Not exact matches
A team led
by principal investigator Donald M. O'Rourke, MD, an associate professor of Neurosurgery at Penn, and Marcela Maus, MD, PhD, showed that CART - EGFRvIII
cells had an acceptable safety profile,
crossed the blood - brain barrier, infiltrated the tumor, and prompted an
immune response, resulting in reduction of the EGFRvIII tumor antigen in GBM
cells.
However, the exact cytoskeletal strategy that the
cell uses to
cross the physical BM barrier depends on the physiological context and the physical environment, as observed
by examining actin structures in invading cancer and
immune cells, and in
cells that invade during developmental processes such as angiogenesis and anchor
cell invasion in Caenorhabditis elegans.
With bitters, digestive enzyme secretions are increased, helping to promote the complete breakdown of nutrients into their absorbable units, preventing gas formation when large molecules are acted upon
by bacteria further down the small intestine.2, 11 The complete breakdown of proteins is particularly important, as the
cross reactivity of
immune cells between undigested protein molecules and intestinal
cells plays an important role in the etiology of conditions such as celiac disease.15 Insulin and glucagon secretions are stimulated, helping to stabilize blood sugar levels.3, 11 Many bitters formulations have been traditionally used in the treatment of type 2 diabetes, and it is interesting to point out that many naturally sweet substances are often paired with some bitterness in nature.4, 11 Herbalist Jim McDonald hypothesizes that our cravings for sweetness may mask cravings for bitterness for this reason.4