http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ When I did a high carb low fat diet, my fasting blood sugar kept rising, and when you consider that some people who have fewer
copies of amylase genes, may actually do better on a high fat low carb diet.
I agree it's significant that dogs have between four and 30
copies of the amylase gene, and this wide range would indicate that some dogs are much less able to handle starch than others.
Not exact matches
While chimps have only two
copies of the salivary
amylase gene (one on each
of the relevant chromosome pair), humans have an average
of six, with some people having as many as 15 (Nature Genetics, vol 39, p 1256).
In a new study published in The Quarterly Review
of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form
of starch, was critical for the accelerated expansion
of the human brain over the last million years, and coevolved both with
copy number variation
of the salivary
amylase genes and controlled fire use for cooking.
Both the hunter - gatherers as well as the early farmers displayed high
copy numbers
of amylase genes in their genomes, suggesting that both populations had already adapted to a starch - rich diet.
In this work we use high - resolution analysis
of copy number, and analysis
of segregation in trios, to define new, independent allelic series
of amylase CNVs in sub-Saharan Africans, including a series
of higher - order expansions
of a unit consisting
of one
copy each
of AMY1, AMY2A and AMY2B.
Evidence for multiple
copies of the salivary
amylase gene in high starch eating Asians, and a gene variant that is important for breaking down fats in plant foods in Europeans and Middle Easterners may reflect an adaption to agriculture (Hancock et al, 2010).
He also mentions genetic studies that claim that humans have more
copies of the genes for
amylase than other great apes strongly suggesting that humans are designed to digest starch.
The researchers first found that dogs had between four and 30
copies of a gene that codes for
amylase while wolves had only two
copies.
Dogs had four to 30
copies of the gene for
amylase, a protein that starts the breakdown
of starch in the intestine.