Loss - of - function mutations can disrupt
both copies of a given gene in humans and phenotypic analysis of such «human knockouts» can provide insight into gene function.
Not exact matches
To coax the apples to create these particular anti-browning RNA molecules, the scientists
gave the apple extra
copies of the browning
gene that were tweaked to set off the plant's interference mechanism.
Chen and his colleagues, postdocs Xiongyi Huang, Jennifer Kan, and graduate student Ruijie Zhang, did this by
giving the bacteria a
copy of a
gene that encodes an enzyme called cytochrome P450.
Giving multiple
copies of the
gene to addicts would prevent them...
In a now - famous report, petunias turned white when
given extra
copies of coloring
genes.
Having only one variant
copy of the
gene gives people the appearance
of looking about one year older on average, the team
of Dutch and British researchers concluded.
Doctors
gave the patients stem cells containing
copies of a properly functioning
gene for the enzyme; the babies» immune systems were then able to reconstitute themselves.
A large body
of research has reported that Nanog is allelically regulated — that is, only one
copy of the
gene is expressed at any
given time — and fluctuations in its expression are responsible for the differences seen in individual embryonic stem (ES) cells» predilection to differentiate into more specialized cells.
Lead researchers Eric Reiman and Pierre Tariot
of the Banner Alzheimer's Institute in Phoenix plan to
give a yet - to - be identified anti-amyloid drug, or placebo, to 650 people who carry two
copies of the APOE4
gene — a genetic double whammy that confers a 10-fold increased risk
of developing Alzheimer's late in life.
They also
gave the cells a correct
copy of the A1At
gene so that the cell's DNA repair machinery would use it as a template to heal the break.
The study for the first time estimates the minimum number
of locations in the human genome — 250 to 300 — where
gene copy number variation (CNV) can
give rise to autism spectrum disorder (ASD).
In this way, the mutation is somewhat similar to sickle cell anemia in humans, where having one
copy of a mutated
gene gives one an immunity to malaria, while two
copies causes a painful, life - threatening illness.
«If a patient has a mutation in a specific
gene, it would be a way
of giving them a normal
copy to try to correct that
gene.