Replacement tissue that avoids rejection by a patient's immune system is a step closer to the clinic, as researchers have
created human embryonic stem cells carrying the DNA of specific adults.
They view this as a test run for
creating human embryonic stem cells in the same way (and according to the team, South Korean biologist Hwang Woo Suk seems to have accidentally accomplished this feat while executing his famously fraudulent human cloning experiment).
Because fertilized human embryos are far more accessible than unfertilized eggs, which can not be frozen and stored, extending the result to humans could lower the practical barriers against
creating human embryonic stem cells to study and potentially treat disease.
In 2006, Woo Suk Hwang had to retract two papers published in Science in which his team claimed it had used the technique employed in cloning Dolly the sheep to
create human embryonic stem cells matched to specific people who had various diseases.
Researchers have developed a new technique for
creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells.
Not exact matches
Benedict argued that non-conjugal reproduction such as in vitro fertilization had
created «new problems» ¯ the freezing of
human embryos, for instance, and the selective abortion of medically implanted embryos, together with pre-implantation diagnosis,
embryonic stem -
cell research, and attempts at
human cloning.
A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to
create the equivalent of
human embryonic stem cells (called induced pluripotent
stem cells) but without using or destroying embryos.
Scientists looking for new methods to make
human tissue have successfully used cloning technology to
create embryonic stem cells from skin
cells.
Although he never banned this research outright, President Bush limited federal funding for research to the
embryonic stem cell lines that existed before August 2001, thus drawing a line at destroying
human embryos
created after that date.
To make the HSCs, the Harvard group used
human skin
cells to
create induced pluripotent
stem cells (iPSCs), adult
cells researchers genetically reprogram to an
embryonic -
stem -
cell state, where they can grow into any kind of
cell.
Eighteen adults with severe eye disease who were among the first people to receive transplants
created from
human embryonic stem cells (hESCs) continue to have no apparent complications with the introduced
cells after an average of nearly 2 years, according to the latest status report on their health.
The bill was put forth to loosen the restrictions Bush placed on
human embryonic stem cell research on August 9, 2001, when he banned federal funding for work with any
stem cell line
created after that date.
The result — the second such finding in the past year — suggests that similar
cells from
human testicles might have similar powers, paving the way to
creating replacement tissue for men who have suffered damage from heart attacks or other injuries and avoiding some of the controversy surrounding
embryonic stem cells (ESC).
What we discovered is that we can
create literally millions or billions of these from
human embryonic stem cells.
Scientists have
created red blood
cells from
human embryonic stem cells, in a step that they say could mean an infinite source of blood for transfusions.
A new paper in the journal
Cell claiming to have achieved breakthrough stem cell work — using cloning to create personalized human embryonic stem cells — is coming under serious scrut
Cell claiming to have achieved breakthrough
stem cell work — using cloning to create personalized human embryonic stem cells — is coming under serious scrut
cell work — using cloning to
create personalized
human embryonic stem cells — is coming under serious scrutiny.
Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor
cells derived from
embryonic stem cells and from
human fetal brain tissue can successfully
create myelin sheaths around nerve
cells, sometimes leading to dramatic improvements in symptoms.
Because embryos are not destroyed to
create them, they have been hailed as a way out of the ethical dilemma posed by
human embryonic stem cells.
Since its inception, CIRM has sought to
create a system from the ground up for funding research on
human embryonic stem cells to fill in the gaps left by federal funding restrictions (ScienceNOW, 12 April).
One team in Japan, and another in the US, have independently shown it is possible to produce
embryonic - like
stem cells directly from a patient's own skin
cells without having to
create and destroy a cloned
human embryo first.
According to a new analysis, the
cell line they
created represented the first example of parthenogenetic
human embryonic stem (ES)
cells.
Using a technique called COSMIC (Crosslinking of Small Molecules to Isolate Chromatin), the researchers were able to
create polyamides that would bind to DNA in
human embryonic stem cells.
Though Hwang Woo - suk, a South Korean scientist claimed to have
created the first
human embryonic clone and derived a
stem -
cell line from it in 2004 his work was later shown to be fraudulent.
Benedict argued that non-conjugal reproduction such as in vitro fertilization had
created «new problems» ¯ the freezing of
human embryos, for instance, and the selective abortion of medically implanted embryos, together with pre-implantation diagnosis,
embryonic stem -
cell research, and attempts at
human cloning.
Patent explosion Meanwhile, science is rapidly advancing in the field of
creating induced pluripotent
cells, which like
human embryonic stem cells can be manipulated to form other
cells.
What Collins does not say, however, is that the new NIH guidelines also allow for federal funds to be used in studying new
human embryonic stem cell lines that are
created (by private entities, of course) beyond the 700 currently in existence.
The new NIH guidelines do not permit the use of federal funds for
creating new
human embryonic stem cell lines.
Two months ago, several scientists in Wisconsin and Japan announced that they had successfully
created a type of
stem cell from ordinary
human skin
cells that seems to be able to function exactly like an
embryonic stem cell without the need to
create or destroy
human embryos.
Differentiation of
human pluripotent
stem cells (
embryonic stem cells (hESCs) and induced pluripotent
stem cells (hiPSCs)-RRB- may be a useful strategy to
create the supply to meet the high demand, although this currently remains inefficient or includes the use of xenogeneic and undefined reagents.
The Food and Drug Administration in November approved the company's plans to test
cells created from
human embryonic stem cells on 12 patients suffering from each condition.
Researchers have treated the first two patients in the second government - authorized attempt to evaluate a therapy
created using
human embryonic stem cells in the United States.
2007 also saw one of the most game - changing developments in the
stem cell field; researchers learned how to
create cells like
embryonic stem cells, but instead of coming from an embryo these
cells are
created from adult
cells, potentially
cells from any tissue in the
human body.
Virtually identical to
human embryonic stem cells (hESCs) except for their origin of isolation, the recently
created induced pluripotent
stem cells (iPSCs)(Yu et al., 2007; Takahashi et al., 2007) hold much potential for use in regenerative therapies.
Government regulators have given the go - ahead to a second study that will for the first time carefully test a treatment
created using
human embryonic stem cells in people, according to the company sponsoring the experiment.
The first reports of the successful reprogramming of adult
human cells back into so - called induced pluripotent
stem (iPS)
cells, which by all appearances looked and acted liked
embryonic stem cells created a media stir.
Stice's neural
cell kits
created from
human embryonic stem cell lines last up to six months.
In the new study, 12 patients will be treated with healthy scavenger
cells,
created in a laboratory from
human embryonic stem cells.
Created in 2005 through a collaboration between Inserm — National Institute of Health and Medical Research — and AFM - Telethon — French Association against Myopathies — I -
Stem is the largest French laboratory for research and development dedicated to human pluripotent stem cells, of embryonic origin or obtained by reprogramming g
Stem is the largest French laboratory for research and development dedicated to
human pluripotent
stem cells, of embryonic origin or obtained by reprogramming g
stem cells, of
embryonic origin or obtained by reprogramming gene.