«We don't have a lot of medications for
the core symptoms of autism — arguably we have none,» says Thomas R. Insel, director of the National Institute of Mental Health.
At Caltech, developmental neurobiologist Paul Patterson found he could induce
the core symptoms of autism and schizophrenia in mice by giving their mothers the flu during pregnancy, or by arousing their immune systems in utero with an injection of foreign RNA.
«Right now we have no medications treating
the core symptoms of autism.
There is no Food and Drug Administration - approved medical treatment for
the core symptoms of autism spectrum disorder, a lifelong neurodevelopmental condition whose hallmarks are deficits in social relatedness, repetitive thoughts and behaviors and, often, intellectual disability.
«We have discovered a small molecule compound that shows a profound and prolonged effect on autism - like social deficits without obvious side effects, while many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for
this core symptom of autism,» said Zhen Yan, PhD, professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB, and senior author on the paper.
Not exact matches
Problems with communication, specifically non-verbal cognitive ability, are a strong predictor
of externalising behaviour problems.3 Children with ASD exhibit more severe internalising and externalising behaviours than non-ASD children, as well as a high prevalence
of aggressive behaviour.3 These behavioural challenges can often cause caregivers more distress and mental health problems than the
core ASD
symptoms.4, 5 Increased child behaviour problems and parental (especially maternal) psychological distress compared with children without
autism is established early in life — by the time that children are aged 5 years.6 These co-occurring, behaviour problems are
of concern in early childhood because
of the importance
of these early years for longer term child developmental outcomes.7
However, when we examined the overall estimated probability
of meeting «caseness» on the GHQ - 12, neither child
core autism symptoms (social affect and restrictive and repetitive behaviours), nor child level
of speech, were associated with caregiver mental health difficulties.
As a measure
of parenting stress specific to
core and co-morbid
symptoms of autism, the APSI is unique.