Sentences with phrase «creating cell models»

The development offers a major technological advance in creating cell models of genetic diseases.

By reprogramming skin cells into nerve cells, researchers at Karolinska Institutet are creating cell models of the human brain.

To create cell models for the discovery of disease etiology, progression, and treatment, isogenic cell lines can be created from healthy or sick individuals, then compared (Figure 1).

My vision was to create a cell model in Minecraft that students could explore and manipulate.

Not exact matches

Scientists hope to eventually get to the point where they can create a computer model of a human, or even just the molecular workings of a human cell, but that's still a dream with the next step being the modeling of larger and more complex bacteria.

Whether you're an attractional model, a traditional model, or a seeker church, no matter if you're a house church, a cell church, or an urban mega-church, no matter if you're the guy who truly believes he's creating a whole new way to do church, there is one essential that must trump all others... Jesus.

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

By creating an experimental model of leukemia in mice whose cancer cells were resistant to chemotherapy the team was able to caracterize these cells» metabolic profile and observed certain modifications at the level of the mitochondria.

Again, using mouse models of glioblastoma — this time created from brain tumor cells that were resistant to the herpes virus — the therapy led to increased animal survival.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

«I can now take virtually any organism and manipulate the genome and create model systems where I can track cells, manipulate genes,» says Gitlin.

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

The distribution of fluorescent daughter cells can be used to create a mathematical model of blood formation, which can provide new insights into the behavior of stem cells.

In a paper published in Nature Immunology in 2011, Dr. Rostami and colleagues showed that the Th - 17 cells also produced another cytokine called GM - CSF, which created a chain reaction with another cell type ultimately increasing the GM - CSF levels in the brain of mouse models significantly.

This is particularly important as it indicates the method can be used in a variety of cell types to create disease models and contribute to the discovery of new disease - specific therapeutics.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

Using an animal model, the UAB researchers found that a lack of Sp7 interrupts the maturation of two types of specialized cells that help create teeth.

«Investigators create complex kidney structures from human stem cells derived from adults: New technique offers model for studying disease, progress toward cell therapy.»

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

At Brandeis, Seth Fraden, professor of physics, and Irv Epstein, the Henry F. Fischbach Professor of Chemistry, created rings of synthetic, cell - like structures with activating and inhibiting chemical reactions to test Turing's model.

Eggan has also been itching to use cloning technology to create embryonic stem cells that could be used to model the development of various diseases, especially diabetes and ALS.

Importantly, these devices also will open up new approaches to drug development not possible with animal models today, such as personalized medicines and development of therapeutics for specific genetic subpopulations using chips created using cells from particular patients.»

We created a mouse xenograft model in which SiHa cervical cancer cells were injected into mice subcutaneously, and the resultant tumors were treated with PAL three times a week for 6 weeks.

Wild H5N1 viruses can not latch on tothe cells in a person's nose and throat, but the mutant strains created by Fouchier and Kawaoka can spread between ferrets, which are viewed as a good animal model of flu transmission between humans.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

Existing cell culture models were not very realistic, Tuveson says, and creating genetically engineered mice took up to a year, compared with up to 3 weeks for pancreatic cancer organoids.

Allen will also fund two new $ 30 million research centers at Stanford University in Palo Alto, California, and Tufts University in Boston; Stanford researchers will model how bacteria interact with immune cells, whereas the Tufts group will seek to crack the biological code that determines how tissues are created.

In recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»

The team from the cluster of excellence BrainLinks - BrainTools and the Bernstein Center at the University of Freiburg and the UNIC department of the French Centre national de la recherche scientifique in Gif - sur - Yvette created a computer model of networks of nerve cells and analyzed its properties for signal propagation.

A new technique — called DNA Programmed Assembly of Cells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

The new technique — called DNA Programmed Assembly of Cells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hCells (DPAC) and reported in the journal Nature Methods on August 31, 2015 — allows researchers to create arrays of thousands of custom - designed organoids, such as models of human mammary glands containing several hundred cells each, which can be built in a matter of hcells each, which can be built in a matter of hours.

In a study spanning molecular genetics, stem cells and the sciences of both brain and behavior, researchers at University of California San Diego, with colleagues at the Salk Institute of Biological Studies and elsewhere, have created a neurodevelopmental model of a rare genetic disorder that may provide new insights into the underlying neurobiology of the human social brain.

The team modelled how the membrane changed, enabling LUCA's descendants to move to new, more challenging environments and evolve into two distinct types of single - celled organism, bacteria and archaea, creating the deepest branch of the tree of life.

Demirci's Stanford team created the overall experimental device designs based on Tüzel's theoretical models, fabricated and tested the prototypes, and determined the best experimental parameters and medium for the sperm cells to swim through the device.

Along with his colleagues, Shaqfeh has now created the first simplified computer model of the process that forms that layer — a model that could help to improve the design of artificial platelets and medical treatments for trauma injuries and for blood disorders such as sickle cell anemia and malaria.

The ultimate goal is to use stem cells of an individual patient and create a personalized model of their reproductive system.

Ultimately, the goal is to use stem cells of an individual patient and create a personalized model of their reproductive system to test new drugs for safety and effectiveness.

Professor Alvaro Mata, from Queen Mary's School of Engineering and Materials Science, said: «The technique opens the possibility to design and create biological scenarios like complex and specific cell environments, which can be used in different fields such as tissue engineering by creating constructs that resemble tissues or in vitro models that can be used to test drugs in a more efficient manner.»

You would create a mouse model of attention deficit / hyperactivity disorder (ADHD) or depression and dose the rodent with molecules carefully designed to close one cell receptor or open another.

Using a three - dimensional model of mammary cell development created by Dr. Sentil Muthuswamy, formerly of CSHL and now at the University of Toronto, the team tested to see if abnormal growth initiated by HER2 signaling would be either enhanced or reduced if any of the 37 PTPs was experimentally «knocked down.»

For example, if the process were used to create liver cells for a drug test, the resulting product «would actually have vascularization in it that is modeled on how a liver works.»

«Micro heart muscle created from stem cells: New technique offers cheaper, faster method to create heart tissue for testing drugs and modeling disease.»

The technique «potentially provides ways to create model systems for studying the genetic basis of diabetes, or to discover novel therapies to enhance existing β cells,» Ferrer says.

Researchers at the University of California, Berkeley, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and a drug - screening tool to make pregnancies safer.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.

However, the study led by Pyle found that the current methods are inefficient; they produce immature cells that are not appropriate for modeling Duchenne in the laboratory or creating a cell replacement therapy for the disease.

Therefore, it was critical to develop a human neural cell model to understand the neurodegenerative process of A-T and create a platform for testing new treatments.

To better understand this sensitivity, a cross-disciplinary team of researchers led by Yale created models of the mutation in cell cultures.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.