For example, our discovery of HORMAD1 (Fig 2) and HORMAD2, two proteins that preferentially associate with unpaired / unsynapsed meiotic chromosome cores / axes, allowed us to address how progression in meiosis is coordinated with crossover
formation, and how meiotic checkpoints / quality
control ensure that only those meiocytes progress in meiosis that correctly paired and
synapsed their homologous chromosomes.