Sentences with phrase «control of action potential»

The work combines remote control of action potential firing and synaptic signaling combined with imaging of activity with genetically encoded calcium and voltage sensors and electrophysiology.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

HACCP is used in the food industry to identify potential food safety hazards, so that key actions, known as Critical Control Points (CCP's) can be taken to reduce or eliminate the risk of the hazards being realized.

Recognizing the fluid and quick changing nature of potential legislation on gun control, the Executive Officers of NYSACC are hereby authorized to issue a letter of opposition for any bill that attempts to enact the above mention actions.

«By revealing the dynamics of facial action through machine vision systems,» said Bartlett, «our approach has the potential to elucidate «behavioral fingerprints» of the neural - control systems involved in emotional signaling.»

Drugs that can block or inhibit the action of PTP1B have enormous potential in controlling diabetes and obesity.

The researchers» findings contribute to the mechanistic understanding of how the machinery required to initiate and propagate action potentials of neurons are controlled at the level of alternative splicing — a very tiny piece of the neuronal maturation puzzle, but one that has a significant impact.

The potential relevance of eye movement in individuals with Autism is the area of the brain that controls these actions, a densely - packed structure of neurons known as the cerebellum.

«We found that, during periods of recurrent network activity, cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.»

YanGang Sun, Juan Pita - Almenar, Chia - Shan Wu, John J Renger, Victor N. Uebele, Hui - Chen Lu, Michael Beierlein (2013) «Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons», Journal of Neuroscience 33: 2048 - 59.

The concept of a squad - based action / shooter done in a style similar to some of the older classics like Contra and Ikari Warriors is a fair one, but the frustrations of control and the indistinct visuals take away any potential there might have been.

And one must remain skeptical whether any democratically controlled school system could accommodate the explosive potential of action civics as she describes it.

Applying this understanding to the way you drive this car is crucial to unlocking its performance potential on challenging roads, providing you with the feeling that you're not just controlling the action but are an intricate part of it, too.

(39 kg) raise the child into the adult belted zone • Anti-lock brakes (ABS) modulate the brakes for the driver to provide steering control while braking • Electronic Stability Program (ESP) applies selective braking or throttle reduction to control oversteer and understeer • Brake Assist ensures maximum braking action during panic stops • Traction Control reduces the throttle and / or applies selective braking to optimize traction during acceleration • Electronic Roll Mitigation determines when the vehicle is in a potential roll over condition and applies appropriate braking force to reduce the likelihood that such an event will occur • Rollover Sensing deploys seat - mounted side air bags, side - curtain air bags and seat - belt pretensioners • Trailer Sway Control helps maintain vehicle and trailer system stability by applying selective braking • Event Data Recorder records the nature of a malfunction or impact event for retrieval using a service diagnostic tool • Available ParkView ™ Rear Backup Camera displays the view behind the vehicle in the navigation display when backing up or parking • Tire Pressure Monitoring (TPM) alerts drivers to low tire pressure (s) to facilitate safe handling • Brake - park Interlock prevents automatic transaxle from being shifted out of Park or Neutral without first applying brakes • Side Guard Door Beams in front and rear doors provide occupant protection in the event of a sidecontrol while braking • Electronic Stability Program (ESP) applies selective braking or throttle reduction to control oversteer and understeer • Brake Assist ensures maximum braking action during panic stops • Traction Control reduces the throttle and / or applies selective braking to optimize traction during acceleration • Electronic Roll Mitigation determines when the vehicle is in a potential roll over condition and applies appropriate braking force to reduce the likelihood that such an event will occur • Rollover Sensing deploys seat - mounted side air bags, side - curtain air bags and seat - belt pretensioners • Trailer Sway Control helps maintain vehicle and trailer system stability by applying selective braking • Event Data Recorder records the nature of a malfunction or impact event for retrieval using a service diagnostic tool • Available ParkView ™ Rear Backup Camera displays the view behind the vehicle in the navigation display when backing up or parking • Tire Pressure Monitoring (TPM) alerts drivers to low tire pressure (s) to facilitate safe handling • Brake - park Interlock prevents automatic transaxle from being shifted out of Park or Neutral without first applying brakes • Side Guard Door Beams in front and rear doors provide occupant protection in the event of a sidecontrol oversteer and understeer • Brake Assist ensures maximum braking action during panic stops • Traction Control reduces the throttle and / or applies selective braking to optimize traction during acceleration • Electronic Roll Mitigation determines when the vehicle is in a potential roll over condition and applies appropriate braking force to reduce the likelihood that such an event will occur • Rollover Sensing deploys seat - mounted side air bags, side - curtain air bags and seat - belt pretensioners • Trailer Sway Control helps maintain vehicle and trailer system stability by applying selective braking • Event Data Recorder records the nature of a malfunction or impact event for retrieval using a service diagnostic tool • Available ParkView ™ Rear Backup Camera displays the view behind the vehicle in the navigation display when backing up or parking • Tire Pressure Monitoring (TPM) alerts drivers to low tire pressure (s) to facilitate safe handling • Brake - park Interlock prevents automatic transaxle from being shifted out of Park or Neutral without first applying brakes • Side Guard Door Beams in front and rear doors provide occupant protection in the event of a sideControl reduces the throttle and / or applies selective braking to optimize traction during acceleration • Electronic Roll Mitigation determines when the vehicle is in a potential roll over condition and applies appropriate braking force to reduce the likelihood that such an event will occur • Rollover Sensing deploys seat - mounted side air bags, side - curtain air bags and seat - belt pretensioners • Trailer Sway Control helps maintain vehicle and trailer system stability by applying selective braking • Event Data Recorder records the nature of a malfunction or impact event for retrieval using a service diagnostic tool • Available ParkView ™ Rear Backup Camera displays the view behind the vehicle in the navigation display when backing up or parking • Tire Pressure Monitoring (TPM) alerts drivers to low tire pressure (s) to facilitate safe handling • Brake - park Interlock prevents automatic transaxle from being shifted out of Park or Neutral without first applying brakes • Side Guard Door Beams in front and rear doors provide occupant protection in the event of a sideControl helps maintain vehicle and trailer system stability by applying selective braking • Event Data Recorder records the nature of a malfunction or impact event for retrieval using a service diagnostic tool • Available ParkView ™ Rear Backup Camera displays the view behind the vehicle in the navigation display when backing up or parking • Tire Pressure Monitoring (TPM) alerts drivers to low tire pressure (s) to facilitate safe handling • Brake - park Interlock prevents automatic transaxle from being shifted out of Park or Neutral without first applying brakes • Side Guard Door Beams in front and rear doors provide occupant protection in the event of a side impact

The balance is between the insured's right to a full and fair defence of the civil action against it and the insurer's right to control that defence because of its potential ultimate obligation to indemnify.

Production Line Worker — ABC Manufacturing — St. Louis, MO — 6/2013 to Present • Stand for over eight hours and handle equipment weighing up to 80 pounds everyday • Inspect and analyze production line units to predict potential obstacles and recommend preventative action, resulting in a 10 percent increase in daily productivity • Assist with the loading, unloading, and organization of production equipment and finished products • Follow safety protocols and meet environmental codes while maintaining a consistently high and accurate production rateProduction Line Worker — Econ Developments — St. Louis, MO — 9/2008 to 6/2013 • Worked individually and within the production line crew to fabricate and install various pieces on a daily basis • Performed assembly with a 95 percent accuracy rate, the highest in the company • Reported daily production numbers and machinery malfunctions to the factory supervisor • Completed quality control checks upon product completions and helped sort and load orders for shipping

Accounting Professional — Duties & Responsibilities Develop and maintain a strong and extensive working knowledge of various accounting principles, regulations, tax codes and related applications, continuously applying shifts in the accounting landscape to current responsibilities and client situations Manage important and sensitive financial documents, receipts and invoices on a daily basis, providing organization for audit assistance and execution as well as compliance with various accounting standards Execute various functions and tasks including risk management, discrepancy analyses and resolution, compliance and controls, transaction accounting and other critical functions Perform analysis, research and evaluation of current accounting policies and procedures, providing thorough presentation on the potential positive and negative impacts of any modifications to present strategies Facilitate the efficiency and implementation of all accounting operations from concept to execution, partnering with clients to understand, assess and resolve current financial - and accounting - related issues Utilize technological resources, including software and accounting applications, to execute all aspects of both corporate and personal accounting as well as prepare, audit and file important and sensitive tax documents with appropriate authorities Employ in - depth knowledge of the Internal Revenue Code, IRS, SOX, audit executions, strategy development, financial statement development and maintenance, tax filings and other critical functions Work closely with clients to develop specific plans - of - action to address future taxation and accounting issues, collaborating with other professional advisors as needed Understand and apply accounting and financial reporting standards (GAAP), rules and regulations, and FASB statements Address and resolve client queries and issues in an expedited manner while delivering personalized and professional service Ensure adherence to professional codes of conduct, applicable rules and regulations, laws and other relevant benchmarks