Nevertheless, just as a fever spiking too high can
create problems of its own, increasing numbers and density of Aβ plaques in a hyperglycemic brain can initiate chain reactions of glycation and oxidation that serve to exacerbate
mitochondrial dysfunction, decreased ATP production, and cognitive decline.
Mitochondrial damage further drains cellular energy by
creating a disproportionate need for repair, perpetuating a vicious cycle.21
Mitochondrial dysfunction can affect immunity, digestion, cognition and any energy - intensive system within the body and is a key component of many chronic illnesses.