Sentences with phrase «creating organ models»

But I realized that, practically, I could have a lot more impact creating organ models.»

Creating organ models on a microscale has been greatly facilitated by microfluidics, a technology developed in the 1990s that uses micropumps, valves and finely etched channels to manipulate the movement of fluids through a chip.

Not exact matches

The skeleton, the blood vessels, organs, all of it, were simply augmented - reality images emanating from the Microsoft HoloLens visors we were wearing — and created by an ingenious software model developed by Dr. Mark Griswold, a professor of radiology at Cleveland's Case Western Reserve University, and his team.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

The US Defense Advanced Research Projects Agency (DARPA) is funding the integration of 10 individual organs - on - a-chip to create a miniature model of the human body.

A team of researchers from the Massachusetts General Hospital (MGH) Center for Engineering in Medicine (MGH - CEM) have created a «liver on a chip,» a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive patterns of liver damage caused by exposure to environmental toxins, including pharmaceutical overdose.

«Organ development, especially the liver, is highly conserved among vertebrates — including zebrafish — and the mutations we create in zebrafish alter embryogenesis in a manner consistent with humans, making it an ideal model system to study diseases such as Alagille syndrome.»

IN ANY KIND OF TISSUE ENGINEERING — whether the aim is to create transplantable organs or miniature organ - on - a-chip models — researchers sometimes depend on stem cells that can adapt themselves to the purpose at hand.

GRIFFITH WAS HARDLY THE ONLY PERSON to make the intellectual leap from engineering organs to creating better models of them.

So using as few of them as possible to create models of human tissue and organs saves money.

This technical article details multiple challenges involved in linking multiple organs on chips to create systems that realistically model human physiology.

We build up bio-matrices with defined chemical composition to mimic their environment under physiological and pathological conditions, to supply nutrition, to provide signaling, to create polarized conditions, and to, ultimately, allow us to perform cell - based drug screening in 3D model organs.

«Previous methods of using 3 - D printers and a single material to create human organ models were limited to the physiological properties of the material used,» Zhang said.

BUT ORGANS ON CHIPS ARE N'T USEFUL ONLY as a way to create more realistic models of healthy, functioning organs; the miniature versions can also replicate what happens when things go ORGANS ON CHIPS ARE N'T USEFUL ONLY as a way to create more realistic models of healthy, functioning organs; the miniature versions can also replicate what happens when things go organs; the miniature versions can also replicate what happens when things go wrong.

«As examples, scientists could use Organ - Chips to create a living model of a patient with Parkinson's disease, amyotrophic lateral sclerosis or Crohn's disease, a debilitating inflammatory bowel disorder linked to several gene mutations.

This postdoctoral fellow is expected to develop and lead an interdisciplinary research project aimed at creating microengineered human «organ - on - chip» models and exploring their use for drug discovery applications.

Conventional medicine, as you called it earlier, was created in response to mainly acute disease where you have a single cause and single effect, and now medicine is trying to adapt to this now environment of chronic disease, which is driven by lifestyle, it's multi-systemic, it's across many different organs, and so that linear model of thinking doesn't really work.

For instance, such professionals may need to create 3D models of different human organs to assist in the field of medical research.