support the current cancer treatments.

Dissecting these interactions with a combination of cell - biology and systems biology approaches should allow uncovering the tissue specific control mechanisms that are defective in cancer.

More recently, we have learned that it is critical to understand the biology of cancer plasticity to identify the mechanisms that allow tumours to resist or escape immune control.

Dysfunction of these mechanisms drives diseases such as cancers, in which social controls on multicellularity fail, and autoimmune disorders, in which distinctions between self and non-self are disrupted.

the metabolism of cancer cells, the responses of cancer cells to stress, and mechanisms involved in control of the cell cycle

Here, we review the current state of the art of somatic cancer evolution and mechanisms of immune control and escape.

It's considered that this is a component of the mechanism driving out of control cell division and cancer growth.

It could be that IGF - 1 still matters while a person already has cancer regardless of vitamin d or any of its other cofactors, but the evidence for a causal relationship between serum IGF - 1 and incidence of cancers in the presence of good control for IGF - 1 receptors has been called into question and is supported by well - known mechanisms.

In this way, the act of fasting will reduce the very mechanism that cancer cells use to take control.

Studies on cruciferous vegetables and cancer prevention have not typically focused on vitamin K per se, but we suspect that the amazing K content of cruciferous vegetables is definitely related to their cancer - preventive properties through mechanisms involving better control of inflammation.

Viewing cancer as a metabolic disease — opposed to a disease of damaged DNA, which is a downstream effect of mitochondrial dysfunction — gives us the power to control this dysfunction by carefully choosing foods and nutrients and employing strategies that help optimize the biochemical pathways that suppress cancer growth while simultaneously stimulating mechanisms to push it into remission.

Iodine controls apoptosis, programmed death of abnormal cells, and is part of the body's surveillance mechanism against cancer.

That is, simple adjustment of dietary protein (casein) within very normal ranges of protein intake controlled cancer growth and it worked not by one mechanism but by a large array of mechanisms.