Sentences with phrase «cued fear memory»
Huynh, T.N., Santini, E., and Klann, E. (2014) Requirment of mammaliant target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.
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Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now for the first time identified a sub-region in the brain that works to form a particular kind of memory: fear - associated with a specific environmental cue or «contextual fear memory.»
They then performed serial behavioral tests on the mice, including Y - maze test (to assess working memory), rotarod test (motor function and learning), and contextual and cued fear condition test (fear learning and memory).
Following contextual fear conditioning, we then tested fear memory retrieval in response to an auditory cue, within a different environment.
The hippocampus and the amygdala are required for fear memory where the hippocampus is involved in the formation and retrieval of context fear associations and the amygdala is involved in conditioning and recall of associations to contextual and discrete cues [18, 19].
In the fear conditioning paradigm, only the combination of J147 and donepezil rescued the hippocampal - dependent deficit in contextual and cued fear conditioning, suggesting the compounds» synergistic effect for this particular type of memory (Figure 4C, D).