Sentences with phrase «coupled receptors»
"Coupled receptors" refers to a type of receptors found on the surface of cells in our body. These receptors are like little messengers that help cells communicate with each other. They receive signals from outside the cell and trigger various responses within the cell. The term "coupled" refers to the fact that these receptors work together with other molecules inside the cell to transmit the signals and initiate specific actions. Full definition
Our current research involves the study of a G - protein coupled receptor by single - molecule detection methods.
sciencemag.org
The molecule is known as a G protein - coupled receptor because it triggers so - called G proteins to bind to the inner side of a receptor and start a signal cascade.
The researchers were recognized for their groundbreaking work involving G - protein - coupled receptors which has provided an important framework for drug development.
The researchers developed computer models of the G protein - coupled receptors interacting with different drug compounds.
Plasma Membrane and Nuclear Localization of G Protein — coupled Receptor Kinase 6A.
About 30 percent of medications on the market activate G - protein coupled receptors on cell surfaces and trigger chemical signals inside cells to yield their therapeutic effects.
Specific canonical pathways enriched with such genes included PPAR signalling, cytokine signaling between immune cells and G - protein coupled receptor signalling (Table S2).
Essential role of cleavage of Polycystin - 1 at G protein - coupled receptor proteolytic site for kidney tubular structure.
A research group at SciLifeLab, led by Jens Carlsson at Stockholm University, has won a worldwide competition to predict the three - dimensional structure of a G protein - coupled receptor using computer modeling.
Chia - Shan Wu, Hongmei Chen, Hao Sun, Jie Zhu, Chris P. Jew, Jim Wager - Miller, Alex Straiker, Corinne Spencer, Heather Bradshaw, Ken Mackie, Hui - Chen Lu (2013) «GPR55, a G protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination», PLoS ONE, 8: e60314.
In the study, «Succinate and its G - protein - coupled receptor stimulate osteoclastogenesis,» the researchers took samples of bone marrow from hyperglycemic male mice and healthy mice.
When the researchers then administered acetylcholine to the mice through the nebulizer, they observed that mice with the G protein - coupled receptors reacted more vigorously than those with only smooth muscle reactions, and they also showed increased airway restriction compared to their counterparts without the receptor.
They found that mice with the G protein - coupled receptor breathed more quickly and with more effort after exposure to the receptor activator than mice lacking it, evidence that the receptors are activated before an asthma - like attack.
They found that stimulation of the G protein - coupled receptor increased airway constriction more than activating the airway smooth muscles alone.
Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.
The structure provides a high - resolution view of a human G protein — coupled receptor bound to a diffusible ligand.
Some of them acquired additional domains during evolution (e.g. DNA polymerase, mRNA export factor), whereas others show a combination of domain rearrangements and gene duplications (e.g. G - protein coupled receptor homologs, US22 domain proteins), and thus approach the complexity of eukaryotic protein family evolution.
The cannabinoid receptors are members of the guanine - nucleotide - binding protein (G - protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose - dependent, stereoselective and pertussis toxin - sensitive manner.
CXCR4 is a G - protein - coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems.
They are polymodal ion channels that are subjected to extensive regulation by a diverse set of physical (pH, temperature, mechanical force) and biological signals (lipids, G - protein coupled receptor pathways).
The same method estimates that various mammalian G protein - coupled receptors diverged some 90 million years ago, well before the demise of the dinosaurs.
One of the highly conserved proteins is the so - called G protein - coupled receptor shown in the picture.
G Protein - Coupled Receptor Trafficking in Health and Disease: Lessons Learned to Prepare for Therapeutic Mutant Rescue in Vivo
John Williams, PhD View the Video Senior Scientist, Vollum Institute Oregon Health & Sciences University G - protein Coupled Receptor dependent synaptic transmission
Her specific interests are in studying the G - protein - coupled receptor dynamicas as in the interaction of chemokines, and antagonists to the chemokine receptors, that trigger leukocyte migration in immune response and inflammation.
G - protein coupled receptors couple to different heterotrimeric G - protein complexes.
This talk is titled: «G protein - coupled receptors mediate neural regulation of innate immunity in C. elegans», Friday, April 27, 12:10 p.m.
EBI2 (GPR183) is a Gαi coupled receptor that responds to the oxysterol ligand, 7α,25 - hydroxycholesterol (OHC)(Hannedouche et al., 2011; Liu et al., 2011).
The final stage is headed by Jian Jin, a member of the UNC Lineberger Comprehensive Cancer Center, will develop new compounds that will allow researchers to even more precisely activate the G - coupled receptors of individual cell types in the particular brain regions.
This protein, designated «fusin,» is a putative G protein - coupled receptor with seven transmembrane segments.
In the future, Dong hopes to identify a compound that can block the G protein - coupled receptor on vagus nerves as a means of stopping airway «itch» and curbing asthma.
Host: Dr. Yu Tian Wang Speaker: Dr. Stephen Ferguson, Univ. of Ottawa Title: Role of G protein - coupled receptor signaling in diseases of the CNS
We have previously shown that recombinant human PC1 is cis - autoproteolytically cleaved at the G protein - coupled receptor proteolytic site domain.
A research group at SciLifeLab, led by Jens Carlsson, has won a worldwide competition to predict the three - dimensional structure of a G protein - coupled receptor using computer modeling.
G - protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N - arachidonoylethanolamide (also called anandamide or AEA) and 2 - arachidonoylglycerol (2 - AG)(PubMed: 9888857, PubMed: 22388959).
Dr. Conklin pioneered the field of using designer G protein coupled receptors (RASSLs) for tissue engineering.
The Royal Swedish Academy of Sciences said the two researchers had made groundbreaking discoveries, mainly in the 1980s, on an important family of receptors, known as G - protein - coupled receptors.
The largest class of human target proteins for drugs are the so - called G - protein - coupled receptors.
A widened role for β - arrestin includes control of two new signaling elements in addition to the G protein - coupled receptors.
We find that two molecules interact with mammalian Smo in an activation - dependent manner: G protein — coupled receptor kinase 2 (GRK2) leads to phosphorylation of Smo, and β - arrestin 2 fused to green fluorescent protein interacts with Smo.
The β2 - adrenergic receptor (β2AR) is a well - studied prototype for heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters.
Physicist Marshall Stoneham and his colleagues at University College London report they have constructed a specific mechanism based on the properties of so - called G - protein coupled receptors, which project from olfactory cells inside the nose.
To explore the effects of the receptor on the airway, the researchers used a protein called BAM8 - 22, which is an itch activator that specifically targets the G protein - coupled receptor, to induce a reaction.
To understand how omega - 3s curb inflammation, Jerrold Olefsky, an endocrinologist at the University of California, San Diego, and his colleagues trawled through the data on a family of proteins called G protein - coupled receptors, which can bind to a number of different fatty acids.