Sentences with phrase «conventional light microscope»
«We can use expansion pathology to push conventional light microscopes beyond their current limits, which could have important applications in diagnostic pathology,» said the study's co-lead author, Octavian Bucur, MD, PhD, of the Department of Pathology and Cancer Research Institute at BIDMC, who is also a Ludwig Cancer Center Research Investigator.
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While conventional tabletop microscopes shine light through the sample from above, the Shih lab's technology launches the light from the side of the slide, which is about one millimeter thick.
In 1873, German physicist Ernst Abbe deduced that conventional optical microscopes can not distinguish objects that are closer together than about 200 nanometres — roughly half the shortest wavelength of visible light.
A conventional microscope can not distinguish objects — say, molecules — that are packed within a space of about 200 nanometers because they all become flooded with light at the same time.