Sentences with phrase «costimulatory pathways»

We are currently investigating the role of various T - cell costimulatory pathways in regulating the humoral and cellular responses to and between DENV and ZIKV, and are defining the particular pathways that should be targeted to maximize safety and efficacy of vaccines.

Dr. Sharpe's functional analysis of costimulatory pathways regulating T cell activation has led to understanding of (1) the roles of B7 - 1 and B7 - 2 as positive regulators through CD28 and (2) negative regulators through CTLA - 4, and (3) the role of PD - L1 and PD - L2 as negative regulators through PD - 1.

Not exact matches

Upregulation of costimulatory molecules induced by lipopolysaccharide and double - stranded RNA occurs by Trif - dependent and Trif - independent pathways.

Evidence Implicating the Ras Pathway in Multiple CD28 Costimulatory Functions in CD4 + T Cells.

Costimulatory and coinhibitory pathways together with metabolic pathways orchestrate the fate of lymphocytes after antigenic stimulation.

Dr. Freeman's laboratory focuses on the identification and function of T cell costimulatory and coinhibitory pathways in regulating T cell activation and application of this knowledge to the development of more effective immunotherapies for cancer, infections, asthma, and autoimmune diseases.