Not exact matches
The current view proposes that
stem cell differentiation is
controlled by their local environment, the so - called niche.
Varghese and her team showed that they could
control the
differentiation of human pluripotent
stem cells into functional osteoblasts — bone - building
cells — simply by adding the molecule adenosine to their growth medium.
Since Yamanaka's breakthrough, dozens of groups have reported other ways of reprogramming
cells as well as techniques to
control differentiation of
stem cells into neurons, cardiovascular
cells, and other tissues of interest for regenerative medicine.
There is no question that ability to generate glucose - responsive, human beta
cells through
controlled differentiation of
stem cells will accelerate the development of new therapeutics.
«In normal conditions, the microenvironment is able to
control the proliferation,
differentiation and migration of the hematopoietic
stem cell.
In CRC 873, funded by the German Research Foundation, medical and biological scientists investigate the basic regulatory mechanisms that
control the self - renewal and
differentiation of
stem cells.
Researchers in Japan have shown that modified gold nanoparticles can be used to
control the
differentiation of
stem cells into bone.
However, in developing brain
cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished
stem cell differentiation into brain
cells and increased
cell suicide, a carefully
controlled process known as apoptosis.
«A better way to grow bone
cells: New method allows for more
control in the
differentiation of
stem cells into bone
cells.»
Researchers at the Institute for
Stem Cell Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of human pluripotent stem cells, and thus produce different populations of motor neurons from these cells in only 14 d
Stem Cell Therapy and Exploration of Monogenic Diseases (I -
Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of human pluripotent stem cells, and thus produce different populations of motor neurons from these cells in only 14 d
Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better
control the
differentiation of human pluripotent
stem cells, and thus produce different populations of motor neurons from these cells in only 14 d
stem cells, and thus produce different populations of motor neurons from these
cells in only 14 days.
The
differentiation of
stem cells is largely
controlled by external cues, including morphogenic growth factors, in the three - dimensional environment that surrounds the
cells.
In turn, the niche
cells control the production and also the
differentiation of the blood
stem cells.
His work has focused on discovering and characterizing novel small molecules that can
control various
cell fates and functions, including
stem cell maintenance, activation,
differentiation and reprogramming in various developmental stages and tissues.
Our work focuses on discovering and characterizing novel small molecules that can
control cell fate and function in numerous
cell types, including
stem cell maintenance, activation,
differentiation, and reprogramming in various developmental stages and tissues.
Title: Interplay between FGF2 and BMP
controls the self - renewal, dormancy and
differentiation of rat neural
stem cells Authors: Sun Y, Hu J, Zhou L, Pollard SM, and Smith A Date: June 2011 Publication Details: J
Cell Sci, Jun 1 2011:124 (11); 1867 - 1877
Professor Kyurkchiev's group is currently developing a project on the
controlled differentiation of human induced pluripotent
stem cells into hematopoietic
stem cells and lymphoid
cells.
He has been interested in
differentiation and growth
control throughout his career and is an expert on hematopoietic
stem cells, macrophage
differentiation, hematopoietic and Maf family transcription factors.
Embryonic
stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
stem cells, Adult
stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
stem cells, Reprogramming to pluripotency and lineage conversion, Directed
differentiation, Germ
cells, Genetic and epigenetic mechanisms,
Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
Stem cells in development,
Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
Stem cell niche, Cancer
stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
stem cells, Disease modeling and drug screening,
Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics,
Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Jou
Stem cell products, manufacturing, and quality
control, Ethical, legal, and social issues Read Journal
Research Interests: Molecular
control of
cell fate from stemness to differentiated skeletal and neuronal
cell types; SOX transcription factors; skeletal malformation and degeneration diseases; intellectual disability and autism spectrum disorders; mouse genetic models; human pluripotent
stem cell differentiation models in vitro
The fellow will drive a new project focusing on molecular mechanisms
controlling the identity, self - renewal, and
differentiation potential of skeletal
stem cells.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms
controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular
differentiation, human embryonic
stem cells, stromal
cells, haematopoietic
stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
usage of model organisms to understand and exploit the mechanisms
controlling stem and precursor
cell generation, maintenance, activation, recruitment, proliferation, homing and
differentiation,
The use of embryonic
stem cells as therapeutics requires firm understanding of the mechanisms that
control their proliferation and
differentiation.