Not exact matches
In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists
led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off»
pain signals in the spinal
cord to provide relief from chronic
pain.
Injuries of the spinal
cord can
lead to extreme
pain (e.g. pressure in the head, neck or back), the loss of sensation (e.g. in fingers or feet), the loss of control over different parts of the body, an abnormal sense of balance and many other symptoms.
In a major breakthrough, a team
led by researchers at the Salk Institute and Harvard Medical School have identified an important neural mechanism in the spinal
cord that appears
to be capable of sending erroneous
pain signals
to the brain.
Implantable spinal
cord stimulators and peripheral nerve stimulators designed
to interrupt nerve
pain impulses were developed more than 30 years ago, but the devices work by interacting with sensory nerve cells,
leading to numbness, tingling and other side effects.
Surgery
to remove disc material compressing the spinal
cord leads to recovery of function in almost all dachshunds that still have
pain sensation in their pelvic limbs but the outcome is much more variable when
pain sensation has already been lost.
Possibly, trauma may bring fracture of the bridge created in the development of spondylosis, which crack may spread
to the arch and body, thus pinching the spinal
cord,
leading to pain and possibly neuromuscular dysfunction and loss of urinary and bowel control.
Spinal
cord injuries can be very debilitating and can
lead to secondary medical problems including infection, muscle spasms, loss of bodily functions, and over-sensitivity
to temperature or
pain in specific body parts.
Symptoms include
pain that occurs with or without movement, muscle spasms, and, without proper treatment, may
lead to more severe spinal
cord and nerve injuries.