«Many of the changes in canine lymphoma were exactly the same as in
corresponding human patients,» Breen says.
Using 80 of the successful tumor xenografts — from the Greek «xenos» meaning «foreign» — he compared how the mouse's tumor responded to a drug or drug combination with the treatment response of
the corresponding human patient.
Not exact matches
«Acute repeated spikes in blood sugar that you see with each dose of this drug have long - term impacts — and can predispose
patients to the development of insulin - resistance Type 2 diabetes and cardiovascular disease,» said David Wright, associate professor in the Department of
Human Health and Nutritional Sciences and
corresponding author of the paper.
«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in
patients remains a huge assumption,» says James Gusella, PhD, director of the Center for
Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH),
corresponding author of the Cell paper.
In collaboration with Dr. Josh Thaden and Vance Fowler, Duke University Medical Center, we are exploring relationships between bacterial genetic variation, emergence of AMR, and
patient outcome in Enterobacter and Escherichia coli Bloodstream Infections (BSI) by leveraging the Duke University Bloodstream Infection Biorepository (BSIB), which contains robust clinical data, bacterial bloodstream isolates, and
corresponding human sera and DNA from over 2000
patients with BSI caused by Gram - negative bacteria at Duke Hospital since 2002.
A new Pathology Atlas is launched today with an analysis of all
human genes in all major cancers showing the consequence of their
corresponding protein levels for overall
patient survival.