Sentences with phrase «creating gene knockouts»
Other groups in England and Japan were also working on creating gene knockouts in human cells, targeting other genes.
https://gumc.georgetown.edu/ Not exact matches
To find out what BRCA2 does normally, the team reporting the new results, which includes Allan Bradley of Baylor College of Medicine in Houston and Paul Hasty of Lexicon Genetics Inc. in The Woodlands, Texas, created «knockout» mice in which the gene was inactivated.
Instead of using the traditional method of introducing genetic mutations into mice to create «knockout» mice — or animals with customized genes — they found they were able to find naturally occurring variants among animals in the wild.
As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.
In partnership with several international programs, the initial five - year phase of KOMP will reach its goal of creating knockout mouse embryonic stem cell lines for each of the approximately 21,000 protein - coding genes in the mouse genome this year.
Transgenic and gene knockout / knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.
To address this challenge, the International Mouse Phenotyping Consortium is creating a genome - and phenome - wide catalog of gene function by characterizing new knockout - mouse strains across diverse biological systems through a broad set of standardized phenotyping tests.
To assist drug development through the identification of essential genes and pathways, we have measured competitive growth rates in mice of 2,578 barcoded Plasmodium berghei knockout mutants, representing > 50 % of the genome, and created a phenotype database.
Collaboration between Genentech Inc. and Lexicon Pharmaceuticals Inc. created a mouse knockout library targeting genes encoding secreted and trans - membrane proteins.