The enzyme, called tankyrase, may prove useful for extending the lives of
cultured cells grown to repair burned skin and other damaged tissue.
Not exact matches
The trial was actually supposed to launch back in August but was delayed because
growing and
culturing the genomically edited
cells took longer than originally expected.
Based on a 3D image such as an MRI scan, Aspect's machine builds relatively complex organic structures out of a «hydrogel» embedded within
cells taken from the body and
grown in a
cell culture.
Bethencourt and Shigeta figured they could use
cell cultures to
grow meat without slaughtering any cows or chickens — but why rely on those animals at all?
Just has reported that it has developed a method to
grow cell cultured chicken without FBS, while Memphis Meats is validating methods to produce its meats without the ingredient.
Hanyu is providing Japanese high school students access to high - tech heated boxes that allow them to
culture animal
cells at home and
grow them into meat - like products.
While some still object to
cells being taken from animals and used by scientists to
grow clean meat in laboratories — and some just don't like the idea of eating a «
cultured» steak created by men and women in white coats — others see the lab -
grown meat revolution as key to solving the environmental crisis linked to meat eating.
Researchers hope the organoids will be better than lab animals or
cells growing in
culture at revealing how the human brain develops, both normally and when things go awry, and identify potential therapeutic or genome - editing targets.
Or did you think that
cell culture would
grow healthy without mommy feeding it regularly?
The most promising chemical — sulforaphane, a naturally occurring compound found in cruciferous vegetables — tamped down glucose production by liver
cells growing in
culture, and shifted liver gene expression away from a diseased state in diabetic rats.
The scientists also showed, in lab -
cultured human
cells, that an ALDH - blocking drug strips regulatory T -
cells of their ability to
grow and protect themselves from cyclophosphamide.
Using human fetal «mini-brains»
grown in 3 - D
cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem
cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).
Permafrost had preserved tissue from one species — a narrow - leafed campion plant — exceptionally well, so researchers at the Russian Academy of Sciences recently decided to
culture the
cells to see if they would
grow.
Dr. Zubair already
grows such
cells in his Mayo Clinic laboratory using a large tissue
culture and several incubators — but only at a snail's pace.
One would
culture thin sheets of meat, seeded by
cells from a living animal, on a reusable polymer scaffold; the other would
grow meat on small edible beads that stretch with changes in temperature.
«It might be possible to
grow these
cells in
culture then bank them so that if or when the mother develops some disease later in life, such as diabetes, her
cells may be defrosted and differentiated into pancreatic beta
cells,» says Lyle Armstrong of Newcastle University, UK, although he too, cautions that more tests are needed to determine exactly what these
cells are.
As it can take weeks to
grow human
cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of
cells cultured within these microfluidic devices over extended times.
As a graduate student at Princeton University, Moshe Pritsker tried in vain to
grow a
culture of embryonic stem
cells from instructions laid out in the methods section of a journal article.
To find out, they put droplets of
culture medium that cancer
cells had
grown in on one side of petri dishes.
The bacterium produced an antibiotic, dubbed lugdunin, which killed a slew of superbugs in
cell cultures and mice with no signs yet of
growing resistance.
The students used a 3 - D printer to design a smaller and more cost - efficient bioreactor — a miniaturized
culture device where neural stems
cells are
grown and eventually become small laboratory brains for research.
The team used human embryonic stem
cells — which can transform into any
cell of the body — and
cultured them in a mixture of chemicals to
grow human brain
cells.
Mackay - Sim's team has solved those problems by developing a method of removing the
cells under a local anaesthetic and
growing them in
culture to produce larger numbers.
The
cells are
grown in the incubator in different concentrations in a
culture medium.
In studies with human fibroblasts that make up connective tissue, Boger's team tested whether NOD1 activity could affect CMV replication in
cultures of
cells grown in the lab.
Writing in the May 4 online issue of the journal Scientific Reports, researchers at University of California, San Diego School of Medicine used a powerful statistical tool called «design of experiments» or DOE to determine the optimal
cell culture formula to
grow and produce hPSCs.
The mistakes arise when fast -
growing «rogue
cells» contaminate
cell cultures and swamp the correct
cells.
This was observed in human ovarian cancer
cells grown in
culture, and then in mouse models of the disease.
It isn't clear exactly why the differences fade, Hochedlinger says, but it may be that the expression of embryonic genes is strengthened as the
cells grow in
culture, gradually overwriting the
cells» old gene - expression patterns.
A human brain
cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis.
The
cells will enable researchers to use lab -
grown cultures to study how the diseases develop.
«Signaling pathways and gene expression profiles are very different in
cells that
grow in 2D and 3D
cultures,» says Oksana Sirenko, a research scientist at Molecular Devices in Sunnyvale, California.
«What made the difference are our unique
cell culture conditions and 3 - D matrix, which allowed
cells to
grow and develop much faster and longer than the 2 - D
culture approaches that are more typically used.»
They are also trying to
culture the undifferentiated
cells for longer before adding Sonic hedgehog, so that they can
grow larger numbers of
cells.
But while researchers have managed to
culture other
cell types, they have failed to
grow the key dopamine
cells needed by Parkinson's sufferers (This Week, 5 August).
Hsiao and colleagues carefully gathered skin samples from donors, and then
grew the skin
cells in
culture before converting them into iPS
cells using the methods created by Yamanaka.
Three types of colon cancer
cells grew faster, producing about 50 to 60 percent more
cells within 24 hours, with the bacteria than they did when
cultured with no bacteria or with a harmless, milk - fermenting bacterium called Lactococcus lactis.
After reactivating the
cells with an electric shock, the group
grew several oocytes in
culture to the blastocyst stage.
With the help of my colleagues I started
growing retroviral vector - containing plasmids in bacterial
cultures, isolating the plasmid DNA and transfecting special producer
cell lines with these plasmids.
Her team decided to try a
cell -
growing approach, called 3D
cultures, that's been successful for other types of
cells that need to form complex structures as they
grow.
Part of the trouble is the ingredients: Subtle variations in tissue -
culture chemicals and Matrigel, or in different stem
cell lines and how they are
grown first in 2 - D
culture, can have a big impact on how the organoids turn out, Novitch says.
Moving forward, he was able to place these taste stem
cells in a
culture dish and prompt them to
grow into the different mature taste
cell types, thus creating a taste bud in a dish — scientifically known as taste organoids.
The scientists transferred the clumps to
cultures where other human ES
cells, marked with green fluorescent protein, were already
growing.
In
cells grown on flat
culture dishes, the expression of thousands of genes didn't match up with their normal patterns, explaining why the
cells from those dishes had been unable to generate new hair follicles.
Results suggest that
cells grown in the device exhibit more natural behaviors than when
grown in traditional
culturing methods, and the filtration by the glomerulus is necessary for healthy
cell function.
So far, VTT has used
cells from its own
culture collection to
grow Arctic bramble
cells, cloudberry
cells and stone bramble
cells in the CellPod.
Microbiologists must wait for
cell cultures to
grow.
A Freiburg - based research group has developed a microfluidic chip where more than one hundred apidose - derived adult stem
cell cultures can
grow and divide.
«Next steps may include efforts to
grow these viruses in
cell culture and functional analyses to assess their risk of being transmitted to primate hosts.»
«In the last few years, it has become possible to order
cultures of human
cells for testing, but they're
grown on a plate, a two - dimensional environment,» says Radisic.