Using high throughput robotic platforms and 3D multicellular tumor spheroid cell
culture models for high throughput RNAI and drug screens for target identification and validation
«The model will help scientists identify new approaches to design and establish cell
culture models for other human cells that previously had resisted viable culture conditions,» said Ozdener
Developing a three dimensional in vitro cell
culture model for studying breast and prostate cancer using starPEG - heparin hydrogels.
A549 lung epithelial cells grown as three - dimensional aggregates: alternative tissue
culture model for Pseudomonas aeruginosa pathogenesis.
Positive data for blood brain barrier (BBB) penetration (High) were also obtained for J147 using the MDCK - MDRI cell
culture model for assaying the BBB penetration potential of drugs.
Not exact matches
It's a hybrid business
model that demands a unique corporate
culture, a modern organizational structure, an appetite
for risk and, most important, a talented and flexible team.
Instead, make it a story about the
culture of innovation and the many people who have sustained it; giving others role
models and the license to have something to strive
for.
With one recently - auctioned 14 - bedroom, two - pool mansion on Park Lane Circle being
modelled on the Palace of Versailles, it's clear that the residents of Bridle Path have a
cultured eye
for the world's best things.
Similarly, having led my own companies through fairly major changes - combined with thorough research — I have developed a
model for culture driven transformation (CDT).
It's true that leaders are essential role
models for a company's
culture, but real success comes when you also empower employees to take ownership.
Zappos has long been a role
model for corporate
culture.
My role is to continue to be a cheerleader
for our
culture and business
model.
In a time when many companies struggle with employee retention, his family business
model has supported a
culture where many employees have stayed
for more than 20 years and refer their family members
for employment.
Leadership should define their desired
culture, making clear what behaviors, values, and beliefs they want to see and
model them
for the organization.
To build a team that is reflective of the time, you have to maybe look outside traditional
models... Oftentimes we're looking
for, obviously people with experience, but also people that are creative and passionate about
culture.
We set the standard
for servant leadership and
model the behaviors and practices that need to take place
for culture change.
Not only is there a different skill set between search
for a business
model (or in my case collaborative literacy program
model) and executing that
model, there's a different skillset in documenting, training, and codifying the
culture and practices of that
model.
Kelly suggests leaders must «
model the
culture: spending time with employees, treating people with respect, having fun, being there
for them personally and professionally, and putting people first — with empathy, kindness and compassion.»
Join us
for a session and discover how happiness and the DH
model can help bring your ideal
culture to life.
Religion, and Christian communities in particular, can and should, says the author,
model the civic
culture for which he hopes - a
culture that will retrieve and rehabilitate the best of the liberal Enlightenment tradition.
That paideia became the
model for excellence in theological schooling was simply inherent in the way the Christian thing was construed by Christians and pagans alike in a Hellenistic
culture that understood itself to be paideia
In this task the Japanese philosopher Nishida Kitaro serves as a
model for some of us (
for the reason that I have already given) since, in reflecting on Japanese
culture, he turned to Western conceptualities to enable a dialogue between the two to take place.
Whenever pluralism becomes too content with a relaxed
model of «dialogue,» it can ignore the need
for conflict and the actualities of systematic distortions in the personal (psychosis), historical (alienation and oppression) and religious (sin) dimensions of every person,
culture and tradition.
The communion of saints is not only a theological concept, it is the
model for a vibrant Catholic literary
culture.
If the Eastern Orthodox
culture of the Far East was nearly destroyed by communism and Islam, and Catholic and Protestant Europe were nearly destroyed by secularism, then what
model exists
for us to follow?
Here we see what it is to
model a new humanity; and there is enough to suggest that such
modeling can be contagious, can open up new possibilities
for a whole
culture.
This article is arguably hypocritical as well as stomach - churning, since it begins with the suggestion that «Because of the amazingly diverse multicultural contexts in which pastoral ministers are called upon to work today, it is impossible to prescribe one liturgical
model that will be always and everywhere appropriate»: this flexible and open - minded liturgist then proceeded to argue in The Tablet that only the Mass of Paul VI is always and everywhere appropriate and that its very existence automatically abrogated all previous liturgies
for ever: presumably those who prefer the older form are not to be given the dignity of a group or «
culture» to be catered
for by his free and easy multicultural ways, but are to be simply dismissed as a bunch of liturgical perverts.
According to the biblical
model of the person, which has prevailed
for many centuries and is still largely normative
for Western
culture, a person consists of a physical organism, including a brain of unique proportions and capabilities.
There will be more, faster and more aggressive cultural neo-colonialism: developing countries can get ready
for a cultural tsunami imposing on their governments and
cultures the western «gender equality»
model and all it hides and contains.
Indeed, there are suspicions in some quarters that the process
model itself may be inimical to the ideas of conversion, transformation, and revolution, and it is perhaps this thought that underlies George Pixley's dark hint that Whitehead's philosophy of
culture is «open to appropriation
for counter-revolutionary purposes.
This tentative
model for understanding the causes of problem drinking is offered in the report of the Cooperative Commission on the Study of Alcoholism: «An individual who (1) responds to beverage alcohol in a certain way, perhaps physiologically determined, by experiencing intense relief and relaxation, and who (2) has certain personality characteristics, such as difficulty in dealing with and overcoming depression, frustration, and anxiety, and who (3) is a member of a
culture in which there is both pressure to drink and culturally induced guilt and confusion regarding what kinds of drinking behavior are appropriate, is more likely to develop trouble than will most other people.»
But our
culture longs
for models of human excellence that extend far beyond mere technical competence and that temper the pride of intellect with wisdom and charity.
The growing difference within evangelicalism regarding contextualization is described helpfully by David Wells in his essay: «In the one understanding of contextualization, the revelatory trajectory moves only from authoritative Word into contemporary
culture; in the other, the trajectory moves both from text to context and from context to text...» Increasingly, evangelicals are opting
for the second of these
models - an «interactionist» approach, to use William Dymess» terminology.
If our mistaken notion leads us to an impassive, self - sufficient God in heaven, then the
model for humanity,
for Western
culture,
for ourselves, is that we should also be self - sufficient, impassive, beyond need, not to be imposed on.
(ENTIRE BOOK)
For Kelsey, «Athens» (based on the Greek paideia, «
culturing,» «character formation,») and «Berlin» (based on the German Wissenschaft, «orderly,» «disciplined critical research,» «professional») represent two very different — and ultimately irreconcilable —
models of excellent education.
Looking primarily to
models based on quantitative research methodologies to provide a clear direction
for policy in regulating media and violence can also distract policy makers from coming to grips with other difficult but more important value questions that impinge on the issue of media and violence, such as the purpose of broadcasting, issues of ownership and control of media, the international context of Australian media, the dominant economic nature of most of Australia's social communications, the distinctive ways in which the media reproduce and reconstruct myths and symbols of violence from within the
culture, and how audiences use and respond to media myths and symbols.
The «Christ transforming
culture»
model, which does allow
for both affirmation and dissent, assumes that the real arena of God's action is in the surrounding
culture, not in and through the church.
Ten years of travelling the world as a
model gave Sarah a deep appreciation
for new
cultures.
Time
for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of
for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous
for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order
for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as
for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal
for a club of this size and financial might... the fact that we could find money
for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business
model needs a complete overhaul...
for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant
culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business
model was that of a «selling» club... does it really make sense that we could only make a cheeky bid
for Suarez, or that we couldn't get Higuain over the line when he was being offered up
for half the price he eventually went to Juve
for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke
model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness
for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...
The problem is that his business
model of top four is good enough seems to have generated a
culture at the club which stops it even challenging
for winning the PL come the latter part of the season.
The South American nations are renowned
for developing tough but
cultured central defenders, and Victor Cabrera looks to be the latest
model off the production line.
Volume XIV, Number 2 The Social Mission of Waldorf School Communities — Christopher Schaefer Identity and Governance — Jon McAlice Changing Old Habits: Exploring New
Models for Professional Development — Thomas Patteson and Laura Birdsall Developing Coherence: Meditative Practice in Waldorf School College of Teacher — Kevin Avison Teachers» Self - Development as a Mirror of Children's Incarnation: Part II — Renate Long - Breipohl Social - Emotional Education and Waldorf Education — David S. Mitchell Television in, and the World's of, Today's Children — Richard House Russia's History,
Culture, and the Thrust Toward High - Stakes Testing: Reflections on a Recent Visit — David S. Mitchell Da Valdorvuskii!
Girls are also sent conflicting messages by our
culture and by their peers: that it is acceptable
for them to participate in sports, but they also need to maintain the figure of a super
model.
This is difficult in a stressed out
culture and parents that are themselves obviously very stressed out, but it's an extremely important thing to
model for your child the skills of managing your own life successfully.
«Although well intentioned, the last Government received very little
for their money in terms of social mobility and a reduction in the gap between the rich and the poor, and they have further fuelled a
culture of benefit dependency in which children grow up seeing parents and grandparents who have never worked as their role
models, in which people are better off living apart than living together, and in which there is no incentive to work because of the fear of becoming worse off.
This study identifies myomerger as a fundmentally required protein
for muscle development using cell
culture and laboratory mouse
models.
With our human gut - on - a-chip, we can not only
culture the normal gut microbiome
for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as
model specific diseases to understand complex pathophysiological responses of the intestinal tract.»
The social stigma of entering a male - dominated field with a macho
culture, the fear of intimidation and discrimination, and the lack of mentors and role
models in positions of power are commonly cited reasons
for women exiting or failing to enter the engineering workforce.
Neuroethicist Wrye Sententia, acting director and cofounder of the nonprofit Center
for Cognitive Liberty and Ethics (CCLE), responds that fears of a new drug
culture à la the «tune in, turn on, drop out» 1960s just do not apply to the modern better - living - through - chemistry
model.
The journal's home page explains that translational medicine «builds on basic research advances — studies of biological processes using cell
cultures,
for example, or animal
models — and uses them to develop new therapies or medical procedures.»