Sentences with phrase «controlling cell proliferation»

The latest findings reported by researchers at La Jolla Institute for Allergy and Immunology illustrate just how important TET proteins are in controlling cell proliferation and cell fate.

«We were able to show that a significant number of these adenomas carry a mutation in a gene that is involved in controlling cell proliferation and differentiation,» Calebiro further explained.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

This is significant because IP4 controls cell proliferation, cellular metabolism and aspects of the immune system.

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

Not exact matches

But the researchers also found that the new molecule intervened directly in the growth of the cancer itself, inhibiting a protein that controls the division and proliferation of malignant cells.

Directly or indirectly, Holick points out, «the active form of vitamin D controls up to 200 different genes,» including ones responsible for cell proliferation, differentiation, and death.

The precise balance between the two compounds controls the transition from cell proliferation to differentiation.

«In normal conditions, the microenvironment is able to control the proliferation, differentiation and migration of the hematopoietic stem cell.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

The laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing ceCell Division & Cancer Group, working alongside Isabel Fariñas» team from the University of Valencia, shows, in a study published today in the journal Nature Communications, how in mice the elimination of the Cdh1 protein — a sub-unit of the APC / C complex, involved in the control of cell division — prevents cellular proliferation of rapidly dividing cecell division — prevents cellular proliferation of rapidly dividing cells.

In the case of planarians, the gene egr - 4 seems to perform an early control of cell proliferation as a response to amputation, and be involved later in the early differentiation of brain during regeneration.

University of California, Berkeley researchers have now found a promising new drug target within that pathway that is appealing, in part, because it appears to control production of only a few percent of the body's many proteins, those critical to regulating the growth and proliferation of cells.

It exerts this control by regulating cell proliferation and transformation into specific organ cell types.

To understand how the HIPPO pathway controls Schwann cell proliferation and myelination, the researchers used genome - wide screens.

The Hippo pathway not only defines final tissue size by controlling developmental growth, but is also key to specifying stem cell identity and proliferation, to regeneration and tissue repair, as well as numerous cell fate decisions.

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

LA JOLLA, CA — A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells.

They are broadly expressed in excitable and non-excitable cells, and have in turn been implicated in a large spectrum of physiopathological processes, ranging from the regulation of neuronal excitability, respiratory and cardiac function to the control of cell volume, hormone secretion and cell proliferation.

Jürgen Knoblich Institute of Molecular Biotechnology Asymmetric cell division and proliferation control in Drosophila [email protected] [phone]

GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.

Nelson and his team hope to understand the proliferation control mechanisms axolotls posses to better understand wound healing and cell growth in humans.

Initial studies demonstrated that ligation of 4 - 1BB on T cells could deliver costimulatory signals resulting in either increased proliferation or enhanced cytokine secretion and also control clonal expansion and differentiation of effector and memory T cells.

Runaway cell proliferation is driven by accelerators, or oncogenes, that are stuck on go — in collusion with broken brakes, or tumor suppressors, that can't control a tumor's pedal - to - the - metal growth.

Proto - oncogenes consist of a group of genes / proteins that, when expressed, normally encourage cell survival, growth and proliferation, while tumor suppressors perform the opposite task, keeping cells from dividing out of control.

Three leukemias that affect as many as 100,000 people in the United States are all caused by acquired mutations that alter a specific enzyme controlling blood cell proliferation, according to new...

By contrast, no significant changes in cell proliferation were seen following transient transfection with control 4E - BP1 siRNA.

The origins of many of these and other genes specific to animal processes such as cell adhesion, and social control of cell proliferation, death and differentiation can be traced to genomic events (gene birth, subfamily expansions, intron gain / loss, and so on) that occurred in the lineage that led to the metazoan ancestor, after animals diverged from their unicellular «cousins».

The authors first stably transduced freshly derived multipotent early passage hDPSCs with a PDGF - BB expression vector, generating cells that displayed heightened proliferation when compared to control hDPSCs.

MAP3K8 controls cancer cell proliferation and migration by regulating key players in G1 / S transition and adhesion dynamics.

Conversely, JAK inhibitors did not affect MAP kinase - dependent proliferation of control autonomous cells transfected with an activated mutant of M - RAS.

We want to understand how neural stem cell proliferation is tightly controlled, both spatially and temporally, to allow for the efficient formation of the highly organized neocortex.

Because of the rarity of bRG cells rodent models, the mechanisms controlling proliferation and self - renewal of these neural stem cells remain largely unexplored.

Inhibition of cell proliferation (B) of MCF7, MCF7 / HER2, or BT474 cells treated for 6 days with F3 - IgG, trastuzumab, or isotype control antibody.

Wnt / b - catenin / Tcf1 pathway controls mouse embryonic stem cell cycle progression and proliferation by regulating the Ink4 / Arf locus.

usage of model organisms to understand and exploit the mechanisms controlling stem and precursor cell generation, maintenance, activation, recruitment, proliferation, homing and differentiation,

Balb / c splenocytes were used as third - party responder cells assuming that these would induce the same degree of T cell proliferation in tolerant and control animals.

To assess the ability of F3 - IgG to inhibit the proliferation of HER2 - overexpressing breast carcinoma cells, we measured the proliferation of BT474, MCF7 / HER2 and MCF7 breast cancer cell lines in the presence of trastuzumab, F3 - IgG, or an isotype - matched control antibody.

The use of embryonic stem cells as therapeutics requires firm understanding of the mechanisms that control their proliferation and differentiation.

Surprisingly, there was no difference between our tolerant and control animals in the degree of T cell proliferation (data not shown).

Barnett JB, Dao MC, Hamer DH, et al: Effect of Zinc Supplementation on Serum Zinc Concentration and T Cell Proliferation in Nursing Home Elderly: A Randomized, Double - Blind, Placebo - Controlled Trial.

The proliferation rates of the cancer in the flax - eaters were only half that of the controls, confirming the test - tube studies done on prostate cancer cells suggesting that flax can indeed slow prostate tumor growth.

This protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self - destruction of cells (apoptosis).

Like the rest of its cruciferous family, the Brussels sprout contains high levels of sulforaphane, a phytochemical with high antioxidant activity that has been shown to regulate genes that control proliferation of cancer cells.