Stage - specific embryonic antigen - 4 is not a marker for chondrogenic and osteogenic potential in
cultured chondrocytes and mesenchymal progenitor cells.
The means to enhance the production of cartilage - specific extracellular matrix is needed for cell - based tissue engineering applications, since
cultured chondrocytes quickly lose their cartilage - specific phenotype.
Special focus is placed on Rho - kinase inhibition, relating to its potential to promote and support extracellular matrix production in
cultured chondrocytes and its role in fibroblast cells as a part of direct chemical cellular differentiation.
For instance, to make a rod with collagen fibers aligned along its length (like a tendon)
they cultured chondrocyte cells in a dog bone - shaped mold with loops on either end.
Not exact matches
«This kind of markers can be useful to monitor responses during
chondrocyte in vitro
culturing, but also be applicable to monitor status of the
chondrocytes during the different kinds of cartilage therapies.
Furthermore, organ
cultured cartilage from ACH mice treated with statin resulted in increased expression of the aforementioned three genes and also in Runx2 and Col10a1, which indicated that statin stimulated both the differentiation and maturation of ACH mouse
chondrocytes.