They then performed serial behavioral tests on the mice, including Y - maze test (to assess working memory), rotarod test (motor function and learning), and contextual and
cued fear condition test (fear learning and memory).
The read - out that is measured in contextual and
cued fear conditioning is a freezing response that occurs following the pairing of an unconditioned stimulus (US), such as a foot shock, with a conditioned stimulus (CS), such as a particular context or cue (tone)[15 — 17].
In the fear conditioning paradigm, only the combination of J147 and donepezil rescued the hippocampal - dependent deficit in contextual and
cued fear conditioning, suggesting the compounds» synergistic effect for this particular type of memory (Figure 4C, D).
The readout that is measured in contextual and
cued fear conditioning is a freezing response that occurs following the pairing of an unconditioned stimulus such as a foot shock, with a conditioned stimulus such as a particular context or cue (tone).
Not exact matches
The new paper «Extinction Reverses Olfactory
Fear Conditioned Increases in Neuron Number and Glomerular Size» highlights the results of a first of its kind study in which researchers reveal that the olfactory system in the brain is biologically and structurally more sensitive to trauma cues than previously thought, and that it's possible for fear behaviors associated with emotional learning to be reversed through exposure - based talk ther
Fear Conditioned Increases in Neuron Number and Glomerular Size» highlights the results of a first of its kind study in which researchers reveal that the olfactory system in the brain is biologically and structurally more sensitive to trauma
cues than previously thought, and that it's possible for
fear behaviors associated with emotional learning to be reversed through exposure - based talk ther
fear behaviors associated with emotional learning to be reversed through exposure - based talk therapy.
Following contextual
fear conditioning, we then tested
fear memory retrieval in response to an auditory
cue, within a different environment.
The following day (48 hs after auditory
conditioning),
cued fear responses were examined in a different arena (c, f).
The hippocampus and the amygdala are required for
fear memory where the hippocampus is involved in the formation and retrieval of context
fear associations and the amygdala is involved in
conditioning and recall of associations to contextual and discrete
cues [18, 19].
The mice that received the chemical also better remembered
cues associated with unpleasant stimuli — the sort of
fear conditioning that could help a mouse avoid being preyed upon.
Furthermore, when the dogs were worked by the individual who originally trained them, their stress and
fear - related behaviours was further increased, showing that the presence of the handler and the sound of his commands had become
conditioned cues associated with previous shock.
Fear conditioning shapes attention orienting to social threat
cues