Sentences with phrase «critical role in diseases»

Despite what you might have been told, we've known for some time that neurogenesis (the growth of new neurons in the brain) can occur in the hippocampus of the brain, which plays a critical role in diseases like Alzheimer's and dementia and influences emotional behavior and cognition.

«These events predict a worse outcome in TNBC patients suggesting that the LINK - A pathway plays a critical role in this disease and may provide wide - ranging therapeutic treatment targets.»

Since apoE plays a critical role in the transport of cholesterol and fats to the brain, it can be hypothesized that insufficient fat and cholesterol in the brain play a critical role in the disease process.

Not exact matches

Learn more about this topic in our essay Opening Pandora's Bread Box: The Critical Role of Wheat Lectin in Human Disease.

«By refusing to earmark funds for critical resources and research, the Governor once again passed up the chance to play an active role in helping to combat the spread of a disease that has wreaked havoc on thousands of NY families.»

Public health professionals play a critical role in monitoring a population's health, controlling disease, and fostering policies to improve and promote health and health services.

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryIn a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryin disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryin the embryo.

«Our ground - breaking discovery that bacteria and fungi both play a critical role in health and disease has tremendous implications not only for understanding the disease process, but also for development of potentially life changing treatments for those who suffer from chronic digestive diseases,» concluded Dr Ghannoum.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

Now, Salk scientists have developed a highly sensitive, new method that enables them to detect fleeting protein interactions that play critical roles in the development of many diseases including cancer.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

Prof. Mandelboim and his research collaborators found that the NKp46 receptor present on Natural Killer or NK cells (an essential part of the immune system) play a critical role in the development of the disease in mice.

As many of these diseases have no effective treatment, future studies examining the role of glucose in regulating neutrophils and inflammation are critical.»

Transport of engineered nano - particles loaded with drugs or bio-molecules to the site of the disease in pathophysiologic states in humans plays a critical role in determining the efficacy of therapeutic management.

Sugars play critical roles in many cellular functions and in disease.

Along the way, the experiments have resulted in important information on how MS attacks the body, says Stephen Hauser, a neurologist at the University of California, San Francisco, whose lab spent decades determining the critical role B - cells play in the disease.

Given the critical role livestock play in Mongolia, transmission of tick - borne diseases can have very real health and economic implications for livestock and the herders that tend to them.

Neuroscientists have discovered a specific enzyme that plays a critical role in spinal muscular atrophy, and that suppressing this enzyme's activity, could markedly reduce the disease's severity and improve patients» lifestyles.

Lee and Cate's research hints that this secret lever, which triggers translation of only a special subset of mRNAs — perhaps only 500 out of some 10,000 mRNAs produced by a cell — will be found to play a critical role in other diseases besides cancer, as well as in plants and animals.

This plays a critical role in the development of organisms and also, when it goes awry, in disease.

«This work exactly illustrates the critical role that basic science conducted in partnership with a world - class medical center can play in advancing knowledge in an attempt to fight a devastating disease.»

As our knowledge of the role of pathogen and host genomic factors in the prevention and treatment of infectious disease expands, it is critical that we evaluate current legal frameworks to determine the extent to which current genetic privacy laws - for example, both state and federal in the US - may hinder our ability to use genetic information to protect the health of both individuals and the general public.

We discuss the critical role of the BRCA gene family in signaling pathways (including angiogenesis) and evaluate the impacts of the loss - of - function mutations associated with the aforementioned disease.

The diverse set of antagonists described in this article will be useful in guiding medicinal chemists to rationally design effective CXCR4 antagonists for the treatment of human diseases where SDF - 1 / CXCR4 axis plays a critical role.

This finding underscores the role of genetics in the pathogenesis of this devastating illness, and represents a critical milestone on the way to identifying a gene and its disease - linked variants.

It has a critical role in regulating cell proliferation, so understanding ERK regulation is central to efforts to design new cancer drugs and other disease therapies.

Such changes in neuronal function are likely to play important roles in all normal physiological processes in the brain and are critical for development of a variety of brain diseases, including Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, drug dependence and other neurological and psychiatric disorders.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

The hippocampus plays a critical role in learning and memory and is the brain region that is often an early casualty of Alzheimer's disease.

Critical to ethical review is a cost / benefit analysis; the welfare cost to the animals must be balanced by the benefit of knowledge gained into gene function and the role of genes in human health and disease.

We believe that the use of DNA binding agents such as Hoechst can be used to target exposed DNA in other diseases where necrotic cell death plays a critical role and could be used as a platform therapy.

«It's critical that we more clearly understand the role that human decisions play in transmitting disease.»

The characterization of viral consortia in healthy, diseased, and different life stages of corals will provide scientists clues about the roles that viruses play in the establishment, health, and resilience of these critical ecosystem engineers.

These data define a critical role for MORC2 in epigenetic silencing by the HUSH complex and provide a mechanistic basis underpinning the role of MORC2 mutations in CMT disease.

Specifically, the team hypothesizes that microRNA miR - 24 is a key regulator of actin cytoskeleton dynamics (i.e. the inner structural support of a cell); therefore, it plays a critical role in regulating multiple disease processes, including the angiogenesis (blood vessel growth), inflammation, and fibrosis (thickening and scarring of tissue) associated with choroidal neovascularization (CNV) in wet AMD.

Thus, in order to link a person's microbiome to body mass index (BMI) or disease, it is critical to know which genes are present and what role they play.

Our laboratory focuses on the structure and function of apolipoprotein (apo) E, including its critical role in cholesterol homeostasis, atherosclerosis and neurodegenerative disorders such as Alzheimer's disease and traumatic brain injury.

Vitamin A is key to almost every process in the body — the concert master, so to speak — not only for protein synthesis, but also for hormone production (including sex hormones like testosterone, and thyroid hormone); vitamin A is also key to immune system function, critical for healthy vision and hearing, plays a role in bone health, and works in tandem with vitamins D and K2 for everything from the prevention of heart disease to the production of feel - good chemicals.

In this master class, we go in - depth on the gut - immune connection and why leaky gut plays a critical role in the progression of autoimmune diseasIn this master class, we go in - depth on the gut - immune connection and why leaky gut plays a critical role in the progression of autoimmune diseasin - depth on the gut - immune connection and why leaky gut plays a critical role in the progression of autoimmune diseasin the progression of autoimmune disease.

Opening Pandora's Bread Box: The Critical Role of Wheat Lectin in Human Disease.

PCOS Challenge is the leading voice for women and girls with PCOS and our programs play a critical role in helping those affected by the condition overcome their struggles with infertility, weight gain, hirsutism, anxiety and depression and reduce their risk for numerous life - threatening related diseases.

Vaccinations play a critical role in establishing safeguards against some of the most widespread and dangerous diseases your pet may ever face.

Veterinarians also play a critical role in educating owners on proper husbandry practices, often a key element in disease prevention and detection.

Dr. Cezar started her career at APHIS serving as a Veterinary Medical Officer, a role under Veterinary Services, where she worked firsthand in surveillance of critical public health diseases such as Chronic Wasting Disease and Scrapie.

Sometimes the actions of one gene may be more critical than the others that play a role in a disease.

These two tests will be critical to ruling out any potential diseases that may be playing a role in your dog's current condition.If all of these attempts remain unfruitful, your veterinarian will likely want to x-ray your dog to rule out any possible obstruction that may be responsible for straining or explosive diarrhea.

www.komen.org — «Since 1982, Komen has played a critical role in every major advance in the fight against breast cancer, transforming how the world talks about and treats this disease and helping to turn millions of breast cancer patients into breast cancer survivors.»

Given the critical role of the veterinary profession in public health, the CVMA is committed to robust animal disease surveillance programs, disaster planning and other public health initiatives.

Dog vaccinations play a critical role in protecting your dog from many dangerous and even fatal diseases.

Ecosystems play a critical role in limiting the spread of human and non-human diseases.