Sentences with phrase «controlled tumors in mouse»

The systemic response to surgery triggers the outgrowth of distant immune - controlled tumors in mouse models of dormancy

Not exact matches

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrateIn addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstratein which the anti-cancer properties of capsaicin were solidly demonstrated.

In the mice that received GD2 CAR - T cells, the DIPG tumors were undetectable after 14 days, while mice receiving the control treatment had no tumor regression.

When injected with cancer cells, animals housed there developed tumors 80 % smaller than those in control mice, or no tumors at all.

Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

For the animal study, the researchers separated 52 mice with colon cancer tumors into three groups, including a control group and groups that were fed either the grape compounds or sulindac, an anti-inflammatory drug, which was chosen because a previous study showed it significantly reduced the number of tumors in humans.

In animal models, the modified T cells greatly reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

In the experiment, that conversion wasn't tightly controlled; somewhat creepily, the mice developed tumors that resembled embryos.

When the researchers administered MCB - 613 to 13 mice with breast cancer, the drug candidate almost completely eliminated tumor growth without causing toxicity, whereas tumors continued to grow by about 3-fold over 7 weeks in the control group of 14 mice.

The tumors grew rapidly in the control experiments (the median time for tumor - free survival was one week) and any differences in tumor - free survival for the controls and the mice injected with cells expressing mutated PREX2 were not statistically significant (Horrigan et al., 2017).

In the replicating lab, however, tumors grew extremely slowly in both treated mice and in controls — and in a few cases spontaneously regresseIn the replicating lab, however, tumors grew extremely slowly in both treated mice and in controls — and in a few cases spontaneously regressein both treated mice and in controls — and in a few cases spontaneously regressein controls — and in a few cases spontaneously regressein a few cases spontaneously regressed.

Specifically, TheraT ® has proven to be safe in animals as well as capable of eliciting uniquely potent antigen - specific CD8 + cytotoxic T cell responses and strong tumor control in mice.

The decreased tumor size and enhanced tumor rejection in DGKζ - deficient mice indirectly suggests that enhanced Erk signaling may be superior to enhanced NF - κΒ activation in facilitating T cell activity against tumor, especially because DKO mice did not exhibit improved tumor control relative to DGKζ − / − mice.

In the study, Kwong's team successfully put their remote - control method through initial tests in mice with implanted tumors (so - called tumor phantoms, specially designed for certain experimentsIn the study, Kwong's team successfully put their remote - control method through initial tests in mice with implanted tumors (so - called tumor phantoms, specially designed for certain experimentsin mice with implanted tumors (so - called tumor phantoms, specially designed for certain experiments).

Collectively, these data indicate that DGKζ − / − mice exert improved control of orthotopically implanted KPC1242 tumors, compared with WT mice, in a manner that may result from changes in the number of intratumoral activated CD8 + T cells in DGKζ − / − mice.

Similarly, Cbl - b − / − mice and T cells lacking Cbl - b demonstrate improved control of s.c. - implanted tumors (23) and disseminated leukemia (32), along with decreased spontaneous tumor formation in ATM − / − mice (23) and UV B - treated mice (24).

Conditional expression of fascin led to decrease in mice survival and increase in tumor burden compared to control animals.

In the animal study, researchers divided a group of 52 mice with colon cancer tumors into three groups: a control group, a group fed the grape compounds and a group given sulindac, an anti-inflammatory drug that an earlier study showed decreased the incidence of tumors.

Sulforaphane, a putative anticarcinogen in broccoli, was provided orally to mice bearing androgen - insensitive human PC - 3 xenografts, and resulted in tumor volumes of 207 ± 35 and 90 ± 22 mm3 for the control and sulforaphane groups, respectively (22).

Additionally, tumor weights in the sulforaphane - treated mice were one - fourth those of the control tumors (P < 0.05).