Sentences with phrase «controls synaptic function»

Not exact matches

In this publication, under the title of «Membrane - Derived Phospholipids Control Synaptic Neurotransmission and Plasticity», the Cadiz scientists have reflected the work of years that has led them to identify a molecule, Lysophosphatidic acid (LPA), as a possible element implicated in the link between the metabolic state of an organism and its cerebral function.

This regulation is spectacularly apparent in the exquisite speed and precision of synaptic exocytosis, where synaptotagmin (the calcium - ion sensor for fusion) cooperates with complexin (the clamp activator) to control the precisely timed release of neurotransmitters that initiates synaptic transmission and underlies brain function.

We also conduct electrophysiological, biochemical, imaging, antd behavioral studies with various knockout and transgenic mice to determine how precise genetic manipulations that either activate or abolish specific translational control mechanisms alter synaptic function and behavior.

We will explore the function of these genes in controlling synaptic homeostasis, develop novel imaging approaches to visualize homeostatic changes in real time, and systematically screen genes implicated in aging and longevity for roles in homeostatic plasticity.

Homeostatic control of synaptic function has been demonstrated in diverse organisms, including flies, rodents, and humans, yet the genes and molecular mechanisms governing these processes remain unclear.

In order to analyze the function of individual proteins in neuronal circuits or synaptic remodeling, researchers combine the Cre and FLP recombinases to control both knockout of a target gene and expression of a separate gene.

He also studies how dysregulated translational control contributes to altered synaptic function and aberrant behaviors in developmental brain disorders and neurodegenerative disease.