Crane continued this work after graduate school in a fellowship at California Institute of Technology, where he combined his background in
crystallography with spectroscopic methods and also learned how to use photochemical techniques to initiate electron transfer reactions.
Then he combined
crystallography with small angle X-ray scattering to visualize the entire enzyme and observe how ATP powers its strand passage reaction.
To do this work, Crane is integrating X-ray
crystallography with electron microscopy and pulsed dipolar electron spin resonance spectroscopy.
In this work, she combines
crystallography with techniques from biochemistry and spectroscopy to understand these enzymes.
Henry Chapman, who worked at Lawrence Livermore National Laboratory (LLNL) from 1996 to 2007, will be presented on Jan. 26 with an honorary doctorate by Sweden's Uppsala University for his work on developing techniques for imaging and
crystallography with intense X-ray pulses.
Henry Chapman, who worked at Lawrence Livermore National Laboratory from 1996 to 2007, will be presented with an honorary doctorate by Uppsala University for his work on developing techniques for imaging and
crystallography with intense X-ray pulses.
Hodgkin went to Somerville College Oxford to study chemistry, then to Cambridge in 1932 for a Ph.D. in
crystallography with J. D. («Sage») Bernal, on Uncle Joseph's advice.
Ultrafast electron
crystallography with the use of a tilted optical geometry technique afforded the necessary atomic - scale spatial and temporal resolutions.
Not exact matches
The technique, called
crystallography, was a bit like making a shadow animal on the wall
with one's hand and a flashlight.
After graduating in 1990, Ban went to the United States to do his Ph.D. at UC Riverside
with crystallography expert Alexander McPherson.
We report direct determination of the structures and dynamics of interfacial water on a hydrophilic surface
with atomic - scale resolution using ultrafast electron
crystallography.
In particular, ELETTRA, a third generation synchrotron radiation facility dedicated to many aspects of materials science such as
crystallography, spectroscopy, and lithography, has put me in touch
with a very broad scientific community and allowed me to find opportunities.
For those of you who aren't familiar
with x-ray
crystallography, I'll describe this horror show of a research field, which produces fascinating and useful data via tedium and — yes — blind luck.
The new 3 - D structure, which was obtained using X-ray
crystallography and electron microscopy, revealed that the outer surface of the Zika NS1 protein has substantially different electrical - charge properties than those of other flaviviruses — indicating it may interact differently
with the members of an infected person's immune system.
There was more room for them in new, expanding sciences such as x-ray
crystallography, particularly
with the tiresome work required before the advent of the electronic computer and automatic methods.
These three institutes have long collaborated; in 2002, they teamed up
with the nearby Institute for Structural Biology (IBS), which contributed its complementary expertise in
crystallography, nuclear magnetic resonance, and electron and mass spectrometry to form the Partnership for Structural Biology (PSB).
The prize will be equally split between biophysicist Venkatraman Ramakrishnan of the MRC Laboratory of Molecular Biology in Cambridge in England, biochemist Thomas Steitz of Yale University and molecular biologist Ada Yonath of the Weizmann Institute of Science in Rehovot, Israel, for their work in using x-ray
crystallography to get a precise, atomic - scale map of the ribosome — the protein - making machine in all cells
with nuclei that makes life possible.
Think of combining
crystallography and chemical analyses to the study of DNA, which led to the discovery of the double helix, or even of bringing the American blues tradition to young art students in the British port of Liverpool, who combined it
with their native approach to harmonies and created the Beatles.
This marks the second time in four years that the chemistry Nobel has been awarded to someone working
with x-ray
crystallography; in 2006 Roger Kornberg took the prize for detailing the structure of messenger RNA, which is the molecule that carries the information the ribosome uses to build proteins, such as insulin or hemoglobin.
Yonath is just the fourth woman ever to win the Nobel Prize for Chemistry and the first since 1964 when Dorothy Hodgkin won for her x-ray
crystallography work
with penicillin and cholesterol.
The key to that is x-ray
crystallography in which x-rays are shone through a crystal filled
with ribosomes, creating a scatter pattern that reveals their inner workings (detected by CCDs, the inventors of which were honored yesterday
with the 2009 Nobel in Physics).
We used mutations
with natural and unnatural amino acids, electrophysiological recordings, and x-ray
crystallography to identify a charge transfer center in voltage sensors that facilitates this movement.
Gordon supervises a lab of some 20 graduate students and postdocs
with expertise in disciplines ranging from ecology to
crystallography.
X-ray
crystallography, a technique that can produce images of molecules
with exquisite detail, has one drawback: It works best on crystals, in which many copies of a molecule are lined up in a regular array.
Arrangements
with the then head of the school of
crystallography, Julia Goodfellow, were swiftly sorted out, and since October 2001 I reside at Birkbeck for 2 days per week (working from home the rest of the time).
«One of the most important results of this work is that the structure obtained at LCLS is almost identical to the structure obtained
with traditional
crystallography, despite the fact that the LCLS data were collected from crystals 100 times smaller by volume and at room temperature,» Cherezov stressed.
Complexes
with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray
crystallography showed that the antibody bound to a conserved epitope in the F subdomain.
Celebrating
crystallography's centennial; how climate pushes malaria uphill; roundup of daily news
with David Grimm.
Yes, we've all heard of Marie Curie's exploits
with radioactivity (1890) and Rosalind Franklin's indispensable x-ray
crystallography work toward the discovery of the DNA double - helix (1953), but how many of us know that Nettie Maria Stevens (1905) demonstrated that the X and Y chromosomes were responsible for determining the sex of an individual?
«We synthesized a new compound, demonstrated its effectiveness
with biological data, and learned more about its interactions
with proteins through X-ray
crystallography and computational analysis,» says UConn associate professor of chemistry José Gascón, a specialist in quantum and molecular mechanics.
I had completed a postdoc
with Prof. Michael Rossmann during which I studied virus - receptor relationships by using x-ray
crystallography and electron microscopy.
For this latest study, Yaghi and Osamu Terasaki, a chemist
with Stockholm University, along
with collaborators from institutes in the United States, China, South Korea and Saudi Arabia, interfaced a gas adsorption apparatus
with a form of X-ray
crystallography, called in - situ small angle X-ray scattering (SAXS).
Thatcher could support the reforms, Agar argues, because she «had lived the life of the working research scientist, as a final - year chemistry student in Dorothy Hodgkin's x-ray
crystallography laboratory, as an investigator of glues for BX [plastics company] and as a food chemist for Lyons & Co.... [I] t was precisely because Thatcher knew what scientific research was like that made her impervious to claims that science was a special case,
with special features and incapable of being understood by outsiders, and therefore that science policy should be left in the hands of scientists.
LiWang's lab also collaborates
with X-ray crystallographers like Carrie Partch at the University of California, Santa Cruz, because X-ray
crystallography is a powerful technique to capture static structures of proteins and their complexes at atomic and near - atomic resolution.
To develop better drugs, scientists want to use a process called x-ray
crystallography to develop a complete picture of how integrase inhibitors — the class of HIV drugs that target integrase — interact
with the virus.
An international collaboration of scientists led by Omar Yaghi, a chemist
with the Lawrence Berkeley National Laboratory (Berkeley Lab), has developed a technique they dubbed «gas adsorption
crystallography» that provides a new way to study the process by which metal - organic frameworks (MOFs)-- 3D crystals
with extraordinarily large internal surface areas — are able to store immense volumes of gases such a carbon dioxide, hydrogen and methane.
In collaboration
with Dr Raphael Gasper - Schönenbrücher from the work group Protein
Crystallography, headed by Prof Dr Eckhard Hofmann, they solved the atomic structure of GtCPES.
The TSRI laboratories of Professor Erica Ollmann Saphire and Assistant Professor Andrew Ward are studying the structures of these antibodies using techniques called electron microscopy, which creates high - resolution images by hitting samples
with electrons, and X-ray
crystallography, which determines the atomic structure of crystalline arrays of proteins.
Using X-ray
crystallography, carried out in collaboration
with the lab of Christoph Müller, the team was able to determine for the first time the structure of Oskar's two domains, called OSK and LOTUS.
The tiny cocoons were by far the smallest protein crystals ever imaged
with X-ray
crystallography, and the results point the way to using even smaller crystals — or even uncrystallized proteins and other biomolecules — for structure analysis.
A team of researchers led by the Department of Energy's Oak Ridge National Laboratory used neutron macromolecular
crystallography to investigate the different states of three glaucoma drugs as they interact
with the targeted enzyme, human carbonic anhydrase II (hCA II).
Time - lapse
crystallography was used by National Institute of Environmental Health Sciences (NIEHS) researchers to determine that DNA polymerase, the enzyme responsible for assembling the nucleotides or building blocks of DNA, incorporates nucleotides
with a specific kind of damage into the DNA strand.
That work triggered a close race between the Cambridge University group and a rival team at MIT in deciphering tRNA's 3D structure at atomic resolution
with x-ray
crystallography,
with the two labs publishing results within 2 weeks of each other.
Electron cryo - microscopy is emerging as a complementary approach in cancer drug design to X-ray
crystallography — which involves generating highly ordered crystals of proteins and hitting them
with X-ray radiation.
In Wilson's laboratory, postdoctoral fellow Rui Xu, the study's first author, along
with Staff Scientist Xueyong Zhu and Research Assistant Wenli Yu, performed X-ray
crystallography studies of the Sh2 HA protein bound to several avian - and human - type receptors.
But BRCA2 is a large, fussy molecule, difficult to isolate and characterize
with x-ray
crystallography.
To find the structure, the MIT team used X-ray
crystallography, which they performed in a special chamber
with no oxygen.
Access to instruments for neutron
crystallography on the high flux neutron source of the ILL In collaboration
with the ILL, access is provided to two instruments for neutron
crystallography.
Conventional techniques used to image proteins, such as X-ray
crystallography and nuclear magnetic resonance imaging, don't work
with fibrous structures such as amyloids.
With cutting - edge
crystallography and microscopy techniques, Christopher Barnes aims to reveal — in extreme detail — how newly isolated antibodies neutralize HIV - 1 by latching onto viral envelope proteins.