Sentences with phrase «cultured cells engineered»
The team first tested the antibody in cultured cells engineered to express the Nav1.7 sodium channel.
https://www.sciencedaily.com/ Not exact matches
One of the 12 audience members was Ben Chao, a chemical engineer with a Ph.D. — not at all qualified to make a judgment on Scott's abilities in the area of «Approaches to Developing Serum - Free Media Formulations for Mammalian Cells in Culture.»
The cells used to build the organs could be cultured from stem cells taken from fat or bone - marrow tissue, he says: «We could engineer a blood vessel from your own cells.»
The new research, which studied the immortalization process using genome - engineered cells in culture and also tracked skin cells as they progressed from a mole into a malignant melanoma, suggests that telomerase plays a more complex role in cancer.
An APC - mimetic scaffold that was engineered to activate a specific type of CAR - T cell was able to generate higher numbers of the modified T cells over longer periods of culture than analogously designed expansion beads, and the resulting cells were similarly effective in killing the lymphoma cells in the mice.
They found that indeed, they do, and that stimulating these cells led them to kill cells infected with HIV - 1 derived from latently infected cells, both in culture and in mice engineered to have a human immune system.
Existing cell culture models were not very realistic, Tuveson says, and creating genetically engineered mice took up to a year, compared with up to 3 weeks for pancreatic cancer organoids.
Researchers in China have engineered bendable batteries that can run on body - inspired liquids such as normal IV saline solution and cell - culture medium.
The next task will be to engineer neurons in cell cultures so that they manifest one or more of the variants.
When the researchers used gene engineering techniques to knock out DDX3 expression in laboratory - grown cell cultures that highly expressed this protein, cell proliferation was half that of cell cultures with high DDX3 expression.
The researchers, led by University of California, San Diego neuroscientist Mark Tuszynski, took skin cells from the patients, grew them up in a culture dish and genetically engineered them to make human nerve growth factor (NGF).
«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.
Incorporating advances in engineering, cell culture, genetics, and biomechanics, the «living» robot brings Parker's dream of a humanmade human heart a step closer.
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.
Wanting to pursue more experimental research, he headed to the Massachusetts Institute of Technology for a postdoc to join a lab of engineers who focused on cell and tissue culture experiments.
Brown University engineers have demonstrated a technique for making 3 - D - printed biomaterials that can degrade on demand, which can be useful in making intricately patterned microfluidic devices or in making cell cultures than can change dynamically during experiments.
After outfitting the nanoparticles with their molecular assistants and engineering the cell membranes to receive the nanoparticles, the team applied a solution of nanoparticles to the cell cultures and switched on a magnetic field.
To find out, he engineered cells in culture to contain either the heat - or cold - sensitive TRP receptors, which when triggered change the biochemistry of the cell in a measurable way.
Mark Talary, a postdoc in the Institute of Molecular and Biomolecular Electronics at the University of Wales Bangor describes the institute as «an engineering department with cell culture facilities,» and says, «you need to have experience outside your core discipline.»
The engineered cell culture enabled interaction between three cell types of the airways and reproduced their physiological interfaces — becoming essentially an «organ - on - chip.»
The means to enhance the production of cartilage - specific extracellular matrix is needed for cell - based tissue engineering applications, since cultured chondrocytes quickly lose their cartilage - specific phenotype.
Most modern biologics are assembled inside vats — or bioreactors — that house genetically engineered microbes or mammalian cell cultures.
Tissue engineering of bone grafts — Cell versus tissue culturing.
This kit utilizes the DEF ‑ CS culture system, recognized for its suitability for genome engineering (Valton et al. 2014) and single - cell cloning (Feng et al. 2014), to promote reliable growth of hiPS cells in a feeder - free and defined environment.
Katja Schurig (Storch, TUD)-- «Tissue engineering for reconstructing the central dopaminergic nigro - striatal pathway in Parkinson's disease: Cutting edge cell culture studies» (2012)
* Contains practical, hands - on information for tissue engineers and students * Provides comprehensive protocols covering numerous topics, including polymer synthesis, cell culture, encapsulation, bioreactors, therapeutics, and the creation of tissues and organs * Includes contributions by leaders in the latest areas of research, such as stem cells and fetal tissue engineering
This must be accomplished by using a process known as germ - line transmission, where the primordial germ cells (PGCs) of an early embryo are edited, grown in cultures, and then reproductively transmitted through surrogate host parents to generate live, engineered birds.
Reduced contraction of skin equivalent engineered using cell sheets cultured in 3D matrices.
Our team would like to be able to research passenger pigeon genes for de-extinction while primordial germ cell cultures are developed, and an Australian team has developed an effective way of bypassing cell cultures for engineering birds by going directly to the primordial germ cells in the embryo.
Tissue engineering is bringing together advances from stem cell biology, microfluidics, robotics, and 3 - D cell culture to develop novel products...
To do de-extinction successfully we need the power to engineer large sections of DNA sequentially in a period of weeks / months rather than years, so primordial germ cells cell cultures will be the mainstay of our effort, but while we wait we could establish a stock of birds that have a few passenger pigeon mutations as a foundation.
The Chips are cultured under continuous flow within engineered 3D microenvironments that go beyond conventional 3D in vitro models by recapitulating in vivo intercellular interactions, spatiotemporal gradients, vascular perfusion, and mechanical forces — all key drivers of cell architecture, differentiated function, and gene expression.
While the genome editing capabilities without cultured primordial germ - cells is limited and a slower process, the optimization of methods for handling embryos and caring for engineered birds will be instrumental to an efficient de-extinction program as well as genetic rescue of other birds with similar parenting behaviors to pigeons.
The «heart - on - a-chip,» which builds off previous successful iCHIP research on the peripheral and central nervous systems, involves the use of human cardiac cells cultured for up to nine days on the engineered chip.
Dr. Hackam's team has developed techniques of intestinal stem cell isolation and culture, and are working with tissue engineers and chemists towards the development of an artificial intestine, which has been tested in large and small pre-clinical models.
The Boyce Thompson Institute (BTI) Center for Plant Biotechnology Research was established to support projects at BTI that utilize genetic engineering and plant cell culture.
The ideal method to engineer bird genomes is germ - line transmission via cultured primordial germ cells.
«Thus it seems that outside of [genetically engineered mice or a cell culture dish or other animal models] that the search for the true role of the growth potential for IGF - 1 in adult muscle hypertrophy is a vain one.»
«Looking further out, Finless is concentrating its R&D efforts on tissue engineering that will allow them to culture not just disconnected cells but «solid chunks of things that are a facsimile of fish flesh» — basically fish fillets.»
Tomas Zaragoza1754 Woodridge LaneMemphis, TN 38115 (222-445-7252) [email protected] Job Objective: To be able to work as a Pharmaceutical Engineer in a research oriented organization where my skills in purification process, cell culture, and -LSB-...] Continue Reading →
Tags for this Online Resume: biomaterials, biopolymers, cell culture, stem cells, rheology, materials science, scientist, associate scientist, biomedical engineer, hydrogels, polymers
Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign