Sentences with phrase «copies of the new gene»

Its sperm and egg cells will thus bear two copies of the new gene, which radically increases the odds that its offspring will inherit it.

Not exact matches

Lacking money to outfit the new lab, Wang and Xin bought used equipment: a single channel DNA sequencer (bought and barely touched by a Harvard Medical School researcher); second - hand centrifuges and pipettes; a reconditioned CytoScan HD system that detects variations in the number of copies of a gene.

These highly repeated bits of DNA are capable of expressing and inserting new copies of themselves back into the genome — hence the sobriquet «jumping genes.»

In this cycle, new gene copies often arise by gene duplication, with the copies persisting or adapting into new roles within the genome for varying lengths of time, or dying off and being lost randomly.

«Analyzing copies of genes offers new treatment possibilities for ovarian cancer.»

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics — an alteration that results in the loss or gain in a copy of a gene.

The new method has been tested in greenhouse trials to show that the more copies of the gene, the greater the resistance to soybean cyst nematode.

Although the researchers suspected that having more copies of the gene sequence might confer a greater degree of resistance, they had no way of testing their suspicions before the new assay was developed.

The number of copies of the resistance gene varies among cultivars; a new method, developed by University of Illinois researchers, is able to efficiently quantify this variation for the first time.

New genome - sequencing research suggests white European people with two copies of variant forms of MC1R, a gene linked to pale skin and red hair, have faces that appear up to two years older than those who are the same age but don't have both copies.

A strong, male - biased mutation spectrum was also measured, wherein three - quarters of mutations occurred in sperm thorough spermatogenesis, as well as new structural alterations, such as changes in gene conversion and copy number.

By studying rare «copy number variations,» which are individual errant insertions or deletions of DNA segments (each of which occur in less than one percent of the population), researchers discovered a new cluster of genes that are affected in some autistic individuals as well as a number of mutations that were present in autistic children but not their parents.

In the new study involving mice, published in the journal Molecular Neurodegeneration, the injection of zinc finger repressed the mutant copies of the gene for at least six months.

The new study suggests that even rare mutations that disable both copies of a gene, which scientists thought would be associated with diseases, aren't necessarily a problem.

They can do this in various ways, but the new pictures are about one way in particular: events occurring after the attachment of the machinery to an RNA message (mRNA) copied from a gene.

For the new mouse model, the researchers exposed adolescent mice with at least one copy of a variant of the BDNF gene, which has been associated with anorexia and anxiety in mice and humans, to social stress and caloric restriction.

In another paper in the same issue, a team led by molecular biologist Ronald Plasterk, now at the Hubrecht Laboratory in Utrecht, the Netherlands, reports an intriguing twist: The same genes appear to be responsible for both RNAi and another gene - silencing mechanism known as cosuppression, in which adding extra copies of a gene cause both the new and the existing copies of that gene to be shut down.

In the new study, Deisseroth's team used mice that lack both copies of CNTNAP2, a gene linked to autism.

Breast cancer patients with a mutation in both copies of the NQO1 gene have a 20 % lower survival rate 5 years after treatment than do patients without the mutation, according to a new study of more than 2000 Finnish women.

To stop hepatitis C, any effective drug also had to incorporate itself into the virus's genetic code, where it would need to halt the virus's ability to make new copies of its genes and thus to make new virus.

Mice carrying a mutated copy of the gene have 10-fold fewer neurons and other brain abnormalities, a new study suggests.

While the cell is in the process of copying its genetic material, the new DNA would then replace a nearly identical existing gene segment in the cell, changing it slightly.

As reported in the new study, the researchers were able to postpone the onset of hearing loss and associated hair cell degeneration by about a month, providing enough time to inject normal copies of the Clarin - 1 gene into the ear before the onset of hearing loss to see if the treatment was effective.

It can help organisms take advantage of new opportunities: With extra copies around, some genes keep doing their old job while others are repurposed for some brave new world.

Both of the new studies found that copy number events involving either duplication or deletion of the 25 to 30 chromosome - 16 genes — several of which are known to play a role in the developing brain — appear to cause autism.

About the same time, scientists at Cold Spring Harbor Laboratory in Long Island, N.Y., focusing on families with one autistic child, reported that an estimated 10 to 30 percent of all reported cases of autism may be caused by new (or spontaneous) mutations in the number of copies of genes in children (that were not found in either parent).

Simply replicating a piece of a particular gene — from one copy in mice to more than 200 in humans — may have prompted some of the changes in the brain that define us as human, according to a new study.

While we had previously found an effective treatment for those with the «celtic gene» this new combination treatment has the potential to help roughly half of those with cystic fibrosis, those who have two copies the F508DEL mutation.

According to Dr. Wong, «This combined strategy provides us with a new tool for reliable molecular analysis of any genes containing multiple copies of highly homologous sequences and should improve the positive finding rate for patients with Lynch syndrome if the PMS2 gene is suspected to be defective.

Since DNA moves between individuals, a new generation will not be stuck with just a copy of its parental genes.

By inserting the gene for a new trait alongside genes for a DNA - cutting enzyme and an RNA guide, scientists can prompt a cell to slice out copies of the original, wild - type gene from its chromosomes and use the inserted gene as a template for repair.

«The copied genes show us which bacteria species are in the sample and tell us new information about the diversity of arsenate - reducing microorganisms.»

In a previous study, Shaw, an associate professor in Salk's Molecular and Cell Biology Laboratory and researcher in the Institute's new Helmsley Center for Genomic Medicine, demonstrated that cells lacking a normal copy of the LKB1 gene fail to activate AMPK in response to low energy levels.

«We found a new gene, a perfect copy of another gene,» said Parker.

Using DECoN (which stands for Detection of Exon Copy Number variants), the researchers took advantage of the high density of sequencing data available in new gene panels to accurately detect deletions or duplications of exons.

In the new study, a team led by Harvard University's George Church — one of the pioneers of the CRISPR technique — used gene editing to remove all the copies of porcine endogenous retroviruses (or PERVs) from their pig cells» DNA.

When a new copy of their DNA gets inserted into our genome, it can disrupt an essential gene.

And when the microbe divided in two, it made new copies of the frog genes along with its own.

Developing novel tools to quantify gene expression in single cells As it has become increasingly apparent that gene expression in individual cells deviates significantly from the average behavior of cell populations, new methods that provide accurate integer counts of mRNA copy numbers in individual cells are needed.

For 1,317 distinct genes, both copies were found to have deleterious mutations in at least one individual, resulting in «human knockouts» for a remarkable number of new genes for whom human knockouts have never been reported.

By characterizing the role of gene mutations and copy number variations in a number of complement associated disorders, including kidney diseases, such as HUS (Hemolytic Uremic Syndrome), DDD (Dense Deposit Disease) or AMD (Age Related Macular Degeneration) the group has identified new disease subtypes of this severe kidney diseases.

Team finds that some cells activate only one of their two gene copies during development, altering protein yields and raising new questions...