Not exact matches
While
sequences capture most of the clinical
genomics attention, scientists have learned over the past decade that something called
copy number variations (CNVs) also play a role.
Another distinctive genetic feature of mucosal melanoma is its high rate of
copy number and structural variants, demonstrated both by array - based comparative
genomic hybridization and whole - genome
sequencing.
Wang Z, Andrews P, Kendall J, Ma B, Hakker I, Rodgers L, Ronemus M, Wigler M, Levy D. SMASH, a fragmentation and
sequencing method for
genomic copy number analysis.
Many patients suffering from Rare Disease harbour
genomic variants (
sequence variants or
copy number variants) that by disrupting normal gene expression lead to disease.
This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of
genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA
copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of
sequence variation.
However, being a complex multistep process, cancer cytogenetics are broadened to «cytogenomics,» with complementary resources on: general databases (nucleic acid and protein
sequences databases; cartography browsers: GenBank, RefSeq, UCSC, Ensembl, UniProtKB, and Entrez Gene), cancer
genomic portals associated with recent international integrated programs, such as TCGA or ICGC, other fusion genes databases, array CGH databases,
copy number variation databases, and mutation databases.