While a WFPB diet provides support for a prevotella bacteria gut population that does not
convert choline / carnitine into TMAOs, the issue of whether simply ingesting source of choline / carnitine and its effect on the gut bacteria population has NOT been adequately addressed.
Their argument was that our intestinal bacterial
convert choline to trimethylamine, which our livers then convert to trimethylamine oxide (TMAO), which causes atherosclerosis in mice, and thus, by extension, probably in humans.
Gut bacteria also can
convert choline into TMAO, that study showed.
Not exact matches
Eggs, beef, pork and fish are the primary sources of carnitine and
choline — compounds that are
converted by gut microbes into trimethylamine, which is then processed by the liver and released into the circulation as TMAO.
They are full of nutrients like
choline (lowers inflammation, helps
convert homocysteine — a molecule that can damage blood vessels), vitamin B12, lutein (an important carotenoid that may prevent age - related macular degeneration).
The
choline in eggs, like the carnitine in red meat, is
converted into a toxin called trimethylamine by bacteria existing in meat - eaters» guts.
Remember, dietary
choline is
converted in the gut into trimethylamine.
DMAE crosses the blood brain barrier, and is
converted to
choline, a precursor to acetylcholine, the memory neurotransmitter.
In addition,
choline is
converted to betaine in your body, which assists in the conversion of homocysteine to methionine, thus preventing homocysteine levels from becoming elevated.
However, serum TMAO will only be formed in significant quantities if the bacteria that
convert exogenous substances to TMA are present, and emerging evidence suggests that it is microbial dysbiosis, and not dietary
choline, that is the problem (16, 17).
And you want to
convert that back to NAD + And the amino acids that do that, are your
choline, lysine, and glycine.
DMAE is
converted to
choline in the liver.
Choline can be
converted by the body into acetylcholine, which is an essential neurotransmitter.
Still, some DMAE crosses into the brain, and there it can also be
converted to
choline which can then be used to synthesize the neurotransmitter, acetylcholine.
Does this pose a risk insofar as
choline is
converted into betaine?
``... more than 100 grams [4 ounces in one week] of carnitine, lecithin, or
choline, or any combination of them, changed the way your gut bacteria metabolized those themselves to produce two things, butyl butane, which in the long term causes kidney disease and kidney failure, and TMA which you absorb and then the liver
converts to TMAO which is a greater risk for inflammation and all things that go along with inflammation, heart disease, stroke, memory loss, impotence, decaying orgasm quality, wrinkling, cancer, and brain rot.»