NYSCF — Robertson Investigator Alumna Dr. Shuibing Chen published her latest work in Cell Stem Cell
creating stem cell models of type 2 diabetes in a...
After
creating a stem cell model of the disease from patients» skin cells, the Scripps Research scientists found strong evidence for the involvement of a DNA repair enzyme in the FXN triplet repeat expansion.
After
creating stem cell aggregates with microparticles containing different growth factors, the researchers observed a hemispherical organization of cells for several days, with the different cells remaining spatially segregated.
In the face of these setbacks, many scientists have focused on new methods of
creating stem cell lines without destroying embryos.
Since 2004, several groups have reported
creating stem cell lines through parthenogenesis.
Fabrication and falsification raise further concerns about claims for a new and easy way to
create stem cells.
The newly
created Stem Cell Network is a cross-country coalition of stem cell researchers that also aims to create a critical mass of stem cell scientists.
Scientists in the United States have been trying to find ways around the ban on using federal funds to
create stem cells from human embryos.
The project has been restarted, and researchers are exploring new ways to
create stem cells.
Kevin Eggan's lab in Cambridge has been busy demonstrating the clinical potential of the research — and finding novel ways to
create stem cells.
«As researchers started using these cells more, it became clear that during the process of reprogramming to
create stem cells the cell was also rejuvenated in other ways,» says Jerome Mertens, a postdoctoral research fellow and first author of the new paper.
The 30 - year - old was widely celebrated when she and colleagues published two papers in Nature describing a new and surprisingly simple way of
creating stem cells, which the researchers dubbed stimulus - triggered acquisition of pluripotency (STAP) cells.
Obokata maintains that her main finding of a new way to
create stem cells is valid but admits making innocent mistakes in handling images and text in the papers.
RIKEN launched an investigation after claims of image manipulation and plagiarism surfaced regarding a research article and a letter published online in Nature on 29 January that described a new, simple way of
creating stem cells called STAP, for stimulus - triggered acquisition of pluripotency.
The creator of Dolly the sheep has ended his focus on somatic cell nuclear transfer, or cloning, in favor of another approach to
create stem cells
The committee's final report (in Japanese), released today, is the latest blow against a surprisingly simple method for
creating stem cells, known as STAP (stimulus - triggered acquisition of pluripotency), published in a Nature article and an accompanying letter online on 29 January by Obokata and colleagues at RIKEN CDB, along with other institutions in Japan and at Harvard Medical School in Boston.
Ploegh envisions the technique being used to create a new type of personalized therapy in the future — your own cells could be isolated, used to
create stem cells that differentiate into erythroblasts, genetically modified to carry a molecule, and reinjected into your body.
Efforts in the past to
create stem cells have typically involved finding ways to take target cells and «dedifferentiate» them into multipotent cells, but this is typically a painstaking process.
This reprogramming method
creates stem cells that can create any cell type while also maintaining the genetic code of the person they originated from.
Second, and even more noteworthy, scientists can now
create stem cells with all the same properties as those derived from embryos without killing — or even using — embryos at all.
«Since that time, Lorenz has made a significant number of transformative contributions and developed protocols that have fundamentally changed the way
we create stem cells in the lab,» said Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease.
However, if the new method does work as well in people as it seems to do in mice, then it offers an exciting new way to
create stem cells.
Now researchers have found a way to
create stem cells that mimic the universal role of embryonic cells.
What MSC - secreted factors are important for chondrogenesis and can we use this information to
create a stem cell - free therapy?
Scientists at Gladstone now
create stem cells from the skin cells of patients with a specific disease, which helps them to study the causes of disease and find novel treatments.
The Broad Foundation is the largest nongovernmental donor to stem cell research in California, having given $ 75 million to support or
create stem cell centers at UCSF, USC and UCLA.
Not exact matches
Benedict argued that non-conjugal reproduction such as in vitro fertilization had
created «new problems» ¯ the freezing of human embryos, for instance, and the selective abortion of medically implanted embryos, together with pre-implantation diagnosis, embryonic
stem -
cell research, and attempts at human cloning.
Meanwhile, the February 2 issue of the New Scientist noted the work being done with
stem cells to
create «female sperm» and «male eggs.»
A few weeks ago we all heard the announcement of a major scientific breakthrough that allowed scientists to
create the equivalent of human embryonic
stem cells (called induced pluripotent
stem cells) but without using or destroying embryos.
Recent reports of scientists
creating «ethical» embryonic
stem cells are false or misleading.
One of the key caveats at the time, however, was that the technique required the use of a virus to introduce several genes into the skin (or other)
cell, and these would remain in the
cell, and so might contaminate the resulting
stem cell or
create cancer risks.
The only problem I have is
creating fetuses in a lab to extract more
stem cells.
• A mover and shaker in the National Institutes of Health promotion of
creating and killing human embryos in
stem cell research is Brigid Hogan, a British researcher at Vanderbilt University.
Scientists looking for new methods to make human tissue have successfully used cloning technology to
create embryonic
stem cells from skin
cells.
Such a single - step conversion of an adult
cell into an embryonic
stem cell entirely avoids the question of whether an embryo has been
created, since the
cell produced by ANT - OAR never exhibits any of the properties of a single -
cell embryo.
Shinya Yamanaka, since 2004 a professor at Kyoto University's Institute for Frontier Medical Sciences, has had great success recently in
creating suitable
stem cells from adult
cells instead of from living embryos.
A pluripotent state makes the resulting
cells indistinguishable from embryonic
stem cells, and the scientists got these
cells without
creating or destroying any embryos.
The scientific question is whether embryonic
stem cells produced with the Dolly method are superior to those
created with the iPS method.
Although he never banned this research outright, President Bush limited federal funding for research to the embryonic
stem cell lines that existed before August 2001, thus drawing a line at destroying human embryos
created after that date.
There has been much handwringing about the news that scientists injected human
stem cells into pig embryos,
creating a mostly - pig - but - a-little-bit-human chimera.
For therapeutic or embryo cloning, the objective is not to
create adult animals, but to extract
stem cells for research from the cloned embryos
created.
Frankenbunnies Embryos made by Chinese researchers who fused human skin
cells with rabbit eggs, hoping to
create a source of
stem cells.
In a study in the journal Science, researchers explain how they used mouse embryonic
stem cells and microchip technology to
create heart muscle tissue that actually beats.
Researchers used
stem cells to
create retinal pigment epithelium
cells, which were transplanted into a patient's retina (left) in an area depicted by the black circle.
To make the HSCs, the Harvard group used human skin
cells to
create induced pluripotent
stem cells (iPSCs), adult
cells researchers genetically reprogram to an embryonic -
stem -
cell state, where they can grow into any kind of
cell.
Since the first human brain organoids were
created from
stem cells in 2013, scientists have gotten them to form structures like those in the brains of fetuses, to sprout dozens of different kinds of brain
cells, and to develop abnormalities like those causing neurological diseases such as Timothy syndrome.
Levels of NAD dropped, and the neural
stem cells stopped dividing; they stopped renewing themselves; and they stopped being able to
create important
cells that insulate axons, the «wires» that carry electrical signals throughout the brain.
Alysson Muotri at the University of California, San Diego, and his team
created the mini-brains by exposing
stem cells taken from the pulp of children's milk teeth to cocktails of growth factors that help them mature.
A similar trial of RPE
cells created from induced pluripotent
stem cells (iPSC)-- adult
cells that are transformed into
stem cells — also showed some success last year.
Although liver
cells created from induced pluripotent
stem cells reflect the defects of their source, they may offer a new tool to study inherited disorders