Sentences with phrase «critical roles in cancer»

Given that S1P cause cell survival, proliferation, migration and angiogenesis, we hypothesized that S1P play critical roles in cancer progression.

«Immune cells play critical roles in cancer.

The proteasome complex is present in all multicellular organisms, and plays a critical role in cancer by allowing cancer cells to divide rapidly.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

Not only does selenium play a critical role in cancer prevention as a cofactor of glutathione peroxidase, selenium also works with vitamin E in numerous other vital antioxidant systems throughout the body.

Not exact matches

More data are needed to understand its clinical value but, if results are favorable, this imaging agent could play a critical role in the standard of care for prostate cancer.»

A study published this week in PLOS Medicine suggests that epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer.

The genetic circuit produces the machinery necessary for the production of a compound that inhibits a protein which has a significant and critical role in the growth and survival of cancer cells.

Now, Salk scientists have developed a highly sensitive, new method that enables them to detect fleeting protein interactions that play critical roles in the development of many diseases including cancer.

«Mus81 really does play a critical role» in suppressing tumors, says Stephen West, a biochemist at Cancer Research UK in London.

A rare - stem like tumor cell, which plays a critical role in the spread of breast cancer, is identified with immunostaining for the?

Enzymes that chemically modify DNA, known as DNA methyltranferases, play critical roles in regulating gene expression during development, but their role in cancer formation is less clear.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researcancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researCancer Center researchers.

Opioids also play a critical role in pain management regimes for cancer patients.

In a recent series of studies researchers identified a previously unknown critical role for a potential cancer causing gene, Bcl3, in metastatic breast canceIn a recent series of studies researchers identified a previously unknown critical role for a potential cancer causing gene, Bcl3, in metastatic breast cancein metastatic breast cancer.

Dr. Ella Evron and Dr. Ayelet Avraham of the TAU - affiliated Assaf Harofeh Medical Center, together with Prof. Saraswati Sukumar of Johns Hopkins, have found that «gene regulation,» the process that shuts off certain parts of a cell's DNA code or blueprint in healthy breast tissue cells, may also play a critical role in the development of breast cancer.

Mice lack colonic BMI - 1 stem cells that play a critical role in how colon cancer forms — or carcinogenesis — and how material passes through the cell lining of the intestinal wall — or gut permeability.

The immune system plays a critical role not only in fending off pathogen attack, but also in cancer surveillance, and more recently as a tool in immunotherapy - based treatments.

«Breast cancer gene could play critical role in obesity, diabetes.»

The ERK pathway plays a critical role in embryonic development and tissue repair because it instructs cells to multiply and start dividing, but when over activated cancer growth occurs.

Lee and Cate's research hints that this secret lever, which triggers translation of only a special subset of mRNAs — perhaps only 500 out of some 10,000 mRNAs produced by a cell — will be found to play a critical role in other diseases besides cancer, as well as in plants and animals.

«The work from Lynne Maquat's lab is critical because it demonstrates the role for NMD in cancer cell survival and shows us how the NDM pathway might be connected to chemotherapy response,» said Hartmut «Hucky» Land, Ph.D., director of research at the Wilmot Cancer Instcancer cell survival and shows us how the NDM pathway might be connected to chemotherapy response,» said Hartmut «Hucky» Land, Ph.D., director of research at the Wilmot Cancer InstCancer Institute.

Published in the May 1 edition of Cancer Research, the study supports a critical role for IGF - 1R signaling in prostate - tumor development and identifies an important IGF - 1R - dependent growth control mechanism, according to the authors.

Our PDX models and other next - generation cancer modeling platforms allow you to address critical questions in oncology research, such as unexplained drug resistance, drug efficacy, genomic heterogeneity in solid tumor, and the role of the immune system in drug response.

The critical roles of tumor - initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis using a unique humanized orthotopic mouse model.

It has a critical role in regulating cell proliferation, so understanding ERK regulation is central to efforts to design new cancer drugs and other disease therapies.

HIF - 1 plays important roles in critical aspects of cancer biology, including tumor angiogenesis, regulation of glucose and energy metabolism, invasion, and metastasis.

Cutaneous SCC is a clinically aggressive cancer, and the inactivation of p21waf1 / cip1 has been shown to play a critical role in the formation of skin tumor in knockout mice models (14, 15).

«Nutrient scavenging by autophagy is a process that tumors hijack to meet their energetic requirements and to provide the necessary cellular building blocks for growth in a stressed tumor micro-environment» said White, «Preclinical models have demonstrated a critical role for autophagy in multiple cancer types.»

The answers they have discovered so far reveal critical information about gene regulation; specifically, that cells are used to record the positional identity in human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in cancer progression, especially in metastasis, whereby cancer cells spread to other parts of the body.

He is the former vice president and chief operating officer of Sanford Research and played a critical role in establishing the Edith Sanford Breast Cancer Research program and Sanford Health BioBank.

Here, we uncovered a critical role for ABL kinases in the regulation of breast cancer metastasis to bone.

For example, a research team last year used LINCS data to identify the role of a critical transcription regulator, heat shock factor 1 (HSF1), in cancer.

In humans, the twenty - five known selenoproteins play critical roles in anti-oxidant defense, thyroid hormone metabolism, development, muscular and nervous system function, inflammation, and canceIn humans, the twenty - five known selenoproteins play critical roles in anti-oxidant defense, thyroid hormone metabolism, development, muscular and nervous system function, inflammation, and cancein anti-oxidant defense, thyroid hormone metabolism, development, muscular and nervous system function, inflammation, and cancer.

The CXCR4 receptor and its ligand CXCL12 (also named stromal cell - derived factor 1, SDF1) have a critical role in chemotaxis and homing, key steps in cancer metastasis.

«It is believed that environmental and lifestyle factors, such as diet, play a critical role in increasing human breast cancer risk, and so we use animal models to reveal the biological mechanisms responsible for the increase in risk in women and their female progeny,» says Hilakivi - Clarke.

The high folate content of beetroot plays a critical role in skin health by stimulating the production and repair of cells, and research has indicated the potential of folate in protecting sun exposed skin against skin cancer.

Glutathione, which Mark Hyman, M.D., calls one of the most powerful of all antioxidants, may play a critical role in preventing cancer and infections.

As the studies summarized above suggest, the mechanism of cancer cell death caused by selenium is its ability to increase extracellular glutathione, an antioxidant that plays a role so critical in eliminating toxins from the body, that Dr. Mark Hymann has called it «the mother of all antioxidants».

Moreover, the correct nutritional management of dogs with cancer can also enhance the function of the immune system, which plays a critical role in modulating and controlling cancer growth, as well as the tolerance of and response to cancer therapy.

www.komen.org — «Since 1982, Komen has played a critical role in every major advance in the fight against breast cancer, transforming how the world talks about and treats this disease and helping to turn millions of breast cancer patients into breast cancer survivors.»

«These past few days have demonstrated that people are committed to fighting breast cancer and they recognize Planned Parenthood plays a critical role in that fight,» said Dianne Luby, President / CEO of PPLM.