Sentences with word «coxsackievirus»

This drawing shows part of the atomic - level structure of coxsackievirus B3 polymerase, which is responsible for making copies of the virus genome.

Since the group B coxsackieviruses includes only six enterovirus types it may be possible to include all of them in the same vaccine.

Peersen's group seeks to understand the complex biochemical replication machinery of positive - sense single - stranded RNA viruses, a group that includes coxsackievirus, poliovirus, dengue and Zika.

The researchers used a virus called coxsackievirus B3 (CVB3) in their experiment.

The vaccine won't protect against HFMD caused by coxsackieviruses, though.

During outbreaks of coxsackievirus A6, «we saw a lot more kids with blisters than what was usually expected,» says Eileen Schneider, a medical epidemiologist at the Centers for Disease Control and Prevention in Atlanta.

Most of the time, the culprit is either coxsackievirus A16 or enterovirus 71.

If you've ever driven north on the 87 out of New York City, you've probably passed Coxsackie, the upstate New York town that provided the fecal samples that harbored the newly discovered coxsackievirus.

There are ongoing studies with injection of T - VEC into visceral lesions, and also of intravenous administration of intralesional therapies, such as coxsackievirus A21.

Studies have suggested that pathogens called coxsackieviruses might be more likely to mutate in hosts that are short on selenium, a metal involved in producing protective compounds called antioxidants.

More research is needed however to confirm the causal relationship between group B coxsackieviruses and type 1 diabetes and to find out the underlying mechanisms of how these viruses can initiate the type 1 diabetes disease process.

In preclinical research, tumor cells lysed by coxsackievirus A21 (CVA21), a naturally occurring «common cold» ICAM - 1 — targeted RNA virus, induced a secondary systemic host - generated antitumor immune response.

In one eye - opening review of recent research, Charles Drake, M.D., Ph.D., of Johns Hopkins, who is also a member of CRI's clinical trials network, discussed several cancer vaccines that are making progress, including coxsackievirus A21, an oncolytic virus vaccine being studied in late stage melanoma, and NewLink's algenpantucel - L in pancreatic cancer (HyperAcute ® pancreas).

Colorado State University researchers led by Olve Peersen, a professor in the Department of Biochemistry and Molecular Biology, have designed a genetic modification to one type of coxsackievirus that strips its ability to replicate, mutate and cause illness.

Since many kids who have the coxsackievirus do not develop symptoms but can be contagious, it is often hard to avoid HFMD if your child is in daycare or frequently around other kids.

Coxsackieviruses have relatively small genomes made of single - stranded RNA.

The demonstration of this poison pill in the coxsackievirus B3 could theoretically translate to other positive - sense RNA viruses, including those linked to asthma and to foot - and - mouth disease that is a major animal health concern in Europe and South America.

It has a funny name — coxsackievirus — but there's nothing funny about how this tiny germ and its close relatives sicken their hosts.

For their most recent work, the team focused on the coxsackievirus B3, which causes heart disease.

Named for a town in upstate New York, coxsackievirus is one of the culprits behind hand, foot and mouth disease, a common childhood illness.

However, the high sequence divergence in the fiber protein (Table 2), as well as the absence of fiber motifs conserved among adenoviruses that bind CAR [36], [37](coxsackievirus - adenovirus receptor) or CD46 [38], [39], [40](data not shown), suggest that neither of these two human adenoviral receptors may be the attachment receptor for TMAdV.

These findings are in line with other recent reports suggesting that group B coxsackieviruses can spread to the pancreas and damage the insulin - producing cells.

The results from these studies clearly show that members of the group B coxsackieviruses are associated with the risk of type 1 diabetes while the 35 other enterovirus types tested did not show such a connection.

Several other intralesional therapies (PV - 10, interleukin - 12 electroporation, coxsackievirus A21 [CVA21]-RRB- are entering later - stage testing.

PTBP1 is required for glucose - stimulated cap - independent translation of insulin granule proteins and Coxsackieviruses in beta cells.

CALM study: secondary endpoints of a phase II study of a novel oncolytic immunotherapeutic agent, coxsackievirus A21, delivered intratumorally in patients with advanced malignant melanoma.

Because all 30 viruses were highly related, they were called Coxsackieviruses, even though they were not isolated from that town.