Sentences with phrase «controls cell reprogramming»

Aulicino F, Theka I, Ombrato L, * Lluis F, * Cosma MP (2014) Temporal perturbation of the Wnt signalling pathway controls cell reprogramming via Tcf1 activity.

Not exact matches

Nanog and Sox2 are among the enzymes used by researchers to generate iPSCs, therefore ZFP217 may represent another tool needed to achieve tight control over cell reprogramming.

Like a cruel form of mind control, some cancerous tumours can reprogram some immune cells to «block» other immune cells from attacking, leaving the tumour free to grow.

The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.

The new study, published in Nature Communications, also presents significant advancements in cellular reprogramming technology, which will allow scientists to efficiently scale up pancreatic cell production and manufacture trillions of the target cells in a step-wise, controlled manner.

Since Yamanaka's breakthrough, dozens of groups have reported other ways of reprogramming cells as well as techniques to control differentiation of stem cells into neurons, cardiovascular cells, and other tissues of interest for regenerative medicine.

When they performed the reprogramming experiment, they observed Induction of endogenous Nanog and Esrrb was substantially delayed and suppressed in Krr1 - depleted cells compared to control cells.

But in Turritopsis, the reprogramming of one cell into another kind of cell «is part of a controlled pathway.»

«Stem cell reprogramming factor controls change in cellular energy generation: Research reveals role for KLF4 protein in instructing cells to undergo metabolic changes while acquiring stem cell characteristics.»

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

Figuring that out could help researchers better understand what happens as cells are reprogrammed and may also provide new clues to the molecular signals that control the difference between pluripotency and totipotency.

His work has focused on discovering and characterizing novel small molecules that can control various cell fates and functions, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.

Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types, including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.

The researchers identified 24 potential reprogramming factors — proteins that control whether other genes in the cell are turned on or off.

Understanding these pathways, and the identification of the key proteins that control the ability of cancer cells to reprogram their metabolism through biochemical, and epigenetic or genetic alterations that make them resistant to therapies, is of paramount importance for the design of more targeted and therefore less toxic therapies.

We hypothesize that upon retinal neuronal damage MG or RPE cells undergo defined and controlled changes in cellular and molecular phenotype towards a cell with progenitor properties — this process that we are studying we call regenerative reprogramming.

Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal

The findings reported in Nature Genetics indicate that genome architecture has important informational value for controlling gene expression during cell reprogramming, and is thus required for the specialized functions of a cell.

Furthermore, we demonstrated cell - fusion mediated reprogramming as an efficient therapy for Parkinson's disease, and as mechanism to control liver regeneration, an organ with high regenerative capacity in mammals (Altarche - Xifro et al eBiomedicine 2016; Pedone et al..

We are also investigating the mechanisms controlling cell - to - cell fusion, and how ploidy is controlled in reprogrammed hybrids.