Not exact matches
Last year The Ohio State University Wexner Medical Center began clinical trials on the efficacy of SuperBetter to treat traumatic brain injuries, and the University of Pennsylvania Positive Psychology Center greenlighted a
randomized controlled user
study of the game to treat depression.
Besides
randomized controlled clinical trials, there are a number of ways researchers can
study how a particular cancer treatment is playing out in the real world: there are retrospective
studies, observational
studies, and even prospective research done using patient registries.
First, the topline numbers: The
study was an observational one rather than a
randomized control trial, the latter of which is considered to be the «gold standard» of clinical
studies.
The
randomized study aimed to determine if the Medisafe smartphone app could improve self - reported medication adherence and blood pressure
control among hypertension patients.
In September 2016, the authors of the
randomized -
controlled trial of Living Goods program posted a discussion paper on the
study (archived version).
A 2001 double - blind
study at the Mayo Clinic
randomized 799 discharged coronary surgery patients into a
control group and an intercessory prayer group, which received prayers at least once a week from 5 intercessors per patient.
O'Laoire S. Abstract DESIGN:
Randomized,
controlled, double - blind
study.
Another more recent
study assessed the efficiency of collagen peptides in a
randomized, double blind,
controlled multicenter trial, in which 250 subjects with primary osteoarthritis of the knee were given 10g of collagen peptides daily.
Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta - analysis of
randomized controlled trials and prospective cohort
studies, CMAJ, vol.
[1] Lugo JP, et al. «Efficacy and tolerability of an undenatured type ll collagen supplement in modulating knee osteoarthritis symptoms: a multicenter
randomized, double - blind, placebo -
controlled study.»
Methods: This
randomized, double - blind, placebo -
controlled, prospective follow - up
study involved 90 coeliac disease patients in remission
randomized to consume glucose syrups, maltodextrins or placebo for 24 weeks.
This observation has precipitated numerous observational
studies and
randomized controlled trials of the effect of added sugars or SSB consumption on body weight and cardiovascular disease risk factors (6, 8, 9).
The Nurse - Family Partnership has been
studied in three separate
randomized controlled trials, which have shown positive effects on the mothers, including reduced incidence of child abuse, arrest, and welfare enrollment.
For the same reason, it is not easy to prove treatment efficacy by means of
controlled,
randomized studies, the «gold standard» for evaluating new therapies.
• In another
randomized controlled study of an intervention designed to reduce smoking in expectant fathers, addressing the mothers alone resulted in 5 % of the fathers» quitting, while addressing the father directly resulted in a 15 % quit rate (McBride et al, 2004).
Alexandrovich I, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S. «The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a
randomized, placebo -
controlled study.»
This
study employed accepted research methodology, including a
randomized control group and a sufficient sample size.
The most recent findings of the Belarus
study (an excellent, large scale,
randomized, first world
study) were recently published and show that 11 year - olds have a 17 % GREATER chance of being obese or overweight if they were in the breastfeeding group than in the
control group.
There has never been a
randomized, prospective,
controlled study in humans on cigarette smoking, but we have still been able to determine that it causes lung cancer.
The number of
randomized, blinded,
controlled studies (the highest quality clinical research) is less than 5.
He points to research by a Stanford University researcher, Allan K. Mishra, who has
studied PRP for years, whose in his most recent published research includes a large multicenter
study [8] involving a host of well - respected orthopedic surgeons around the country who followed 230 patients in a double - blind
randomized control study [the gold standard for medical research].
In 2007, researchers published the first
randomized,
controlled study of the effect of being raised in an orphanage; that
study, and subsequent research on the same sample of Romanian orphans, found that compared with babies placed with a foster family, those who were sent to institutions had lower IQs, slower physical growth, problems with human attachment and differences in functioning in brain areas related to emotional development.
Primarily because we do not find the same benefits in better - designed
studies — sibling comparison
studies and the PROBIT
randomized controlled trial.
Comparing the Kangaroo care method with standard incubator care, a
randomized control study published in the magazine «Annals of Tropical Pediatrics» found that the former is by far superior.
The latest
study, published in Hypertension, a journal of the American Heart Association, was a
randomized controlled trial.
REVIEW METHODS: We included systematic reviews / meta - analyses,
randomized and non-
randomized comparative trials, prospective cohort, and case -
control studies on the effects of breastfeeding and relevant outcomes published in the English language.
In the only
controlled,
randomized scientific
study to compare graduated extinction and «positive routines» head - to - head, there were no significant differences in treatment outcomes for kids (Adams and Rickert 1989).
As with neurobehavior, effects on breastfeeding are poorly
studied, and more recent
randomized controlled trials comparing exposure to epidural and opiate drugs are especially misleading because opiates have a well - recognized negative effect on early breastfeeding behavior and success.103 — 107
We have
randomized controlled trials and observational
studies.
But this doesn't make sense for everything we do in health care, and we know the information we get from
randomized controlled trials doesn't always translate well to real life because 1) the restrictions we put on eligibility for
studies rarely allows the results to be generalized to the population as a whole and 2) Adherence to the intervention tends to be higher in a
randomized controlled trial than in real life which makes the effect seem «better» than it is.
In addition, a number of
randomized controlled studies in different countries are underway, examining the effects of the NBO on a range of outcomes.
In the evidence pyramid a
randomized controlled trial is the highest form of primary research, and a synthesis of
studies provides the best evidence.
Note that the
studies used to arrive at these conclusions are mostly
randomized controlled trials in which the women who agree to participate are randomly assigned to either epidural or non-epidural pain relief.
Another problem for
randomized controlled trial with hydrotherapy is the inability to «blind» the
study.
A 2005 meta - analysis of six
randomized control trials (the gold standard for medical
studies) found that nipple stimulation increases the likelihood of labor.
Hendrix et al: Moving on to section II, labeled
Randomized Controlled Trials (RCTs), I am once again wondering how RCTs can be ethically conducted to
study birthplace.
Research shows that families typically receive roughly half of the number of home visits expected.16, 17 For example, across three
randomized controlled trials conducted of Nurse Family Partnership, average dosage of visits ranged from 45 to 62 percent.18 Research also shows that many, perhaps most, families enrolled in home visiting programs drop out before their eligibility ends.16, 19,20 Some home visiting
studies have varied the dosage that families were offered and found that fewer home visits produced outcomes similar to higher levels of exposure.21
A prospective,
controlled study of the effect of breast milk on infection among low birth weight infants was conducted in India in 1981.18 Although the sample size was small, 62 infants, the
study design was a
randomized block design in which feeding schedules for breast milk or formula were randomly allocated within groups of infants that were determined to be relatively homogeneous with respect to factors predisposing to infection.
Studies of the Nurse Family Partnership model followed children to 6 years and found significant program effects on language and cognitive functioning as well as fewer behaviour problems in a
randomized controlled trial
study.24 In addition, more recent evaluations of Healthy Families America have shown small, but favourable effects on young children's development.25, 26
One
randomized controlled trial comparing home - visited families with
control participants who received other community services found a statistically significant difference in mean depressive symptoms at two years post-enrollment, but this contrast was nonsignificant at three years post - enrollment.15 A second
study of Early Head Start found no differences in depressive symptoms between intervention and
control group participants post-intervention, although a difference was detected at a longer - term follow - up prior to children's enrollment in kindergarten.10 Other
randomized controlled trial
studies have not found effects of home visitation on maternal depressive symptoms.12, 16,17
A series of
randomized control trials of a nurse home visitation program show a range of positive effects on maternal health, including decreases in prenatal cigarette smoking, fewer hypertensive disorders in pregnancy, and fewer closely spaced subsequent pregnancies., A
randomized control study of another program that works with a particularly high - risk population found that participant mothers showed significantly lower depressive symptoms than those in the
control group and were less likely to report feeling stressed a year after participation.
«It is crucial that we have more
randomized controlled trials on interventions to increase breastfeeding rather than relying on heavily confounded observational
studies or biased expert opinion.»
A double - blind,
randomized, placebo
controlled study on the influence of carbohydrate solution intake during labour.
Regarding the science criticism, it's impossible to scientifically prove by a placebo -
controlled, double - blind,
randomized study (the gold standard in science) that AP works better than a more distant style of parenting.
We hypothesized that: (a) detection of HR by auscultation or palpation will vary by more than 15 BPM from actual HR; and (b) the inability to accurately determine HR will be associated with errors in management of the neonate during simulated resuscitation.Using a prospective,
randomized,
controlled study design, 64 subjects participated in three simulated neonatal resuscitation scenarios.
The aim of this
study was to evaluate adherence to the Neonatal Resuscitation Program algorithm by subjects working from memory as compared to subjects using a decision support tool that provides auditory and visual prompts to guide implementation of the Neonatal Resuscitation Program algorithm during simulated neonatal resuscitation.Healthcare professionals (physicians, nurse practitioners, obstetrical / neonatal nurses) with a current NRP card were
randomized to the
control or intervention group and performed three simulated neonatal resuscitations.
To estimate whether prophylactic antibiotics at the time of repair of third - or fourth - degree perineal tears after vaginal delivery prevent wound infection and breakdown.This was a prospective,
randomized, placebo -
controlled study.
This
study is still the largest
randomized control trial done to date on HFA.
These
studies were prospective and minimized selection bias (
randomized controlled trials on this topic are not practical on ethical grounds).
We are «early adopters» of new technologies, if we strongly believe that they appear promising, and if there are good
randomized,
controlled studies that prove they provide a benefit.