Sentences with phrase «controlled clinical trial studying»

Motivated by their previous finding of the presence of P - glycoprotein overexpression in the nasal lining of patients with CRS with nasal polyps, the study authors conducted a randomized, double - blind, placebo - controlled clinical trial studying the use of low - dose Verapamil in 18 patients with CRS with nasal polyps.

Not exact matches

Last year The Ohio State University Wexner Medical Center began clinical trials on the efficacy of SuperBetter to treat traumatic brain injuries, and the University of Pennsylvania Positive Psychology Center greenlighted a randomized controlled user study of the game to treat depression.

Besides randomized controlled clinical trials, there are a number of ways researchers can study how a particular cancer treatment is playing out in the real world: there are retrospective studies, observational studies, and even prospective research done using patient registries.

First, the topline numbers: The study was an observational one rather than a randomized control trial, the latter of which is considered to be the «gold standard» of clinical studies.

Much of the evidence against BPA comes from large population studies rather than controlled clinical trials.

Controlled clinical trials and observational studies including an internal comparison group

This study is a randomized clinical trial (RCT) with 50 mother / infant pairs in the intervention arm, 50 in one control group and 25 in a third control group.

This study is the first controlled clinical trial showing that fathers play a significant role in supporting successful lactation and increasing breastfeeding rates.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

The epidemiological evidence was strong enough that it led to a whole series of clinical studies and randomized control trials with fish oil, says nutritionist Penny M. Kris - Etherton of Pennsylvania State University.

And the Sanofi Pasteur study was a randomized, controlled, blinded trial — the gold standard in clinical research.

The new study is a meta - analysis of three randomized controlled trials conducted by the Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GItrials conducted by the Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GITrials in Oncology (formerly Cancer and Leukemia Group B)(CALGB) with support from the NCI, Intergroupe Francophone du Myélome (IFM), and the Gruppo Italiano Malattie Ematologiche dell «Adulto (GIMEMA).

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

... Finally, this study draws attention to the need for large controlled clinical trials to determine if a combination of fall prevention strategies and treatment with bone - active drugs might produce additive benefits on fractures, especially in high - risk populations such as those living in nursing homes.

The resveratrol clinical trial was a randomized, phase II, placebo - controlled, double blind study in patients with mild to moderate dementia due to Alzheimer's disease.

The study analyzed data from three randomized, controlled clinical trials conducted between 2001 and 2015 called INFANT, PEAK and MIST that included 736 children.

The study, a retrospective survival analysis, included 229 patients who participated in two randomized, controlled clinical trials focused on relief of constipation for patients receiving palliative care for various types of late - stage cancer and other terminal diseases.

Earlier observational studies had shown a similar impact of ARVs reducing sexual transmission in heterosexual couples, but this was the first to demonstrate the prevention power of the drugs in a randomized, controlled clinical trial.

The STAR trial was conducted under controlled conditions, while the Penn study takes the next step by looking at outcomes in post-approval clinical use of the device.

The gold standard in clinical trials is a randomised, placebo - controlled study.

Non-controlled, observational study comparing outcomes of non-study patients to those participating in a controlled clinical trial.

The authors concluded that although the studies included in this review provided important information, double - blinded, sham - controlled phase II and phase III clinical trials with larger sample sizes are needed to validate this novel therapeutic approach.

The median overall survival of patients in the Phase 1 resection injection study, where Toca 511 was injected into the wall of the resection cavity after removal of the tumor, exceeds historical controls across a variety of previously reported clinical trials.

«In keeping with a similar randomized clinical trial previously published in the Lancet and conducted by researchers in Rome in collaboration with us here at King's College London, the STAMPEDE study shows that even patients that after 5 years experienced relapse of diabetes after initial and complete remission of the disease continue to maintain excellent control of their blood sugar levels with minimal or no need for glucose lowering drugs.

In 2009, The Clinical Trials Network (CTN) Scanner Validation Program was established to ensure baseline common quality control metrics for PET scanners used in multi-center studies.

Study in partnership with the Alliance for Clinical Trials in Oncology is the first large controlled trial to show overall survival benefit in FLT3 - mutated AMLAML is the most common acute leukemia in...

Here, we sequentially conducted both a case - control study and a clinical trial to investigate the potential effects of oxytocin on this difficulty at behavioural and neural levels measured using functional magnetic resonance imaging during a psychological task.

The ECOG - ACRIN Cancer Research Group contains an Imaging Core Laboratory to support a wide range of clinical trials associated with imaging that are developed across the Group's three scientific programs: Cancer Control and Outcomes, Therapeutic Studies, and Biomarker Sciences.

While there have been a number of human clinical studies, we need larger, randomized, properly - controlled clinical trials that look specifically at these suspects.

As scientists use tools like EGG / ECGs, MRI imaging, and controlled clinical trials to study and explain why tapping works, I am more convinced EFT has a solid foundation no matter your religion or worldview.

In a study published in 1999, A placebo - controlled clinical trial of L - tryptophan in premenstrual dysphoria, tryptophan was found to reduce symptoms of PMS when used in the luteal phase or second half of the cycle (i.e. after ovulation)

In Part I of this article, evidence from a wide range of peer - reviewed research, including in vitro and in vivo studies, clinical and randomized controlled trials, epidemiological studies, meta - analyses and reviews, was presented.

Dr. Neil Barnard's study «A Low - Fat Vegan Diet Improves Glycemic Control and Cardiovascular Risk Factors in a Randomized Clinical Trial in Individuals With Type 2 Diabetes» Diabetes Care 29:1777 — 1783, 2006 on the effects of a WFPB diet on people who have type 2 diabetes showed a WFPB diet was more effective than the diet recommended by the American Diabetes Association (ADA)(hardly a meat heavy diet).

Some important studies include: • Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men (1976) • Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise (1982) • Diet and exercise in the treatment of NIDDM: The need for early emphasis (1994) • Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a low fat, vegetarian diet (1999) • The effects of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity (2005) • A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes (2006) • A low - fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial (2009) • Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes (2011) • Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet (2012)

The U.S. National Institutes of Health counts 135 registered trials of curcumin in the last 15 years, according to the study authors, but not one double - blind, placebo - controlled clinical trial on curcumin can support all of the benefits we've been attributing to it, and when it comes to research that seemed to prove curcumin's effects on pancreatic and colon cancers, Alzheimer's disease, and radiation - induced rashes, it seems that the supposed benefits are all cracked up.

In a new study published in Pharmacopsychiatry, Crocus sativus L. versus citalopram in the treatment of major depressive disorder with anxious distress: a double - blind, controlled clinical trial, saffron (Crocus sativus L.) has been shown to have both antidepressant and antianxiety effects.

I do not necessarily recommend it because I have seen excellent clinical results from a strict plant based diet A multicenter randomized controlled trial of a plant - based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO study.

The study was a randomized, double - blind, controlled clinical trial.

In a clinical trial, the study controls the dietary intake, which is more complicated than in observational studies where the participants control their own diet.

Whereas enthusiasm for fasting is increasing, clinical relevance remains low because of insufficient human data, including almost nonexistent controlled trials (21, 33 — 36), few clinical outcomes studies (37, 38), lack of correction for inflated type I error rates from multiple hypothesis tests, and limited safety data (39 — 41).

Filters were also used for «humans» to eliminate animal studies and — for aim 1 — «clinical trial» to eliminate clinical studies that did not have a control arm.

Design: A systematic review of the published literature through January 2015 was performed by using sensitive search strategies to identify randomized controlled clinical trials that evaluated the effects of fasting on either clinically relevant surrogate outcomes (e.g., weight, cholesterol) or actual clinical event endpoints [e.g., diabetes, coronary artery disease (CAD)-RSB- and any other studies that evaluated the effects of fasting on clinical event outcomes.

Whereas the few randomized controlled trials and observational clinical outcomes studies support the existence of a health benefit from fasting, substantial further research in humans is needed before the use of fasting as a health intervention can be recommended.

Furthermore, Asensia ®'s formula has been used safely for more than 12 years with over a million bottles sold and studied in a double - blind placebo controlled clinical trial.

In order to have a valid scientific clinical trial study, it must be randomized, double blind, placebo controlled and with meta - analysis.

The Effects of L - theanine (Suntheanine ®) on Objective Sleep Quality in Boys with Attention Deficit Hyperactivity Disorder (ADHD): A Randomized, Double - blind, Placebo - controlled Clinical Trial Alternative Medicine Review 2011 (Dec); 16 (4): 348 — 354 ~ FULL TEXT This study demonstrates that 400 mg daily of L - theanine is safe and effective in improving some aspects of sleep quality in boys diagnosed with ADHD.

About the Study The study, «Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis,» was conducted as a double - masked, placebo - controlled clinical trial aimed to evaluate the safety and efficacy of APOQUEL compared with plaStudy The study, «Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis,» was conducted as a double - masked, placebo - controlled clinical trial aimed to evaluate the safety and efficacy of APOQUEL compared with plastudy, «Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis,» was conducted as a double - masked, placebo - controlled clinical trial aimed to evaluate the safety and efficacy of APOQUEL compared with placebo.

The clinical trial comes on the heels of a breakthrough Zoetis - American Humane Association pilot study — Canines and Childhood Cancer: Measuring the Effects of Animal - Assisted Therapy for Pediatric Oncology Patients, Their Parents and Therapy Dogs — that confirmed the feasibility of conducting a randomized control trial using AAT in multiple settings.

Work hand - in - hand with clinical trial managers and document control personnel to manage documents that are related to the clinical study.