Sentences with phrase «conventional drugs in»

Not exact matches

Her doctor suggested Erbitux — a proven cancer drug that targets cancer cells exclusively, unlike conventional chemotherapies that more crudely kill all fast - growing cells in the body — and Aucoin went to a clinic to begin treatment.

The reflections of the French Catholic writer François Mauriac, who succeeded in leading a conventional family life despite what he experienced as the powerful lure of alcohol, drugs, and homosexuality, demonstrate the gap between the austere piety of the religious individual and the tactful lifestyle that Tóibín detects in James:

In fact, most conventional wisdom suggests that legalization actually makes illegal drug cartels less powerful because more legitimate businesses will be able to enter the market.

«If you give patients immune cells to eradicate any remaining cancer cells that might be present,» he says, «those immune cells would not be prevented from doing their job by ongoing immune suppression drugs that are being used in patients treated with conventional transplant approaches.»

Whereas most conventional scientists focus on a single system or disease, Butte earned tenure recently with a dossier of advances in diabetes, obesity, and transplant rejection, and the discovery of new drugs for lung cancer and other diseases.

In recent years, Merlin's lab and others have explored how to deliver conventional drugs via nanotechnology.

BPTES has been used in animal models for a variety of cancers but has not substantially reduced tumor sizes, probably because the drug concentration in tumor tissue is not high enough when using conventional drug formulation methods, say the scientists.

These are aimed specifically at pathways involved in either the initiation and progression of cancer or its resistance to conventional drugs.

«Conventional drugs targeting the enzymes encoded by MMP genes have not been successful in the clinic due to adverse side effects,» said Rahme.

Conventional drug discovery remains a hit - and - miss affair and Hunter believes the 50 percent failure rates seen for experimental compounds in mid - and late - stage clinical trials due to lack of efficacy is unsustainable, forcing a shift to AI.

As reported in the journal Angewandte Chemie, this drug blocks key enzymes used in mycomembrane biosynthesis, significantly increasing the effectiveness of conventional antibiotics.

Convened in part by the White House Office of National Drug Control Policy, the meeting will bring together academics, government officials, industry experts, and patient advocates to discuss the use of naloxone both in and out of conventional medical settings.

The study by researchers at King's College Hospital and the University of Southampton suggests that adding nutraceuticals to chemotherapy cycles may improve the effectiveness of conventional drugs, particularly in hard to treat cancers, such as pancreatic cancer.

In addition, we found that lower doses of the conventional drug were needed, suggesting either that the compounds work together synergistically, or that the extract exerts a «supra - additive» effect.

While the 3D injectable scaffold is being tested in mice as a potential cancer vaccine, any combination of different antigens and drugs could be loaded into the scaffold, meaning it could also be used to treat infectious diseases that may be resistant to conventional treatments.

«We expect that the proposed treatment will be especially effective in advanced stages of ovarian cancers, where there are many cancer stem cells in the tumors that resist conventional drug treatment,» says Minko.

Writing in a linked Comment, Professor Philip Cowen, MRC Clinical Scientist, University of Oxford, Oxford, UK, says: «The key observation that might eventually justify the use of a drug like psilocybin in treatment - resistant depression is demonstration of sustained benefit in patients who previously have experienced years of symptoms despite conventional treatments, which makes longer - term outcomes particularly important.

In a provocative challenge to conventional wisdom, the report suggests that the U.S. government not focus on the F grades, several of which refer to worst - case scenarios like drug - resistant bioweapons or millions of casualties.

«About 15 to 20 percent of patients who start conventional treatment for drug - resistant TB don't finish, mostly because of the length, expense and discomfort associated with it,» says Emily Kendall, M.D., an instructor in the Department of Medicine at the Johns Hopkins University School of Medicine.

The court also noted that Prometheus's claims fell short because its invention — a method of monitoring thiopurine drugs in the blood — involved a «well - understood, routine, conventional activity previously engaged in by researchers in the field.»

These results are better than those in trials using conventional ADHD drugs, such as Ritalin and Adderall, says Daryl Efron at Murdoch Childrens Research Institute in Melbourne.

Many conventional hepatocyte cells that are transplanted to mice for in vivo testing last for only two or three days, but the drug and its various metabolites might take weeks to metabolize, so toxic effects might not be apparent in such testing.

Most conventional drugs function as inhibitors — they're just the right size and shape to jam themselves into some molecular cog in our cells.

In the bone marrow microenvironment, CLL cells are protected from spontaneous or drug - induced apoptosis, resulting in resistance to conventional chemotherapIn the bone marrow microenvironment, CLL cells are protected from spontaneous or drug - induced apoptosis, resulting in resistance to conventional chemotherapin resistance to conventional chemotherapy.

Repurposing refers to the reuse of conventional drugs with distinct indications for new applications in order to speed up drug development by capitalizing on previous knowledge and safety data.

These results will be correlated with the clinical and pathological characteristics of the patiens in order to determine if those patients which did not respond to conventional chemotherapeutical drugs have a higher de-regulation of metabolic reprogramming and / or autophagy.

Orders of magnitude more sensitive than conventional Raman microscopy, they allow mapping of 3D distributions of small molecules, such as metabolites and drugs, as well as tumor identification in tissues, which open many exciting new possibilities for biology and medicine.

We currently evaluate the therapeutic benefits as well as the toxicity of drug candidates in spheroids by means of conventional fluorescence microscopy as well as LSFM and many different biochemical and molecular biology - based assays (Ansari et al. 2013; Wenzel et al. 2014; Pampaloni & Stelzer 2010).

An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as starting points for design of novel therapeutic compounds.

12/5/2007 Protein Found That May Provide Relief from Neuropathic Pain Neuropathic pain is caused by injury to the peripheral nerves in diseases such as HIV / AIDS, shingles, and cancer or in repetitive motion disorders and trauma, and does not respond well to conventional pain - relieving drugs.

Carmot's vision is to become a leader in drug discovery by unlocking novel therapeutic target space not currently accessible to conventional small molecule technologies.

August 16, 2011 New drug aids gout patients not helped by standard treatments Pegloticase, a modified porcine enzyme, can produce significant and sustained clinical improvements in 2 out of 5 patients with chronic gout that is resistant to conventional therapies, researchers report in the August 17, 2011, issue of JAMA.

This Act became effective in 2011 and specifies that the benefit and harm of newly approved drugs must be assessed in comparison with conventional treatments.

MONDAY, November 7, 2011 (Health.com)-- A class of injectable drugs used to treat autoimmune disorders such as rheumatoid arthritis doesn't raise the risk of serious infection when compared with more conventional treatments, according to a new analysis in the Journal of the American Medical Association.

A 1984 study looked at the use of Fulvic / Humic acids in chronic bronchitis and found that these were as effective (or more so) than conventional drug therapies at alleviating symptoms.

Naturopathy has also been the subject of a fair amount of controversy over the years, with some researchers claiming that it was dangerous to believe in use of it as opposed to more «mainstream» or conventional pharmaceutical drugs.

A meta - analysis of literature related to the use of velvet antler products as an alternative to drugs provides credible evidence to support the claim that compounds in velvet antler may be significantly more effective than many conventional prescription and over-the-counter drugs for relief of the symptoms of osteoarthritis.

A conventional diabetes drug, when taken alongside traditional Chinese medicine herbs, was significantly more effective in treating type 2 diabetes.

While modern medicine continues to rely on the same illogical and poor symptomatic psoriasis drug treatment methods, over half of all psoriasis patients in America alone refuse conventional psoriasis medical treatment due to the high cost in addition to very poor outcomes.

Garlic was confirmed in reports back in the 1980's to be more active against human ringworm (a fungal infection) than conventional pharmaceutical drugs.

Conventional products in a drug store never live up to my standards.

The primary treatment for LUTS, BPH and CP in conventional medicine involves the use of alpha - adrenergic antagonist drugs (such as Flomax) and 5 - alpha - reductase inhibitor drugs.

In response, conventional medicine offers up drugs that in no way, shape or form treat the cause of the problem, and worse yet, can prematurely kill many of those who take theIn response, conventional medicine offers up drugs that in no way, shape or form treat the cause of the problem, and worse yet, can prematurely kill many of those who take thein no way, shape or form treat the cause of the problem, and worse yet, can prematurely kill many of those who take them.

The conventional approach is to block, antagonize, suppress and inhibit the immune system with drugs; whereas the Functional Medicine approach is to get a thorough history of the person's health, because everything in the body is connected, in order to find the root underlying cause of their symptoms — and of their autoimmune disease.

Consider the irony: some conventional physicians are prescribing estrogens to treat a presumed hormone deficiency in postmenopausal women, while others are prescribing drugs that block estrogen production in postmenopausal women.

In fact, most conventional treatments for type 2 diabetes utilize drugs that either raise insulin or lower blood sugar.

Many women going through intense hormonal fluctuations use bioidentical hormones as a gentle and natural alternative to the synthetic hormones found in conventional hormone replacement therapy (HRT) drugs, Premarin or Prempro.

Gastrointestinal diseases can be tricky to heal with conventional medicine because the gut flora is already in duress and drugs can further irritate the stomach's lining.

In conventional medicine, a condition must have progressed far enough to diagnose and treat with drugs or surgery, such as thyroid removal (which still doesn't help many patients).

Currently, conventional preventive medical approaches to inflammation are limited to the use of CRP to predict cardiovascular disease in high - risk subjects, and the prophylactic use of drugs like aspirin to inhibit the inflammatory cascade linked to thrombosis (uncontrolled blood clotting).