Sentences with phrase «controlled expression levels»

Despite having tightly controlled expression levels, little is known about how miRNAs themselves are regulated because their genes are poorly defined.

«If we target the very beginning of the pathway, we can control the expression levels of the inflammation factors,» he said.

Not exact matches

Perusing the index of Origins, the weekly publication of representative documents and speeches compiled by Catholic News Service, our imaginary historian will note, for example, the following initiatives undertaken at the national, diocesan and parish levels in 1994 - 95: providing alternatives to abortion; staffing adoption agencies; conducting adult education courses; addressing African American Catholics» pastoral needs; funding programs to prevent alcohol abuse; implementing a new policy on altar servers and guidelines for the Anointing of the Sick; lobbying for arms control; eliminating asbestos in public housing; supporting the activities of the Association of Catholic Colleges and Universities (227 strong); challenging atheism in American society; establishing base communities (also known as small faith communities); providing aid to war victims in Bosnia; conducting Catholic research in bioethics; publicizing the new Catechism of the Catholic Church; battling child abuse; strengthening the relationship between church and labor unions; and deepening the structures and expressions of collegiality in the local and diocesan church.

Four suction levels allow for efficient expression, controlled by mom to suit her needs and comfort.

Control: The two dials on the Simplisse pump allow for customized levels of milk expression.

DNA methylation is a mechanism cells use to control gene expression at the epigenetic level.

Hypoxia - inducible factor 1α (HIF - 1α), an oxygen sensor that controls the expression of various genes for glucose metabolism under conditions of low oxygen levels, is the most well documented substrate of the von Hippel - Lindau (VHL) enzyme.

In a study exploring the molecules controlling osteoclast differentiation in the cancer setting, Ell et al. have identified miRNAs (microRNAs are small noncoding RNAs that regulate gene expression) whose levels were consistently down - or up - regulated in differentiating osteoclasts.

RNA polymerase in bacteria controls the expression of all genes, but in response to the presence of ppGpp, the expression levels of some genes are turned down, while many are unaffected and some are turned up.

Remarkably, these brains showed higher levels of DCC expression — some 48 per cent higher when compared to control subjects.

He says conventional approaches often fail because the level of expression of the genes can not be controlled.

«DNA methylation is a key mechanism by which day length and melatonin levels exert seasonal control over the expression of the deiodinase enzyme known as dio3, and dio3 expression likely acts as a key step for the maintenance of reproductive competency during the breeding season,» said co-author Tyler Stevenson, senior lecturer at the Institute of Biological and Environmental Sciences at the University of Aberdeen in Scotland.

They also expressed lower levels of an RNA message that controls the expression of a family of proteins called SOC, known to inhibit the migration of hematopoietic stem cells.

Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.. In this latest work, investigators compared the frequencies of «more active» and «less active» variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients.

Genes involved in microcephaly, a condition in which patients have brains roughly the size of chimpanzee brains, directly control the levels of BRCA1 expression, he says.

They found that the immune cells of 71 HIV - infected subjects had elevated levels of PD - 1 expression compared to uninfected controls.

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

For each species, we chose control genes with high expression levels and little sample - to - sample variability.

Interestingly, we found that at the protein level 2 efflux transporters, namely ABCB1 and ABCC10, were up - regulated and now are also expressed in germ cells, expression that was barely detectable, if at all, in controls.

The ef - 1α (elongation factor - 1 alpha) expression levels did not differ significantly between control and seizure - induced workers at any sampling time, irrespective of the experimental temperature (25 °C or 46 °C; data not shown).

Of the 24 genes downregulated following hypoxia, the expression of approximately half remained lower than control levels after recovery.

Figure 1B shows that after 0.5 h of hypoxia, HIF - 1α protein levels (normalized to levels of β - actin protein expression) were elevated approximately sevenfold relative to the control.

We are examining the effect of a maximal exercise stress test on gene expression, metabolism, inflammatory markers, and cytokine levels in ME / CFS patients and healthy controls.

In control bees kept under anesthesia, there was no significant change in the expression level at any time - point sampled.

In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF - 1α, the regulatory subunit of HIF - 1, and increased VEGF expression have been shown, indicating that HIF - 1 may control the expression of VEGF in the retina under hypoxic conditions.

Finally, mRNA expression of striatal tissue found no differences in BDNF expression although expression of TNF - in the 3 - NP - iPSC - 21 and -42 rats had significantly lower levels than sham control and 3 - NP - iPSC - 7 rats, suggesting that there was not a continuous immune response to iPSCs.

The expression level of α - actin was served as a loading control.

Under those optogenetic controls, gene expression levels reliably increased in vitro by a factor of 10 to 20.

found increased expression levels of genes that are considered to be associated with AD (BACE2, RCAN1, ETS2, TMED10), as compared to healthy controls.

(H) Spleen CD4 + T cells harvested from VPA recipients and control mice on day 21 were analyzed by Western blot assay for the expression and phosphorylation level of Akt and downstream target proteins.

Additionally, we... found increased expression levels of genes that are considered to be associated with AD (BACE2, RCAN1, ETS2, TMED10), as compared to healthy controls.

These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.

The team then compared the proteomics data to sample - matched transcriptomics data to characterize the global control of gene expression at the post-transcriptional level.

While the role that DNA - binding proteins play in regulating gene expression at the transcriptional level is well studied, how RNA - binding proteins control gene expression at the post-transcriptional level is less clear.

Bioinformatics approaches were then used to compare the proteomics data to sample - matched transcriptomics data to identify targets of post-transcriptional control and provide quantitative information on changes in the expression pattern of targets at the level of translation.

To gain insight into how mammalian gene expression is controlled by rapidly evolving regulatory elements, we jointly analysed promoter and enhancer activity with downstream transcription levels in liver samples from 15 species.

ACTB mRNA expression levels in lymphoblastic lines and fibroblasts derived from affected individuals were decreased in comparison to those in control cells.

(B) Liver expression of Apoc3 mRNA levels in mutant mice on a high - fat diet for 6 weeks and treated for the last 5 weeks with control or ApoC - III ASO (n = 3 — 7 / group).

The database will allow users to view and download computed GTEx results and provide a controlled access system for de-identified individual - level genotype, expression, and clinical data through NCBI's database of Genotypes and Phenotypes, at http://www.ncbi.nlm.nih.gov/gap.

New research studies suggest that intermittent fasting helps optimize insulin levels, promote weight loss, facilitate cellular repair and even control gene expression to promote longevity and disease protection.

That genetic expression is, in turn, largely regulated by nutrient level detecting hormones, of which insulin, leptin and mTOR are primary, and they in turn are controlled by what you eat.

[12] Controlled, experimental studies exploring intrinsic motivation of college students has shown that nonverbal expressions of enthusiasm, such as demonstrative gesturing, dramatic movements which are varied, and emotional facial expressions, result in college students reporting higher levels of intrinsic motivation to learn.

You get a decent amount of equipment for your money though, with DAB radio, smartphone compatibility, cruise control, and keyless entry and start included on entry level Expression trim.

In addition to the availability of parking brake assist from the Expression trim level upward, Laguna is the only vehicle on the market to propose a host of safety features - ESP, tyre pressure monitoring system, cruise control with speed limiter, six airbags, etc. - as standard equipment from the entry level.

The most us mere mortals can usually hope for is tackling a level with some small grace, which makes efforts such as this video, of someone perfecting Ikaruga (Radiant Silvergun's spiritual successor) while controlling both ships himself, the ultimate expression of danmaku.

The expression of coloration is extremely tightly controlled at the genetic and molecular levels.

Because of the parents» high levels of anxiety, stress, and need for control, individual expression is discouraged.

In contrast, bullying was not associated with the child's perceived problems regulating anger, suggesting that children with higher levels of bullying admit to expressing anger but consider this emotional expression as being under their control.

In comparison to families of children with learning disabilities and control groups, they perceived their family relations as less conducive to the open expression of emotions, with lower levels of mutual support, and reported their families as more organized and with higher system maintenance orientation [33].

Reduced amygdala responses to fearful facial expressions have been reported in adolescents with CD or conduct problems, and elevated CU traits compared to typically - developing controls (Jones et al. 2009; Marsh et al. 2008), whereas increased amygdala responses to fearful faces have been demonstrated in children with conduct problems and low levels of CU traits compared with their high CU traits counterparts (Viding et al. 2012).