Sentences with phrase «controlling cell survival»

The researchers found that Takinib inhibits an enzyme called TAK - 1, which serves as a switch controlling cell survival in the TNF - alpha signaling process.

SKIP is an essential protein that controls cell survival and stress resistance.

Not exact matches

While study results indicated that combining capsaicin with the chemicals «might promote cancer cell survival,» the report clearly stated that the control group of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the study repeatedly cited other research studies in which the anti-cancer properties of capsaicin were solidly demonstrated.

The idea to specifically study this group of patients was based on groundbreaking research Garon published in the New England Journal of Medicine last year, which found that among patients who received pembrolizumab, those with PD - L1 expression on at least 50 percent of their cancer cells showed the longest survival and disease control.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

A multicenter team of researchers reports that a full genomic analysis of tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.

In a paper published in PLOS Genetics, QUT scientists Professor Sagadevan Mundree, Dr Brett Williams and their fellow researchers have proved sugar manipulation and the controlled sacrifice of cells are keys to the native grass's survival.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

In animal models, the modified T cells greatly reduced the tumor burden and prolonged overall survival: All mice that received the modified T cells were alive 44 days after treatment versus 29 percent and 17 percent of the study's two control groups.

Cancer tumours manipulate a natural cell process to promote their survival suggesting that controlling this mechanism could stop progress of the disease, according to new research led by the University of Oxford.

These factors are proteins that encourage cell growth, plasticity and survival, and therefore play an essential role in controlling neuronal function.

«Prostate cancer cells grow with malfunction of cholesterol control in cells: Shutting down this source at the root cause could improve cancer survival.»

Injecting the TRAIL - expressing stem cells into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with animals receiving unaltered stem cells or control injections.

HIPK2 - Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death

The tumors grew rapidly in the control experiments (the median time for tumor - free survival was one week) and any differences in tumor - free survival for the controls and the mice injected with cells expressing mutated PREX2 were not statistically significant (Horrigan et al., 2017).

Our work aims to investigate mechanistically the molecular processes through which dysregulation of factors controlling oxidative stress impairs RPE and photoreceptor cell metabolism and their survival in AMD.

GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.

As a control, irradiation of wild - type mice resulted in 100 % mortality after a period of 9 months after irradiation, when the mice were 11 months old (Fig. 3 ⇓ shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.

We have observed significantly better graft and patient survival in stem cell group vs. controls with additional benefits of minimization of immunosuppression.

We are identifying and characterizing the signaling molecules that control the interphase between cell survival and death cascades.

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

We have recently shown that signaling by BMP, once thought to maintain cell survival, helps to control epithelial cell shape and organization in the developing Drosophila wing.

Data from the laboratory shows that signals from these molecules through their receptors control the activities and long - term survival of T cells, as well as affecting the activities of other cell types including dendritic cells, macrophages, and epithelial cells.

Proto - oncogenes consist of a group of genes / proteins that, when expressed, normally encourage cell survival, growth and proliferation, while tumor suppressors perform the opposite task, keeping cells from dividing out of control.

(B) Survival of gp33 and NP396 CD8 T cell — immunized mice with LCMV infection following 30 d rest period compared with control mice.

In tumour cells, the signals controlling cell growth and survival are dysfunctional, thus enabling the cells to grow in an uncontrolled manner.

Here we controlled for some of the features that differed among the earlier studies, and analyzed both the survival and expansion of naive CD4 + T cells transferred into MHC syngeneic, allogeneic, or MHC negative environments.

(B) Survival of mice after intracardiac injection of 1833 (1 × 105) breast cancer cells and treatment with either dimethyl sulfoxide (DMSO) control or the allosteric ABL inhibitor GNF5.

To directly examine whether ABL kinases play a role in regulating the colonization and survival of breast cancer cells in the bone microenvironment, we injected control or ABL1 / ABL2 knockdown breast cancer cells directly into the tibia of immunodeficient mice.

(B) Survival of mice after intracardiac injection of 1833 (1 × 105) breast cancer cells transduced with control shRNA (Scr) or shRNAs against ABL1 and ABL2 (shAA); n = 10 mice per group.

The goal is to test if targeting the vitamin D receptor will unlock the potential of immunotherapies to kill pancreatic cancer tumor cells and potentially establish a therapeutic combination for controlling advanced pancreatic cancer, extending patient survival, and reducing patient side effects.

Mice treated with this cell line had an 83 percent survival rate, compared to 33 percent for controls.

«Our data show that control of survival of lung adenocarcinoma cells by Notch1 requires a functional p53,» they wrote.

Interestingly, the LARP7 - overexpressing cells formed significantly fewer colonies than those harboring the control vector (Figure 7D), suggest that re-expression of LARP7 impairs survival of these metastatic breast cancer cells.