The initial experiments made use of cancer cells that Quiñones - Hinojosa and his team removed from willing patients and grew in the laboratory until they formed little spheres of cells, termed oncospheres, likely to be the most resistant to chemotherapy and radiation, and capable of
creating new tumors.
Metastasis is the process in which cells from a primary tumor break - off, enter the blood stream and
create new tumors elsewhere in the body.
If they are not completely destroyed they are capable of continuous differentiation, they able to self renew and
create new tumor colonies.
Not exact matches
The ambitious plan was to
create a
new shared resource of
tumor samples with attached patient information.
But a
new study suggests that mutations in a
tumor - suppressing gene can
create a prime nesting ground that grows
new blood vessels to feed the
tumor.
His laboratory develops and deploys
new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to
create and deploy novel techniques in next - generation sequencing and algorithms for
tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.
Researchers have
created a
new drug delivery system that could improve the effectiveness of an emerging concept in cancer treatment — to dramatically slow and control
tumors on a long - term, sustained basis, not necessarily aiming for their complete elimination.
One implication is cancer patients with few mutations in their
tumors might respond better to PD - 1 inhibitors if they first receive radiation or chemotherapy, because these treatments can
create new mutations in
tumors.
«The surprise was how well this worked in clearing so much
tumor so rapidly,» says immunologist Bruce Levine of the University of Pennsylvania, one of the scientists who
created the
new treatment.
This permits
new insights into organisms and
creates the potential for a wide range of applications — from more exact delineation of
tumor and metastasis through to tracking drug responses within whole - body imaging.
Some
tumors may take advantage of the latter ability to
create new blood vessels that support their ability to grow.
The IFOM - IEO Campus was
created with this view in mind, with the aim of developing and applying genomic research to the field of oncology, providing a substantial contribution to the quick translation of emerging scientific knowledge into
new strategies for the prevention and treatment of
tumors.
P53: The protein p53 plays the role of
tumor suppressor, but
creating a general increase in p53 levels will, in addition to reducing cancer incidence, also accelerate aging by reducing tissue maintenance through the creation of
new cells.
Wistar researchers also
create new tools for melanoma research, including three - dimensional «artificial skin» that serves as a model for studying how living
tumors behave, as well as a proving ground for
new therapeutics.
New data and research approaches have
created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to
tumors.
His analysis of all publicly available cancer mutations and integration with all solved computational models of human proteins has
created a powerful roadmap for evaluating
new mutations observed in patient
tumors.
A brain -
tumor surgery left Flora unable to
create new memories.