Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and
costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.
Evidence Implicating the Ras Pathway in Multiple CD28
Costimulatory Functions in CD4 + T Cells.
Not exact matches
Dr. Freeman's laboratory focuses on the identification and
function of T cell
costimulatory and coinhibitory pathways in regulating T cell activation and application of this knowledge to the development of more effective immunotherapies for cancer, infections, asthma, and autoimmune diseases.